A5067930161- Lipoproteins and Cardiovascular Health
- Acute Lymphoblastic Leukemia research
- Diabetes, Cardiovascular Risks, and Lipoproteins
- MicroRNA in disease regulation
- Cancer, Lipids, and Metabolism
- Systemic Lupus Erythematosus Research
- Cancer-related molecular mechanisms research
- Liver Disease Diagnosis and Treatment
- Acute Myocardial Infarction Research
- Folate and B Vitamins Research
- Chronic Lymphocytic Leukemia Research
- Childhood Cancer Survivors' Quality of Life
- Drug Transport and Resistance Mechanisms
- Circular RNAs in diseases
- Pharmacogenetics and Drug Metabolism
- Cholesterol and Lipid Metabolism
- Genetic Associations and Epidemiology
- Adipokines, Inflammation, and Metabolic Diseases
- Health, Environment, Cognitive Aging
- Apelin-related biomedical research
- Statistical Methods and Inference
- Prenatal Screening and Diagnostics
- Pharmacological Effects and Toxicity Studies
- Pesticide Residue Analysis and Safety
- Iron Metabolism and Disorders
P. D. Hinduja Hospital and Medical Research Centre
2012-2024
European Atherosclerosis Society
2021
National Hospital
2009-2018
Background . Metabolic syndrome (MS) is characterised by a constellation of individual risk factors cardiovascular disease. Materials and Methods The current study was population-based survey cohort subjects in the metropolitan city Mumbai. A total 548 subjects, who attended CARDIAC evaluation camp, were recruited study. Participants with complete fasting lipid profiles, blood glucose, known cardiac markers evaluated. Results On applying modified NCEP ATP III, we found out that nearly had at...
The intent of this study, based on a global multicenter study reference values (RVs) for serum analytes was to explore biological sources variation (SVs) the RVs among 12 countries around world. As described in first part paper, 50 major from 13,396 healthy individuals living were obtained. Analyzed 23 clinical chemistry and 8 measured by immunoturbidimetry. Multiple regression analysis performed each gender, country country, analyte analyte, setting four SVs (age, BMI, levels drinking...
Abstract Background and Aim Interindividual variation seen in the thiopurine metabolism is attributed to genetic variant methyltransferase ( TPMT ) gene leading myelosuppression. In Asians, thiopurine‐induced toxicity not completely explained by variants. Literature indicates that a newer nucleoside diphosphate‐linked moiety X‐type motif 15 NUDT15 associated with intolerance. We aimed determine risk allele frequency of its association Indian patients. Methods this pilot study, 69 patients on...
Circulating microRNAs (miRNA) are present in body fluids stable, cell-free form. Likewise, these miRNAs can be identified various stages of coronary artery disease (CAD) such as inflammation, endothelial dysfunction, proliferation and atherosclerosis among others. miRNA expression levels identified.To determine the circulating (miR-126, miR-92, miR-33, miR-145 miR-155) CAD patients Indian origin.miRNA profiling analysis blood plasma was performed by quantitative real-time-PCR (qRT-PCR) 60...
Abstract Background In 2011, the IFCC Committee on Reference Intervals and Decision Limits (C-RIDL) initiated a worldwide multicenter study references values facilitating implementation of country-specific reference intervals (RIs). There has been no well-designed RI in India. This aims to derive RIs for 33 major biochemical analytes carefully selected healthy Indians as defined C-RIDL protocol. Methods A total 512 were recruited. Sera collected from overnight fasting blood samples measured...
Abstract Background: Thiopurine methyltransferase ( TPMT ) gene variants have achieved limited success in predicting the outcome of thiopurine therapy, which shows wide inter-individual variations. The literature indicates a strong association between NUDT15 variant and thiopurine-induced toxicity Asian patients. present study intends to explore role (C415T) Indian patients on therapy. Methods: genotyping were performed using amplification-refractory mutation system-polymerase chain reaction...
Context: Thrombomodulin (TM), a natural anticoagulant have been implicated in the pathogenesis of coronary artery disease (CAD) thus emphasizing its potential role as biomarker.Objectives: To investigate TM genetic variants and soluble (sTM) plasma levels Indian population with CAD.Materials methods: This case–control study involved genotyping entire gene sTM estimation 266 subjects.Results: None four identified significantly increased CAD risk population. However, further subgroup analysis...
Introduction : Development of DNA-based tests for TPMT/DPD polymorphisms can help clinicians and patients to make important decisions about cancer treatment. Also, due lack Indian data, we aimed at the development validation these in patients. Materials Methods Molecular assays were used identifying variations; validated by DNA sequencing. Results have been screening TPMT ∗ 2, 3A, 3B, 3C alleles IVS14+1(G→A) DPD gene. A patient, exhibiting neutropenia on 6-MP was observed be...
Abstract Background Cytochrome P450 2D6 ( CYP2D6 ) allelic distribution exhibits differences amongst worldwide populations. There is lack of data from Mumbai, Western India, on the major alleles *2, *3, *4, *5, *10 and *41, gene multiplication alleles. Hence, present study was undertaken to determine these clinically relevant Methods Fifty-two healthy individuals were screened using TaqMan SNP genotyping copy number variation (CNV) assays by real-time polymerase chain reaction. Results The...
Development of DNA-based tests for TPMT/DPD polymorphisms can help clinicians and patients to make important decisions about cancer treatment. Also, due lack Indian data, we aimed at the development validation these in patients.Molecular assays were used identifying variations; validated by DNA sequencing.Molecular have been screening TPMT*2, *3A, *3B, *3C alleles IVS14+1(G-->A) DPD gene. A patient, exhibiting neutropenia on 6-MP was observed be G460A-homozygote, while, two Acute...
Abstract Background & Aims: Familial hypercholesterolemia (FH) is an autosomal dominant disorder characterized by increased levels of low-density lipoprotein cholesterol (LDL-C). LDL receptor ( LDLR ) gene mutations the primary genetic cause thereby necessitating screening family members for early detection and management. We aim to report Indian with FH harboring a novel pathogenic nonsense mutation in strong likelihood preferential transmission. Methods EDTA blood samples were...
Background: With an increase in the discovery of newer genetic loci/polymorphisms complex multifactorial diseases, there is also increased need for methods that can simultaneously genotype multiple loci a cost-effective manner. Using coronary artery disease (CAD) as model, study aimed to develop in-house multilocus assay simultaneous detection 17 variants 11 genes implicated CAD.Methods: A multiplex polymerase chain reaction (PCR)-based reverse line blot hybridization (MPCR-RLBH) approach...
Thiopurines therapy remains an important armamentarium in treatment of inflammatory bowel disease (IBD). Thiopurine methyltransferase (TPMT) gene testing has not been shown as useful Asian patients the caucasian patients. Recent literature indicates a strong association between newer genetic variant, nucleoside diphosphate - linked moiety X-type motif 15 (NUDT15) and thiopurine-induced toxicity We retrospectively evaluated comparative role TPMT genotype NUDT IBD. As part routine clinical...