A5070903658- Ethnobotanical and Medicinal Plants Studies
- Natural Antidiabetic Agents Studies
- Essential Oils and Antimicrobial Activity
- African Botany and Ecology Studies
- Liver Disease Diagnosis and Treatment
- Alzheimer's disease research and treatments
- Natural product bioactivities and synthesis
- Pancreatic function and diabetes
- Pesticide Exposure and Toxicity
- Metabolism, Diabetes, and Cancer
- Phytochemistry and Bioactive Compounds
- Ginger and Zingiberaceae research
- Medicinal Plants and Neuroprotection
- Academic Writing and Publishing
- Genetics, Bioinformatics, and Biomedical Research
- Diet, Metabolism, and Disease
- Cholinesterase and Neurodegenerative Diseases
- Pharmacological Effects of Natural Compounds
- Tryptophan and brain disorders
- Nutrition, Genetics, and Disease
- Papaya Research and Applications
- Pharmacological Effects of Medicinal Plants
- Effects and risks of endocrine disrupting chemicals
- Livestock and Poultry Management
- Chemotherapy-induced organ toxicity mitigation
Kampala International University
2023-2025
Usmanu Danfodiyo University
2014-2024
Western International University
2023
Université de Yaoundé I
2020
Jamia Hamdard
2012-2019
Kebbi State University of Science and Technology
2019
Lagos State Health Service Commission
2018
Federal University of Agriculture
2018
Hamdard University
2013
Dried flower bud of Syzygium aromaticum (clove) is rich in eugenol, an antioxidant and antiinflammatory compound that can protect liver against injury. Clove, besides also contains other pharmacologically active phytochemicals such as β-sitosterol ascorbic acid. This study reports the effect eugenol-rich fraction (ERF) clove on cirrhosis induced by thioacetamide.Cirrhosis liver, which predisposes to hepatocellular carcinoma, was administering thioacetamide (0.03%) drinking water for 16...
Pesticide exposure may induce biochemical alterations including oxidative stress and lipid peroxidation. However, in the context of developmental origin health disease, putative trans-generational effect to pesticides are insufficiently studied. We therefore aimed evaluate gestational four on female Wistar rats their offspring at adult age. studied 30 nulliparous divided into 5 equal groups. Group 1 served as control group received distilled water while 2, 3, 4 orally pesticide...
Diabetes is a metabolic disorder whose complications are among the leading cause of death. In this study, antidiabetic effect L-alanine was tested in alloxan-induced diabetic rats. Thirty-five male albino Wistar rats were divided into five groups viz; Group I and II: nondiabetic controls respectively; III IV: 150 300 mg/kg b.w. treated, V: glibenclamide (0.5 b.w.) treated. Weight blood glucose monitored during while liver kidney functions, lipid profile, antioxidant markers examined at end...
Abstract Ethnopharmacological relevance For decades, patients in East Africa have used herbal medicine as an alternative and affordable therapeutic option for the treatment of diseases such Diabetes Mellitus (DM). As a result, primary objective this research was to thoroughly investigate plants employed treating DM Uganda, Tanzania, Kenya, Democratic Republic Congo gather pertinent ethnopharmacological ethnomedicinal knowledge that could be applied development therapies DM. Aim study The is...
This study reports the beneficial effect of aqueous extract dried flower buds Syzygium aromaticum (clove) in acute and chronic inflammation. Inflammation was induced rats by injecting carrageenan hind paw or implanting cotton pellet axilla. Administration (1 g/kg body weight) inhibited formation oedema decreased granuloma model. The extract, when compared with disease control, is reported to decrease elevated levels succinate dehydrogenase (p<0.001), xanthine oxidase (p<0.05) lipid...
Arthritis is one of the leading causes disability among millions people in Nigeria. The limitations use conventional analgesic and anti-inflammatory drugs for management arthritis include their exorbitant costs, adverse effects inability to permanently resolve cases hence need alternatives. Research on herbal remedies effective has grown recent years a bid find leads new bioactive compounds. This study was aimed at documenting validating medicinal plant species used traditionally North-West...
The most rampant and complex form of dementia is Alzheimer's disease (AD) which characterized by various cognitive deficits personality abnormalities. AD a neurodegenerative condition marked the buildup beta-amyloid peptide fragments Tau protein in tangles brain neurons. presence β-amyloid peptide, protein, oxidative stress, an aggravated neuro-inflammatory response are all part its pathophysiological pathway. Quite number invertebrates have been genetically modified such that they express...
Context: Mineral pitch (MP), a traditional medicine, is proposed to boost immunity in conditions that suppress Th1 cytokines such as AIDS/HIV, tuberculosis, leishmaniasis and cancer.Objective: This study investigates the immunoregulatory mechanisms of MP innate, humoral cell-mediated immunity.Materials methods: Mice given (100, 200, 300 or 400 mg/kg, orally) for 10 consecutive days were immunized intravenously with goat RBC ovalbumin, investigated plaque-forming cells (PFC), hemagglutination...
Background: Highly Active Antiretroviral Therapy (HAART) has been linked to oxidative damage kidney cells leading renal disease in people living with HIV/AIDS on HAART treatment. The toxic effects of affect the patients’ quality life poor adherence their regimen. Therefore, purpose this study was investigate nephron-protective activity methanol crude peel extract Punica granatum (MPEPG) HAART-administered Wistar rats. Methods: Thirty male albino rats weighing between 180– 200g were randomly...
Zinc deficiency is a common nutritional disorder with detrimental health consequences. Whether parental zinc induces intergenerational effects remains largely unknown. We investigated the of combined maternal and paternal on offspring’s metabolic outcomes gene expression changes in Drosophila melanogaster. The parent flies were raised zinc-deficient diets throughout development, their progeny assessed. Offspring from zinc-deprived parents exhibited significant (p < 0.05) increase body...
This study identifies and validates hexokinase type 4 (HK4), an isozyme of in the liver pancreas, as important target C2-β-D-glucopyranosyl-1,3,6,7-tetrahydroxyxanthone (βdGT), a xanthone glucoside suggested to have antidiabetic property. In study, we applied computational pipeline molecular docking followed by dynamics simulations shortlist potential βdGT protein targets. The analysis binding free energy (ΔG) led us identification HK4 key target, whereby mode domain activator function βdGT....