A5044627186- Multiple Myeloma Research and Treatments
- Prostate Cancer Treatment and Research
- Acute Lymphoblastic Leukemia research
- Cancer Diagnosis and Treatment
- Management of metastatic bone disease
- Acute Myeloid Leukemia Research
- Hematological disorders and diagnostics
- Orthopaedic implants and arthroplasty
- Gut microbiota and health
- HER2/EGFR in Cancer Research
- Cardiac tumors and thrombi
- Childhood Cancer Survivors' Quality of Life
- Clinical Nutrition and Gastroenterology
- Malaria Research and Control
- Chronic Lymphocytic Leukemia Research
- Cancer Mechanisms and Therapy
- Lung Cancer Treatments and Mutations
- Breast Lesions and Carcinomas
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Economic and Financial Impacts of Cancer
- Intensive Care Unit Cognitive Disorders
- Amoebic Infections and Treatments
- Nosocomial Infections in ICU
- Neutropenia and Cancer Infections
- Iron Metabolism and Disorders
Yale Cancer Center
2019-2024
Yale University
2020-2024
University of New Haven
2023
Smilow Cancer Hospital Care Center
2021-2022
Smilow Cancer Hospital
2021-2022
Rutgers, The State University of New Jersey
2014-2021
Rutgers Cancer Institute of New Jersey
2021
Johnson University
2014-2020
Memorial Sloan Kettering Cancer Center
2011-2016
Robert Wood Johnson University Hospital
2015
Graft-versus-host disease (GVHD) is a major adverse effect associated with allogeneic stem cell transplant. Previous studies in mice indicated that administration of the probiotic Lactobacillus rhamnosus GG can reduce incidence GVHD after hematopoietic Here we report results from first randomized enteric regimen trial which allogenic patients were supplemented GG. Gut microbiome analysis confirmed previously reported gut association GVHD. However, clinical was terminated when interim did not...
Abstract Background: Multiple myeloma (MM), the second most common hematologic malignancy in US, has seen improved survival with therapeutic advancements. This presents an opportunity to enhance outcomes through diet and lifestyle. Poor dietary habits obesity are linked adverse MM its precursors—monoclonal gammopathy of undetermined significance (MGUS) smoldering multiple (SMM)—potentially mediated by intestinal dysbiosis which affects immune microenvironment. High Healthy Eating Index (HEI)...
7559 Background: The B cell maturation antigen (BCMA)-targeted antibody drug conjugate belantamab mafodotin enhances cell-mediated antibody-dependent cellular cytotoxicity and phagocytosis. Elotuzumab, a signaling lymphocytic activation molecule family member 7 (SLAMF7) checkpoint inhibitor, activates NK cells induces cytotoxicity. Bela-Elo (NCT05002816) is an ongoing phase Ib/II trial evaluating the safety, tolerability preliminary efficacy of unique combination these two agents in patients...
Metaplastic breast cancer (MBC) is a rare and aggressive subtype of cancer. Tumor characteristics typically feature estrogen receptor, progesterone HER2-negative, triple-negative (TNBC), with poorer prognosis relative to pure invasive ductal or lobular disease. Resistance chemotherapy often leads local recurrence distant metastasis. Genomic profiling has identified multiple molecular abnormalities that may translate targetable therapies in MBC. These tumors are known display higher PD-L1...
Acute lymphoblastic leukemia is commonly cured when diagnosed in the pediatric population. It portends a poorer prognosis if present adult patients. Although adults frequently achieve complete remission, relapse rates are substantial, particularly among elderly and high-risk populations. In absence of prophylactic intrathecal chemotherapy, more than half patients may develop CNS involvement or relapse, which associated with significant risk for systemic illness. This report describes patient...
Case Presentation: An 83-year-old-male presented with subjective fevers, chills, and malaise that began following a trip to India. Vitals were normal exam showed mild expiratory wheezing. Labs significant for wbc 13.8, hgb 11.4, total bilirubin 1.2, alkaline phosphatase 120, ALT 44, AST 60. Chest x-ray left-sided pleural effusion. Abdominal ultrasound hypoechoic mass in the liver. CT scan confirmed mass, noted an irregular-appearing hepatic flexure. He was treated community acquired...
Prostate adenocarcinoma, the most common cancer in males United States, is often diagnosed nonmetastatic setting. The prognosis with metastatic prostate less favorable, though treatment options are typically effective controlling disease for an extended period. Hormonal therapy backbone to management of metastases, decreasing level prostate-specific antigen and reducing patient's cancer-related symptoms. Pulmonary a relatively uncommon initial site involvement, expected respond similar...
Objectives Thrombotic thrombocytopenic purpura (TTP) is a thrombotic microangiopathy that can have high mortality rates without prompt treatment. Standard treatment urgent plasma exchange (PLEX), which leads to disease remission in the vast majority of patients. Deficiency ADAMTS13 (a disintegrin and metalloproteinase with thrombospondin type 1 motif, member 13) alone not sufficient cause clinical manifestations characteristic TTP. We present case acquired TTP, where spontaneous recovery was...
Introduction: There is currently no consensus on management of appendicitis in neutropenic and platelet refractory patients. Case Presentation: A 30 year-old female with high-risk acute monoblastic leukemia 11q23 translocation undergoing Cytarabine Adriamycin induction therapy (day number 18) experienced right lower quadrant abdominal pain. Hospital course had been complicated by persistent fevers despite broad-spectrum antibiotics, transfusion thrombocytopenia. The patient's count was 1 x...
The authors declare no conflict of interest. data used/analyzed in this report are available from the corresponding author on reasonable request without breaching patient confidentiality.
The patient is a 66 year old male with past medical history of diverticulitis and hypertension who presented dysphagia heartburn. Initial CT the chest showed thickened distal esophagus (Fig 1). EGD large fungating mass that was partially obstructing circumferential bleeding in lower third esophagus. This stented. There another medium sized ulcerated no found cardia. Pathology cardiac revealed infiltrating adenocarcinoma histologic grade 2-3. Biopsy 3. Follow up PET scan 2 months after...