A5004897651- COVID-19 Clinical Research Studies
- Clinical Laboratory Practices and Quality Control
- Long-Term Effects of COVID-19
- Meta-analysis and systematic reviews
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Healthcare cost, quality, practices
- HIV Research and Treatment
- Sepsis Diagnosis and Treatment
- SARS-CoV-2 and COVID-19 Research
- HIV-related health complications and treatments
- Renal function and acid-base balance
- Diabetes Management and Research
- Clinical Reasoning and Diagnostic Skills
- Consumer Attitudes and Food Labeling
- COVID-19 and healthcare impacts
- Agriculture Sustainability and Environmental Impact
- Multiple Myeloma Research and Treatments
- Vitamin D Research Studies
- Global Public Health Policies and Epidemiology
- HIV/AIDS Research and Interventions
- Nutritional Studies and Diet
- Folate and B Vitamins Research
- Liver Disease Diagnosis and Treatment
- Chronic Kidney Disease and Diabetes
- Electrolyte and hormonal disorders
Stellenbosch University
2015-2024
National Health Laboratory Service
2015-2024
Tygerberg Hospital
2015-2024
Response Biomedical (Canada)
2024
Western Cape Department of Health
2020
During the outbreak of coronavirus disease 2019 (COVID-19), many studies have investigated laboratory biomarkers in management and prognostication COVID-19 patients, however to date, few arterial blood gas, acid-base pressure patterns. The aim study is assess gas patterns, findings their association with outcomes patients admitted an intensive care unit.A single-centre retrospective, observational a dedicated unit Cape Town, South Africa. Admission serum electrolytes, renal function readings...
Background HbA1c has been the gold standard for glycaemic control follow-up decades. In 2009, a level of 6.5% (48 mmol/mol) was proposed as diagnostic diabetes. We test this cut-off in our community. Methods Participants (946) from community-based study were screened diabetes using either fasting blood glucose or oral tolerance (OFTT). The tested each group. A receiver operator characteristic (ROC) curve both groups generated to establish an optimal cut-off. Results Our included 224 (23.7%)...
Glycated haemoglobin (HbA1c) has shown disagreements with other glycaemic indices; termed the glycation gap. The gap can be influenced by non-glycaemic factors like protein deglycation, through fructosamine 3 kinase (FN3K) enzyme. This cross-sectional study aimed to examine whether single nucleotide polymorphisms (SNPs) in FN3K gene explain Amongst 826 participants, 79.8% were female, 22.3% presented DM and median age was 53 years. results suggest that genetic may influence individuals...
<p dir="ltr">Glycated haemoglobin (HbA1c) has shown disagreements with other glycaemic indices; termed the glycation gap. The gap can be influenced by non-glycaemic factors like protein deglycation, through fructosamine 3 kinase (FN3K) enzyme. This cross-sectional study aimed to examine whether single nucleotide polymorphisms (SNPs) in FN3K gene explain Amongst 826 participants, 79.8% were female, 22.3% presented DM and median age was 53 years. results suggest that genetic may...
<p dir="ltr">Glycated haemoglobin (HbA1c) has shown disagreements with other glycaemic indices; termed the glycation gap. The gap can be influenced by non-glycaemic factors like protein deglycation, through fructosamine 3 kinase (FN3K) enzyme. This cross-sectional study aimed to examine whether single nucleotide polymorphisms (SNPs) in FN3K gene explain Amongst 826 participants, 79.8% were female, 22.3% presented DM and median age was 53 years. results suggest that genetic may...
The aim of this study was to determine the most common causes hypophosphataemia (<or=0.5 mmol/l) in a hospital population order identify patient groups at risk developing condition.The conducted Tygerberg Hospital, tertiary care centre Western Cape, South Africa. All patients identified with phosphate level <or=0.5 mmol/l during an 18-month period were included study. Medical records these reviewed.Of all requests received for serum determination by laboratory, 2% (861 out 45 394 requests)...
Research has demonstrated that most laboratory errors occur in the preanalytical phase of testing. In view paucity studies examining errors, we evaluated our request forms for frequency and impact incomplete data.This study examined all received at during a five-day period. The were scrutinized presence specific parameters. abbreviated diagnoses was analysed, as well how lack ward or telephone details affects communication critical results to clinicians.A total 2550 analysed. Medication(s)...
Abstract Recent publications report that up to 70% of total laboratory errors occur in the pre-analytical phase. Identification specific problems highlights pre-analytic processes susceptible errors. The rejection unsuitable samples can lead delayed turnaround time and affect patient care. A retrospective audit was conducted investigating rate routine blood specimens received at chemistry haematology laboratories over a 2-week period. reasons for potential clinical impact these rejections...
ABSTRACTBackground Pathology-supported genetic testing (PSGT) enables transitioning of risk stratification from the study population to individual.Research Design and Methods We provide an overview translational research performed in postmenopausal breast cancer patients at increased osteoporosis due aromatase inhibitor therapy, as indication for referral. Both tumor histopathology blood biochemistry levels were assessed identify actionable disease pathways using whole exome sequencing...
Data on biochemical markers and their association with mortality rates in patients severe coronavirus disease 2019 (COVID-19) admitted to intensive care units (ICUs) sub-Saharan Africa are scarce. An evaluation of baseline routine parameters was performed COVID-19 the ICU, order identify prognostic biomarkers. Demographic, clinical, laboratory data were collected prospectively from PCR-confirmed adult ICU a tertiary hospital Cape Town, South Africa, between October 2020 February 2021. Robust...
The second wave of coronavirus disease 2019 (COVID-19) in South Africa was caused by the Beta variant severe acute respiratory syndrome coronavirurus-2. This study aimed to explore clinical and biochemical parameters that could predict outcome patients with COVID-19. A prospective conducted between 5 November 2020 30 April 2021 among confirmed COVID-19 admitted intensive care unit (ICU) a tertiary hospital. Cox proportional hazards model Stata 16 used assess risk factors associated survival...
Abstract Background The coronavirus disease 2019 (COVID-19) pandemic continues to evolve. Globally, COVID-19 strain even the most resilient healthcare systems, with Omicron being latest variant. We made a thorough search for literature describing effects of in high human immunodeficiency virus (HIV)/tuberculosis (TB) burden district-level hospital setting. found scanty literature. Methods A retrospective observational study was conducted at Khayelitsha District Hospital Cape Town, South...
Abstract Asymptomatic primary hyperparathyroidism (PHPT) is often missed in developing nations due to limited formal healthcare exposure and biochemical screening programs. Many patients are thus only diagnosed once symptomatic. We present a 32-year-old female who developed bony protrusions her jaw during pregnancy, resulting stillbirth. Three months later, dental consultation for worsening toothache, abnormalities were detected. Radiological studies revealed bilateral mandibular radiolucent...