A5078518239- Prion Diseases and Protein Misfolding
- Toxic Organic Pollutants Impact
- Thermochemical Biomass Conversion Processes
- Subcritical and Supercritical Water Processes
- Neurological diseases and metabolism
- Effects and risks of endocrine disrupting chemicals
- Coal Combustion and Slurry Processing
- Water Treatment and Disinfection
- Trace Elements in Health
- Phosphorus and nutrient management
- Pharmaceutical and Antibiotic Environmental Impacts
- Water Quality Monitoring and Analysis
- Environmental Chemistry and Analysis
- Marine and coastal ecosystems
- Bacteriophages and microbial interactions
- Hydrology and Watershed Management Studies
- Environmental remediation with nanomaterials
- Ubiquitin and proteasome pathways
- Microplastics and Plastic Pollution
- Microbial bioremediation and biosurfactants
- Water Quality and Pollution Assessment
- Microbial Community Ecology and Physiology
- Monoclonal and Polyclonal Antibodies Research
- Catalytic Alkyne Reactions
- Wastewater Treatment and Nitrogen Removal
Kyoto University
2013-2023
Kyushu University of Health and Welfare
2016-2021
Biotherapy Institute of Japan
2021
Japan Fisheries Research and Education Agency
1997-2020
Quality Research
2003-2020
National Institute for Materials Science
2014-2019
Yamaguchi University
2007-2017
Central Institute for Experimental Animals
2016
University of Tsukuba
2015-2016
National Institute of Animal Health
1969-2015
CLOCK is a positive component of transcription/translation-based negative feedback loop the central circadian oscillator in suprachiasmatic nucleus mammals. To examine CLOCK-regulated transcription peripheral tissues, we performed microarray analyses using liver RNA isolated from Clock mutant mice. We also compared expression profiles with those Cryptochromes (Cry1 and Cry2) double knockout identified more than 100 genes that fluctuated day to night which levels were decreased In...
Sorption coefficients (K(oc) values) of selected endocrine disruptors for a wide variety dissolved organic matter (DOM) were measured using fluorescence quenching and solubility enhancement. 17beta-Estradiol, estriol, 17alpha-ethynylestradiol, p-nonylphenol, p-tert-octylphenol, dibutylphthalate as disruptors. Aldrich humic acid, Suwannee River fulvic acids, Nordic alginic dextran, tannic acid DOM surrogates. The resulting sorption (log K(oc)) independent octanol-water partitioning K(ow)) the...
[Ir(cod)Cl](2)/DPPF or BINAP efficiently catalyzed the cycloaddition of α,ω-diynes with nitriles to give pyridines. The reaction can accommodate a very wide range nitriles. Both aliphatic and aromatic smoothly reacted Ten equivalents unactivated nitrile were enough product in high yield. Aliphatic bearing an acetal amino moiety could be used for reaction. highly regioselective unsymmetrical diyne two different internal alkyne moieties was achieved. observed regioselectivity reasonably...
Neutrophils possess a multicomponent NADPH oxidase system capable of producing large quantities superoxide in process known as the respiratory burst (1). Upon stimulation phagocytic cell, two cytosolic components oxidase, p67(phox) and p47(phax), associate with membrane-bound flavocytochrome b small GTP-binding protein to form functional enzyme complex. Each Phox proteins contains src homology 3 (SH3) domains, which are unknown function but potential mediators protein-protein interactions...
The IFCC Committee on Reference Intervals and Decision Limits coordinated a global multicenter study reference values (RVs) to explore rational harmonizable procedures for derivation of intervals (RIs) investigate the feasibility sharing RIs through evaluation sources variation RVs scale. For common protocol, rather lenient criteria individuals were adopted facilitate harmonized recruitment with planned use latent abnormal exclusion (LAVE) method. As July 2015, 12 countries had completed...
Abstract. The horizontal distribution of radioactive cesium (Cs) derived from the Fukushima Dai-ichi nuclear power plant (FNPP) in North Pacific is still unclear due to limitation direct measurement seawater open ocean. We present result observation Cs surface collected a broad area western and central July 2011, October 2011 2012. also conducted simple particle tracking experiment estimate qualitative spatial Pacific. 134Cs was detected at 94 stations out 123 stations, 137Cs all stations....
Collective cell migration is involved in many biological and pathological processes. Various factors have been shown to regulate the decision migrate collectively or individually, but impact of cell-extracellular matrix (ECM) interactions still debated. Here, we developed a method for analyzing collective by precisely tuning between cells ECM ligands. Gold nanoparticles are arrayed on glass substrate with defined nanometer spacing block copolymer micellar nanolithography (BCML),...
The intent of this study, based on a global multicenter study reference values (RVs) for serum analytes was to explore biological sources variation (SVs) the RVs among 12 countries around world. As described in first part paper, 50 major from 13,396 healthy individuals living were obtained. Analyzed 23 clinical chemistry and 8 measured by immunoturbidimetry. Multiple regression analysis performed each gender, country country, analyte analyte, setting four SVs (age, BMI, levels drinking...
Nin1p, a component of the 26S proteasome Saccharomyces cerevisiae, is required for activation Cdc28p kinase at G1-S-phase and G2-M boundaries. By exploiting temperature-sensitive phenotype nin1-1 mutant, we have screened genes encoding proteins with related functions to Nin1p cloned characterized two new multicopy suppressors, SUN1 SUN2, mutation. can suppress null nin1 mutation, whereas an essential gene, does not. Sun1p 268-amino acid protein which shows strong similarity MBP1 Arabidopsis...
Deposited road particles (DRPs) collected from 13 heavily traveled roadways in an urban area of Southern Lake Biwa, Japan, were analyzed for polycyclic aromatic hydrocarbons (PAHs) seven different particle size fractions (< or = 20 to 1000-2000 microm) and evaluated the aryl hydrocarbon receptor (AhR) ligand activity by using a yeast bioassay. The mean compositions individual PAHs total PAH concentrations 19-21% pyrene, which was most dominant component, 14-16% fluoranthene, 7-13%...
Background: The 2009 Asian multicenter study for derivation of reference intervals (RIs) featured: 1) centralized measurements to exclude reagent-dependent variations; 2) inclusion non-standardized analytes (hormones, tumor makers, etc.) in the target; and 3) cross-check test results between central local laboratories. Transferability centrally derived RIs based on was examined.
Chicken manure feedstocks containing a suspended fine activated carbon catalyst were gasified by supercritical water gasification in an experimental pilot plant. A chicken feedstock of 2 wt% with 0.4 was completely gasified, whereas the same without efficiency only 0.8. 10 5 gasified. Our results indicate that is effective as catalyst. The data also confirm use helps to prevent plugging reactor.
mAbs T1 and T2 were established by immunizing PrP gene ablated mice with recombinant MoPrP of residues 121-231. Both cross-reactive from hamster, sheep, cattle deer. A linear epitope mAb was identified at 137-143 buried in PrP(C) expressed on the cell surface. showed no inhibitory effect accumulation PrP(Sc) cultured scrapie-infected neuroblastoma (ScN2a) cells. In contrast, recognized a discontinuous ranged on, or structured by, 132-217 this exposed surface PrP(C). an excellent vitro 50%...
It has been assumed that the agent causing BSE in cattle is a uniform strain (classical BSE); however, different neuropathological and molecular phenotypes of (atypical BSE) have recently reported. We demonstrated successful transmission L-type-like atypical detected Japan (BSE/JP24 isolate) to cattle. Based on incubation period, hallmarks, properties abnormal host prion protein, characteristics BSE/JP24 were apparently distinguishable from classical closely resemble those bovine amyloidotic...