A5011682652- Extracellular vesicles in disease
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Metabolism, Diabetes, and Cancer
- Cancer-related molecular mechanisms research
- Light effects on plants
- Circadian rhythm and melatonin
- Cancer, Hypoxia, and Metabolism
- Congenital Diaphragmatic Hernia Studies
- Cancer, Lipids, and Metabolism
- Immune cells in cancer
- Hydrogen's biological and therapeutic effects
- Autophagy in Disease and Therapy
- Free Radicals and Antioxidants
- Pregnancy and preeclampsia studies
- Anesthesia and Neurotoxicity Research
- Advanced Proteomics Techniques and Applications
- Maternal and fetal healthcare
- Advanced biosensing and bioanalysis techniques
- Spaceflight effects on biology
- Nanopore and Nanochannel Transport Studies
- ATP Synthase and ATPases Research
- Mitochondrial Function and Pathology
Hackensack Meridian Health
2021-2024
Hackensack University Medical Center
2024
Center for Discovery
2021-2024
Stellenbosch University
2015-2016
Abstract Cell-to-cell communication is essential for the development and proper function of multicellular systems. We others demonstrated that tunneling nanotubes (TNT) proliferate in several pathological conditions such as HIV, cancer, neurodegenerative diseases. However, nature, function, contribution TNT to cancer pathogenesis are poorly understood. Our analyses demonstrate structures induced between glioblastoma (GBM) cells surrounding non-tumor astrocytes transfer tumor-derived...
Abstract Circulating nucleic acids, encapsulated within small extracellular vesicles (EVs), provide a remote cellular snapshot of biomarkers derived from diseased tissues, however selective isolation is critical. Current laboratory‐based purification techniques rely on the physical properties small‐EVs rather than their inherited fingerprints. We established highly‐selective assay, termed EV‐CATCHER, initially designed for high‐throughput analysis low‐abundance small‐RNA cargos by...
Abstract Lung diseases, including lung cancer, are rising causes of global mortality. Despite novel imaging technologies and the development biomarker assays, detection cancer remains a significant challenge. However, communicates directly with external environment releases aerosolized droplets during normal tidal respiration, which can be collected, stored analzsed as exhaled breath condensate (EBC). A few studies have suggested that EBC contains extracellular vesicles (EVs) whose microRNA...
Mammalian circadian rhythms form an integral physiological system allowing for the synchronisation of all metabolic processes to daily light/dark cycles, thereby optimising their efficacy. Circadian disruptions have been implicated in onset and progression various cancers, including those arising breast. Several links between protein Per2 DNA damage responses exist. Aberrant expression results potent downstream effects on both cell cycle apoptotic targets, suggestive a tumour suppressive...
Aim: The lung is the second most frequent site of metastatic dissemination. Early detection key to improving survival. Given that interfaces with external environment, collection exhaled breath condensate (EBC) provides opportunity obtain biological material including miRNAs originate from lung. Methods: In this proof-of-principal study, we used highly MDA-MB-231 subline 3475 breast cancer cell line (LM-3475) establish an orthotopic tumor-bearing mouse model and investigate non-invasive...
Placenta Accreta Spectrum (PAS) is a life-threatening condition in which placental trophoblastic cells abnormally invade the uterus, often up to uterine serosa and, extreme cases, tissues beyond wall. Currently, there no clinical assay for non-invasive detection of PAS, and only ultrasound MRI can be used its diagnosis. Considering subjectivity visual assessment, PAS necessitates high degree expertise some instances, lead misdiagnosis. In practice, 50% pregnancies with remain undiagnosed...
Abstract Background Current clinical criteria do not discriminate well between women who will or those develop ipsilateral invasive breast cancer (IBC), a DCIS recurrence after ductal carcinoma in situ (DCIS) diagnosis. The 12-gene Oncotype DX® assay (RT qPCR gene-based scoring system) was established and shown to predict the risk of subsequent IBC recurrence. Recent studies have that microRNA (miRNA) expression deregulation can contribute development IBC, but very few evaluated miRNA...