A5000884004- Diabetes, Cardiovascular Risks, and Lipoproteins
- Diabetes Management and Research
- Liver Disease Diagnosis and Treatment
- Metabolism and Genetic Disorders
- Diet and metabolism studies
- Lipoproteins and Cardiovascular Health
- Obesity, Physical Activity, Diet
- Electrolyte and hormonal disorders
- Clinical Laboratory Practices and Quality Control
- Adrenal Hormones and Disorders
- Gestational Diabetes Research and Management
- Pituitary Gland Disorders and Treatments
- Growth Hormone and Insulin-like Growth Factors
- Adipokines, Inflammation, and Metabolic Diseases
- Hemoglobinopathies and Related Disorders
- Renal function and acid-base balance
- Diabetes and associated disorders
- Cystic Fibrosis Research Advances
- Paraoxonase enzyme and polymorphisms
- Skin Diseases and Diabetes
- Lysosomal Storage Disorders Research
- Genetic Associations and Epidemiology
- Diabetes Treatment and Management
- Oral Health Pathology and Treatment
- Trypanosoma species research and implications
Right to Care
2019-2022
National Health Laboratory Service
2008-2020
Stellenbosch University
2008-2020
Tygerberg Hospital
2008-2020
The intent of this study, based on a global multicenter study reference values (RVs) for serum analytes was to explore biological sources variation (SVs) the RVs among 12 countries around world. As described in first part paper, 50 major from 13,396 healthy individuals living were obtained. Analyzed 23 clinical chemistry and 8 measured by immunoturbidimetry. Multiple regression analysis performed each gender, country country, analyte analyte, setting four SVs (age, BMI, levels drinking...
The aim of this study was to determine the most common causes hypophosphataemia (<or=0.5 mmol/l) in a hospital population order identify patient groups at risk developing condition.The conducted Tygerberg Hospital, tertiary care centre Western Cape, South Africa. All patients identified with phosphate level <or=0.5 mmol/l during an 18-month period were included study. Medical records these reviewed.Of all requests received for serum determination by laboratory, 2% (861 out 45 394 requests)...
Background The accurate determination of low density lipoprotein cholesterol (LDL-c) is pertinent in clinical practice. Most laboratories employ the Friedewald formula, for convenient estimation LDL-c, despite its shortfalls. Different formulae have been proposed use, more but LDL-c. Here, we compare a new formula recently by de Cordova et al., with that and LDL-c determined homogeneous assay. We also assess performance at very TG levels against modified recommended Ahmadi al. Methods A...
Background Glycated proteins, such as glycated haemoglobin (HbA1c) and albumin (GA%), are increasingly being used for glycaemic control assessment the diagnosis of diabetes mellitus. GA% is an intermediate marker that not influenced by factors affect HbA1c concentrations. The aim this study was to determine reference intervals assess confounding in a well-characterized healthy population South Africa. Methods We measured using enzymatic method on stored serum samples individuals recruited...
Abstract Background Research has suggested that individuals of African descent have lower white cell and neutrophil counts than Caucasians. These differences could lead to incorrect clinical decisions, therefore, ethnic‐specific reference ranges are required. The Western Cape region South Africa is uniquely diverse, comprising Caucasian, Mixed Ancestry those descent. aim this study was compare the full blood count differential across three major ethnic groups residing in area propose...
Background: The L162V single nucleotide polymorphism in PPARA is suggested to play an important role the pathogenesis of type 2 diabetes, obesity, and body fat composition. However, clinical evidence controversial.
Abstract Aim To evaluate point‐of‐care‐testing ( POCT ) for the diagnosis of Type 2 diabetes mellitus 6–12 weeks post‐partum in women with gestational GDM ). Methods Post‐partum glucose assessment (75‐mg oral tolerance test, OGTT was performed prospectively 122 (1 November 2015 to 1 2017) at Tygerberg Hospital, Cape Town, South Africa. Individuals known pre‐existing were excluded. The accuracy and clinical utility (capillary finger‐prick) compared laboratory plasma (hexokinase glucokinase...
Urine dipstick testing for ketones is widely used when diabetic ketoacidosis (DKA) suspected in patients with hyperglycaemia. If urinary are positive, referred further management--often inappropriately, as the test a poor surrogate plasma ketones. Plasma beta-hydroxybutyrate (β-OHB) levels>3 mmol/L diagnostic of DKA, while levels<1 insignificant.To evaluate hand-held electrochemical (point-of-care testing; POCT) ketone monitor and compare it gold-standard manual enzymatic method (MEM)...
Objectives: The purpose of this study was to improve our understanding the prevalence acanthosis nigricans (AN) and its clinical relevance in mixed-ancestry population investigate association with abnormal glucose metabolism, obesity hypertension.Design: This a cross-sectional study.Settings subjects: A total 390 healthy females were recruited from dermatology outpatient clinic at Tygerberg Hospital.Outcomes measured: short questionnaire administered, whereafter participants inspected for...
Serum indices can give valuable information and should be interpreted as a result. Lipaemia influence results through different mechanisms, an important one being the electrolyte exclusion effect. A case of pseudohyponatraemia due to this is reported. 15-year-old female with type 2 diabetes was seen for follow-up. Her biochemistry revealed severe hyponatraemia 118 mmol/L. capillary glucose concentration 13.7 mmol/L corrected sodium 122 lipaemic index 3+ (absolute value 1320) noted, which not...
Objective: Metabolic syndrome (MetS) and its associated cardiovascular risk are on the increase in children. High-sensitivity C-reactive protein (hs-CRP) has emerged as a useful marker for inflammation with atherosclerosis disease. Our aim was to determine distribution of hs-CRP an effort identify MetS variable that is critical modulating plasma CRP levels population South African adolescents. Design: A cross-sectional analytical study design used this investigation, where dependent...
We evaluated the association of indices paraoxonase (PON1) and oxidative status with subclinical cardiovascular disease (CVD) in mixed-ancestry South Africans. Participants were 491 adults (126 men) who stratified by diabetes body mass index (BMI). Carotid intima-media thickness (CIMT) was used as a measure CVD. Indices PON1 determined measuring levels activities (paraoxonase arylesterase) PON1, antioxidant activity (ferric reducing power trolox equivalent capacity), lipid peroxidation...
Non-thyroidal illness syndrome (NTIS) can be defined as the presence of abnormal thyroid function in absence primary dysfunction and is associated with acute illness. Thyroid testing generally not advised critically ill patient. Thyroid-stimulating hormone (TSH) measurement preferred screening test for disease, but results may misleading variable setting critical illness.To describe pattern requests TSH patients admitted to emergency department intensive care units at Tygerberg Hospital,...