A5078608027- Occupational and environmental lung diseases
- Cancer Immunotherapy and Biomarkers
- Pleural and Pulmonary Diseases
- Lung Cancer Treatments and Mutations
- Lung Cancer Diagnosis and Treatment
- Gastroesophageal reflux and treatments
- Medical Imaging and Pathology Studies
- Eosinophilic Esophagitis
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Esophageal and GI Pathology
- Immune Cell Function and Interaction
- Lung Cancer Research Studies
- Pancreatic and Hepatic Oncology Research
- Cancer Research and Treatments
- Dysphagia Assessment and Management
- TGF-β signaling in diseases
- Tissue Engineering and Regenerative Medicine
- Meningioma and schwannoma management
- Glutathione Transferases and Polymorphisms
- Gastric Cancer Management and Outcomes
- Biomarkers in Disease Mechanisms
- Bone health and treatments
- Immunotherapy and Immune Responses
- Musculoskeletal synovial abnormalities and treatments
- Transplantation: Methods and Outcomes
Medical University of Vienna
2018-2025
Comprehensive Cancer Center Vienna
2020-2025
Universitätszahnklinik Wien
2024
University of Vienna
2022
Sex-based differences in histological subtypes, frequencies of mutations, and response to the various therapeutic approaches lung cancer are well studied. In general, literature is controversial, large majority investigations may not provide evidence from last decade. The objective current study was reveal timely sex-based patients with era immunotherapy molecularly targeted agents. We retrospectively analyzed a consecutive cohort 286 (female:male ratio 134:152/47 %:53 %) who were diagnosed...
Few malignancies provoke as many controversies about treatment pleural mesothelioma. There is limited experience with novel radiotherapy techniques worldwide in adjuvant and particularly neoadjuvant settings within multimodality treatment. The objective of the current study was to investigate long-term outcome intensity-modulated (IMRT) combined macroscopic complete resection or without chemotherapy. We retrospectively analyzed a consecutive cohort 59 patients who were diagnosed mesothelioma...
Abstract Background Pleural mesothelioma (PM) is an aggressive malignancy with poor prognosis . Unlike many other cancers, PM mostly characterized by inactivation of tumor suppressor genes. Its highly malignant nature in absence driving oncogene mutations indicates extrinsic supply stimulating signals cells the microenvironment (TME). Cancer-associated fibroblasts (CAFs) are abundant cell type TME and have been shown to drive progression several malignancies. The aim current study was...
Background: Programmed cell death 1/programmed ligand 1 (PD-1/PD-L1) immune-checkpoint blockade is a promising new therapeutic strategy in cancer. However, expression patterns and prognostic significance of PD-L1 PD-1 are still controversial human malignant pleural mesothelioma (MPM).Methods: Formalin-fixed paraffin-embedded (FFPE) tumor samples from 203 MPM patients receiving standard treatment without immunotherapy were collected 5 European centers. cells (TCs) tumor-infiltrating...
Although around 30% of patients with gastroesophageal reflux disease (GERD) are insufficiently treated medical therapy, only 1% opt for surgical therapy. One the reasons behind this multifactorial phenomenon is described adverse effect long-term dysphagia or gastric bloating syndrome after treatment. Aim study was to evaluate most common side effects associated anti-reflux surgery, as well outcomes in a large cohort highly surgically standardized laparoscopic Nissen fundoplication (LNF).Out...
The programmed cell death-ligand 1 (PD-L1) protein expression on tumor cells predicts the efficacy of immunotherapy in patients with non-small lung cancer. However, assessment PD-L1 has limited power for selecting due to intra-tumoral heterogeneity and inter-tumoral expression, inter-observer variability scoring staining, reproducibility. These difficulties pitfalls interpreting are discussed detail this review.
There is lack of consensus whether neoadjuvant chemoradiotherapy (CHT/RT) superior to chemotherapy (CHT) alone in patients with potentially resectable stage III/N2 non-small-cell lung cancer (NSCLC).
Programmed death-ligand 1 (PD-L1) testing is performed mainly on biopsy specimens in patients with advanced lung cancer. It questionable whether the small amount of tissue analysed biopsies may represent true PD-L1 expression a tumour.In this retrospective study, tumour cells derived from bronchoscopy brush cytology, endobronchial ultrasound guided transbronchial needle aspiration (EBUS-TBNA), biopsy, (TBB) and computed tomography (CT)-guided transthoracic was compared to corresponding...
Magnetic sphincter augmentation (MSA) is a modern surgical anti-reflux technique with proven efficacy and low postoperative morbidity in patients acidic reflux. The aim of this retrospective review study was to evaluate the symptomatic outcome MSA weakly From prospectively collected clinical database, comprising all 327 that underwent at our institution, total 67 preoperative reflux measured 24-h impedance-pH-metry were identified. Postoperative gastrointestinal symptoms, proton pump...
Abstract As the incidence of gastroesophageal reflux disease (GERD) is rising, surgical treatment continuously advancing in an effort to minimize side effects, whilst maintaining efficacy. From a database patients that underwent anti-reflux surgery at our institution between 2015 and 2018, last 25 consecutive electrical stimulation (ES), magnetic sphincter augmentation (MSA) Nissen fundoplication (NF), following personalized decision aid, were included comparative analysis. After...
Objectives: The ratio of positive and resected lymph nodes (LN ratio) has been shown to be prognostic in non-small cell lung cancer (NSCLC). Contrary the LN ratio, calculating log-odds (LN-LOR) additionally considers total number nodes. We aim evaluate LN-LOR between as a factor operable NSCLC. Methods: Patients with NSCLC who underwent curative intent lobectomy treated at two high-volume centers were retrospectively studied. was dichotomized according impact on OS further combined N...
Abstract The expression of the programmed cell death protein 1 (PD-1) has been shown to be markedly increased in tumor-infiltrating lymphocytes. However, proportion PD-1 + T cells bronchoalveolar lavage (BAL) lung cancer patients not sufficiently evaluated so far. In this prospective study, CD4 as well CD8 BAL samples, isolated from with cancer, asthma or interstitial disease (ILD), were determined via flow cytometry and compared for differences. Bronchoalveolar was performed 34 (14 10...
<title>Abstract</title> Background: PD-1 (programmed cell death protein-1)/PD-L1 ligand-1) as well IL-10 (interleukin-10)/IL-10R (interleukin-10 receptor) interactions play a major role in tumor immune evasion various malignancies. Several studies investigated the expression of on T lymphocytes pleural effusions (PE) patients with malignant diseases. However, results (MPE) compared to benign PE (BPE) are underreported. Methods: In this prospective study, 51 (median age 66 years, IQR 54–78,...
Zusammenfassung In den vergangenen Jahrzehnten hat sich der Inzidenztrend des Lungenkarzinoms signifikant gewandelt, wobei eine Abnahme Häufigkeit bei Männern und Zunahme Frauen zu verzeichnen sind. Dieser Wandel ist vorrangig auf veränderte Rauchgewohnheiten zurückzuführen, die durch einen Anstieg Nikotinkonsums rückläufigen Trend gekennzeichnet Weitere Erklärungen für Inzidenz sind erhöhte Suszeptibilität karzinogenen Wirkungen aktiven passiven Zigarettenrauchens sowie Luftverschmutzung im...
Abstract PD-1 (programmed cell death protein-1)/PD-L1 ligand 1) as well IL-10 (interleukin-10)/IL-10R (interleukin-10 receptor) interactions play a major role in tumor immune evasion various malignancies. Several studies investigated the expression of on T lymphocytes pleural effusions (PE) patients with malignant diseases. However, results (MPE) compared to benign PE (BPE) are underreported. In this prospective study, 51 (median age 66 years, IQR 54–78, 47% male) or origin at Medical...
Abstract OBJECTIVES In patients with interstitial lung disease (ILD), the diaphragm typically rises as lungs chronically shrink. However, grade of restriction differs in each patient. It is currently unknown, how disparities between actual and predicted recipient total capacity (TLC), impact changes function parameters long-term outcomes following transplantation (LTx). METHODS This retrospective study included 170 LTx for ILD performed a European high-volume center 09/2011 12/2022. The...
Abstract Background Pleural mesothelioma (PM) is a relatively rare malignancy with limited treatment options and dismal prognosis. We have previously found elevated FGF18 expression in PM tissue specimens compared normal mesothelium. The objective of the current study was to further explore role evaluate its suitability as circulating biomarker. Methods mRNA analyzed by real‐time PCR cell lines silico datasets from Cancer Genome Atlas (TCGA). Cell overexpressing were generated retroviral...
The prognostic value of pretreatment and preoperative fibrinogen plasma levels the modified Glasgow score (mGPS) in stage III/N2 non-small cell lung cancer (NSCLC) patients who receive neoadjuvant treatment followed by radical surgery is yet unclear.Fibrinogen mGPS 84 with initial NSCLC, received therapy complete surgical resection from 2002 to 2014 were retrospectively analyzed correlated clinical parameters overall survival (OS). Data using log-rank Cox regression analysis adjusted for...
Abstract Background Although around 30% of patients with gastroesophageal-reflux disease (GERD) are insufficiently treated medical therapy, only 1% opt for surgical therapy. One the reasons behind this multifactorial phenomenon is described adverse effect long term dysphagia or gastric bloating syndrome after treatment. Aim study was to evaluate most common side effects associated anti-reflux surgery, as well outcomes in a large cohort highly surgically standardized laparoscopic Nissen...
Abstract Purposes: Programmed death-ligand 1 (PD-L1) testing is performed mainly on biopsy specimens in patients with advanced lung cancer. It questionable whether the small amount of tissue analysed biopsies may represent true PD-L1 expression a tumour. Methods: In this retrospective study, tumour cells derived from bronchoscopy brush cytology, endobronchial-ultrasound guided transbronchial needle aspiration (EBUS-TBNA), endobronchial biopsy, (TBB) and computed tomography (CT)-guided...