A5001334352- Diabetes, Cardiovascular Risks, and Lipoproteins
- Genetic Associations and Epidemiology
- Diabetes Management and Research
- Liver Disease Diagnosis and Treatment
- Obesity, Physical Activity, Diet
- MicroRNA in disease regulation
- Adipokines, Inflammation, and Metabolic Diseases
- Cancer-related molecular mechanisms research
- Birth, Development, and Health
- Circular RNAs in diseases
- Multiple Sclerosis Research Studies
- Oral microbiology and periodontitis research
- Diabetes and associated disorders
- Folate and B Vitamins Research
- Diabetes Management and Education
- Blood Pressure and Hypertension Studies
- Global Public Health Policies and Epidemiology
- Diet, Metabolism, and Disease
- Chronic Kidney Disease and Diabetes
- HIV-related health complications and treatments
- Epigenetics and DNA Methylation
- Nutritional Studies and Diet
- Lipoproteins and Cardiovascular Health
- RNA modifications and cancer
- Oral Health Pathology and Treatment
Stellenbosch University
2006-2024
Sefako Makgatho Health Sciences University
2022-2024
Cape Peninsula University of Technology
2015-2024
South African Medical Research Council
2016-2024
Response Biomedical (Canada)
2024
Bio-Medical Science (South Korea)
2014
University of Cape Town
2002-2012
New York University Press
2009
Cambridge University Press
2009
National Health Laboratory Service
2006
BackgroundThe 2016 Dar Es Salaam Call to Action on Diabetes and Other non-communicable diseases (NCDs) advocates national multi-sectoral NCD strategies action plans based available data information from countries of sub-Saharan Africa beyond. We estimated trends 1980 2014 in age-standardized mean body mass index (BMI) diabetes prevalence these countries, order assess the co-progression assist policy formulation.
Objective. The coloured population has the second-highest prevalence of diabetes in South Africa. However, data were based on a study conducted almost 20 years ago peri-urban Western Cape. We aimed to determine mellitus and metabolic syndrome an urban Design. In cross-sectional survey, 642 participants aged ≥31 drawn from community Bellville South, Cape Town, mid-January 2008 March 2009. Type 2 was assessed according WHO criteria, International Diabetes Federation (IDF), ATP III 2009 Joint...
Disturbances in the oral microbiome are associated with periodontal disease initiation and progression diabetes mellitus (DM), but how this contributes to cause-and-effect relationship between DM is poorly understood. We examined bacterial composition plaque samples from 128 South Africans across glycemic statuses using 16S rDNA sequencing of regions 2, 3, 4, 6-7, 8, 9. Of 9 phyla identified, Firmicutes, Proteobacteria, Bacteroidetes, Fusobacteria, Actinobacteria made up >98%....
Abstract Diabetes mellitus (DM) is characterized by impaired glucose and insulin metabolism, resulting in chronic hyperglycemia. Hyperglycemia-induced inflammation linked to the onset progression of diabetes. Resveratrol (RES), a polyphenol phytoalexin, studied diabetes therapeutics research. This study evaluates effect RES on metabolism HepG2 cells exposed high glucose. Inflammation metabolism-related genes were investigated using qPCR. Further, inflammatory analyzed applying ELISA Bioplex...
Abstract Background Waist-to-height ratio (WHtR) has been proposed as a simple and effective screening tool for assessing central obesity cardiometabolic risk in both adult pediatric populations. However, evidence suggests that the use of uniform WHtR cut-off 0.50 may not be universally optimal populations globally. We aimed to determine cut-offs children adolescents with increased across different countries worldwide. Methods used ten population-based cross-sectional data on 24,605 aged...
Background HbA1c has been the gold standard for glycaemic control follow-up decades. In 2009, a level of 6.5% (48 mmol/mol) was proposed as diagnostic diabetes. We test this cut-off in our community. Methods Participants (946) from community-based study were screened diabetes using either fasting blood glucose or oral tolerance (OFTT). The tested each group. A receiver operator characteristic (ROC) curve both groups generated to establish an optimal cut-off. Results Our included 224 (23.7%)...
Abstract Background Population-based data on the burden of chronic kidney disease (CKD) in sub-Saharan Africa is still very limited. We assessed prevalence and determinants CKD, evaluated concordance commonly advocated estimators glomerular filtration rate (eGFR) a mixed ancestry population from South Africa. Methods Participants were population-based sample adults selected Bellville-South community metropolitan city Cape Town. eGFR was based Cockroft-Gault (CG), Modification Diet Kidney...
The aim of this pilot study was to assess the 30-year risk for cardiovascular disease (CVD) in South Africa population mixed-ancestry individuals with non-diabetic hyperglycaemia, and undiagnosed self-reported diabetes.Participants were drawn from an urban community Bellville suburb Cape Town.In total, 583 subjects without a history CVD eligible lifetime estimation.Gender-specific prediction calculated using interactive calculator.High (> 20%) evident normoglycaemic younger (under 35...
Factors influencing the increasing prevalence of overweight/obesity among children and adolescents in sub-Saharan Africa remain unclear. We assessed determinants overweight obesity effects on cardio-metabolic profile school learners Western Cape, South Africa.Cross-sectional data were collected from 7 to 18-year-old African attending 14 schools, randomly selected 107 government schools areas. The through stratified random sampling techniques. Logistic regressions used assess its association...
The intent of this study, based on a global multicenter study reference values (RVs) for serum analytes was to explore biological sources variation (SVs) the RVs among 12 countries around world. As described in first part paper, 50 major from 13,396 healthy individuals living were obtained. Analyzed 23 clinical chemistry and 8 measured by immunoturbidimetry. Multiple regression analysis performed each gender, country country, analyte analyte, setting four SVs (age, BMI, levels drinking...
microRNAs (miRNAs) have been touted as potential diagnostic and prognostic biomarkers for various diseases. The aim of the present study was to evaluate value miR-30a-5p miR-182-5p prediabetes screen-detected type 2 diabetes mellitus (T2DM).The included 1270 participants (207 prediabetes, 94 969 normotolerant) from Vascular Metabolic Health (VMH) study. Whole blood levels were quantitated by RT-qPCR. Multivariable logistic regressions used relate miRNAs with or T2DM receiver operating...
Glycated haemoglobin (HbA1c) has shown disagreements with other glycaemic indices; termed the glycation gap. The gap can be influenced by non-glycaemic factors like protein deglycation, through fructosamine 3 kinase (FN3K) enzyme. This cross-sectional study aimed to examine whether single nucleotide polymorphisms (SNPs) in FN3K gene explain Amongst 826 participants, 79.8% were female, 22.3% presented DM and median age was 53 years. results suggest that genetic may influence individuals...
To study the prevalence and different types of human papillomavirus (HPV) in patients with oesophageal cancer from a high risk area South Africa (Transkei).DNA samples 50 paraffin wax embedded tissue sections were analysed by nested polymerase chain reaction (PCR) using degenerate HPV L1 consensus primer pairs MY09/MY11 GP5+/GP6+. Positive PCR subjected to DNA sequence analysis.HPV was detected 23 samples. Sequence analysis revealed that most (11) harboured type 11, whereas other included 39...
Because current tests available for the diagnosis of diabetes have shortcomings, a novel screening method earlier and more efficient detection type 2 would be significant clinical advance.The hexosamine biosynthetic pathway usually acts as fuel sensor, its activation leads to O-linked β-N-acetylglucosamine (O-GlcNAc) modification target proteins (O-GlcNAcylation) in glucose-responsive manner. O-GlcNAc transferase (OGT) O-GlcNAcase (OGA) are responsible addition removal, respectively. higher...
Background The proposed waist-to-height ratio (WHtR) cut-off of 0.5 is less optimal for cardiometabolic risk screening in children many settings. purpose this study was to determine the WHtR from South Africa, and investigate variations by gender, ethnicity residence achieved value. Methods Metabolic syndrome (MetS) components were measured 1272 randomly selected learners, aged 10–16 years, comprising 446 black Africans, 696 mixed-ancestry 130 Caucasians. Youden's index closest-top-left...