A5031679757- Gout, Hyperuricemia, Uric Acid
- Inflammatory Bowel Disease
- Potassium and Related Disorders
- Nutrition, Health and Food Behavior
- Blood transfusion and management
- Heart Failure Treatment and Management
- Diet, Metabolism, and Disease
- Diabetes and associated disorders
- Cardiac and Coronary Surgery Techniques
- Vasculitis and related conditions
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Tumors and Oncological Cases
- Diverticular Disease and Complications
- Pharmacology and Obesity Treatment
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Folate and B Vitamins Research
- Primary Care and Health Outcomes
- Pneumocystis jirovecii pneumonia detection and treatment
- Methemoglobinemia and Tumor Lysis Syndrome
- Chromatin Remodeling and Cancer
- Biomedical Research and Pathophysiology
- Maternal and fetal healthcare
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Blood donation and transfusion practices
- Alcohol Consumption and Health Effects
Prince Charles Hospital
2023-2024
Princess Alexandra Hospital
2023-2024
The University of Sydney
2023-2024
Research Canada
2020-2024
The University of Queensland
2023-2024
Prince Charles Hospital
2023
Bayero University Kano
2017
Aminu Kano Teaching Hospital
2017
University of Florida
2000
Most data on mortality and prognostic factors in patients with heart failure come from North America Europe, little information other regions. Here, the International Congestive Heart Failure (INTER-CHF) study, we aimed to measure at 1 year Africa, China, India, Middle East, southeast Asia South America; also explored demographic, clinical, socioeconomic variables associated mortality.We enrolled consecutive (3695 [66%] clinic outpatients, 2105 [34%] hospital patients) 108 centres six...
Atypical teratoma/rhabdoid tumor (AT/RT) of the central nervous system is a highly malignant neoplasm in infants and early childhood. Approximately one third patients develop intracranial dissemination with involvement cerebral spinal fluid (CSF). The clinical, radiological, pathological features have been described, but cytology cells CSF has not. Multiple samples were examined case AT/RT 2-yr-old girl. most consistent cytologic are large size cells, eccentricity nuclei, prominent nucleoli....
Abstract Background Canada is currently in the third epidemiological stage evolution of IBD: compounding prevalence. A high incidence IBD, conjunction with low mortality, leads to a steadily rising prevalence over time. By understanding historical trends, we can forecast and into future inform healthcare systems burden IBD society. Purpose To analyze past trends order overall Crohn’s disease (CD), ulcerative colitis (UC) stratified by age (<18, 18-64, 65+). Method Canadian...
<h3>Background:</h3> Gout and type 2 diabetes are both common independent risk factors for nephrolithiasis (e.g., 24% of US adults with gout have had nephrolithiasis, vs. 8% without gout[1]). Sodium-glucose cotransporter-2 inhibitors (SGLT2i) increase urinary flow osmotic diuresis uric acid excretion (and thereby lower serum urate levels), which could impact risk, although potentially in opposing directions. However, outcome data SGLT2i limited, particularly among the highest patients...
<h3>Background:</h3> Sodium-Glucose Cotransporter Type 2 Inhibitors (SGLT2i) are a revolutionary second-line treatment for type diabetes (T2D) with cardiovascular, kidney, and serum urate-lowering benefits. <h3>Objectives:</h3> To emulate the idealized target trials examining head-to-head comparative effectiveness of initiation SGLT2i vs. sulfonylurea (most common glucose-lowering therapy in US[1] Canada[2]), when added to metformin monotherapy, risk incident gout rate recurrent flares....
Background: A U-shaped relationship may exist between serum urate (SU) and cardiovascular events, although the SU mortality is unclear. The most recent EULAR recommendations for gout advise against maintaining <3 mg/dl prolonged periods. Objectives: To examine all-cause cause-specific in large cohorts United States (US). Methods: We examined National Health Nutrition Examination Survey (NHANES) data from 1988-1994 (NHANES III) 1999-2007 including subjects aged ≥18 with an enrollment...
Abstract Background Inflammatory bowel disease (IBD) is a costly to manage due hospitalizations, regular ambulatory monitoring, and expensive pharmaceutical therapies. While hospitalization rates have fallen, the increased use of biologics escalated cost care healthcare system. Purpose To assess historical direct costs IBD population in Canada. Method Population-based administrative costing data were obtained from: Alberta, British Columbia, Manitoba. Costs calculated based on (2009 2016)...
Abstract Background Hospitalizations pose a significant burden on both the individual and healthcare system. Those with inflammatory bowel disease (IBD) are at increased risk of hospitalization as compared to general population due flaring activity complications related IBD. The advent biologics over past twenty years may have influenced rates for Purpose To assess current forecast overall those IBD stratified by types hospitalizations (all cause hospitalizations, IBD-related, IBD-specific)....
<h3>Background</h3> Sodium-Glucose Cotransporter Type 2 Inhibitors (SGLT2i) are a revolutionary second-line treatment for type diabetes associated with lower risk of cardiovascular and all-cause mortality, heart failure, chronic kidney disease progression. Many trials have also found SGLT2i serum urate levels. However, data on gout limited the few available prior studies were not specific to those using metformin, primary target populations recent landmark like GRADE. <h3>Objectives</h3> To...
<h3>Background</h3> A recent UK study reported a higher cardiovascular event risk after gout flare episodes,<sup>[1]</sup> which may translate to premature mortality for patients over the long term. Prior studies in gout, but did not compare demographic subgroups, and it is unknown whether excess has improved years at national level. <h3>Objectives</h3> We prospectively evaluated association between of all-cause latest US general population data compared with prior data. <h3>Methods</h3>...
Background: Fast food consumption has strong positive associations with weight gain and insulin resistance. 1 Obesity resistance are in turn strongly associated elevated serum urate (SU) levels, largely mediated by insulin’s anti-uricosuric ability. 2 Objectives: To investigate the relation between fast changes SU over a 15-year period among young black white adults United States. Methods: Participants for CARDIA study included 3,122 (age 18-30 years 1985-86) States who were followed up...
Background Traditionally viewed as a disease of White men, global frequency and disability burden female gout are rising disproportionately to male gout. 1 Moreover, emerging US cohort data suggest hyperuricemia impart larger burdens on Black adults than Whites. 2 These racial disparities may be largely attributable differences in non-genetic, mainly modifiable risk factors e.g., BMI, diet, 3,4 chronic kidney (CKD). However, national-level, general population gout, potential mediators,...
Background: Emerging evidence suggests inflammation may drive progression from hyperuricemia to clinical gout, but the role of extrinsic, modifiable sources chronic inflammation, such as diet, on gout risk is unknown. Notably, greater dietary inflammatory potential has been independently associated with increased incident cardiovascular disease (CVD) 1 and type 2 diabetes (T2D). Objectives: Prospectively examine relation between in three large cohorts US women men over 30 years. Methods:...
<h3>Background</h3> ANCA-associated vasculitis (AAV) is associated with severe end-organ damage (e.g., renal failure) and treatment-related complications infection) which often lead to hospitalization. However, no data on recent hospitalization trends mortality are available<sup>1</sup>. <h3>Objectives</h3> We evaluated in nationwide hospitalization, cost, in-hospital among patients AAV. <h3>Methods</h3> used the National Inpatient Survey (NIS) largest all-payer inpatient database US....
<h3>Background</h3> Gout flares may increase risk of cardiovascular events.<sup>[1]</sup> Sodium-glucose cotransporter-2 inhibitors (SGLT2i) are associated with lower incident gout (primary prevention); however, their role in recurrent among patients (secondary prevention), and remains unknown. <h3>Objectives</h3> To assess rate prevalent type 2 diabetes initiating SGLT2i versus dipeptidyl peptidase-4 (DPP4i), two second-line glucose-lowering agents for diabetes. <h3>Methods</h3> This...
To investigate associations between transfusion of blood products close to the end shelf-life and clinical outcomes in obstetric inpatients.
BackgroundBlood transfusion is common among patients undergoing vascular procedures. However, little known about the effects of blood product storage duration on patients. We investigated transfusing products close to expiration date (i.e., ≥35 days packed red cells (PRBCs) and >3 platelets (PLTs)) patients.MethodsWe retrospectively examined all PRBCs PLTs transfused in receiving procedures without cardiopulmonary bypass Queensland from 2007 2013. Mortality, length stay (LOS) quantity were...
Background: Idiopathic inflammatory myopathy (IIM) is associated with significant premature mortality; however, whether the mortality gap has improved over recent years unknown. Objectives: To determine trends in patients IIM a large cohort, representative of United Kingdom (UK) general population. Methods: Using The Health Improvement Network (THIN), an electronic medical record database UK population, we identified incident between 18 and 89 age (defined by at least one Read diagnosis code...
Background Several studies published after 2010 reported a higher frequency of gout and hyperuricemia among US Blacks than Whites. 1-4 However, (in the Africa) were previously thought to suffer less often 5 We hypothesized that racial disparity in emerged over past several decades, with flipped prevalence between two races. Objectives To assess trends differences using both national survey cohort study data 3 decades. Methods Using from NHANES (National Health Nutrition Examination Survey)...
Background Serum urate (SU) is a necessary causal factor for development of gout, while chronic kidney disease (CKD) associated with increased inflammatory biomarkers, cytokines, and reduced AMPK activity levels. Furthermore, CKD has been found to be an risk incident even beyond (i.e., independent of) SU As such, the impact may enhanced by presence CKD, but this hypothesis not evaluated. Objectives To prospectively examine whether modifies relation between levels gout. Methods We conducted...
Background: Although gout is conventionally known as a male condition, the recent Global Burden of Disease (GBD) Study found disproportionate worsening among women. 1 We have Dietary Approaches to Stop Hypertension (DASH) diet independently associated with lower risk incident gout, while Western increased risk. 2 Whether these risks vary according genetic remains unknown. Objectives: To investigate influence predisposition on relation between diets (one protective and another hazardous) in...
Background: Global burden of gout has increased substantially, particularly among women. 1,2 Addressing obesity, a major modifiable risk factor for gout, may alleviate this burden; however, there is also significant genetic contribution to according the genome-wide association studies (GWAS). 3,4 Genetic predisposition modify excess weight effect on risk. Objectives: To investigate potential role between (i.e., BMI ≥ 25 kg/m 2 ) and in two US prospective longitudinal cohorts over >26...