A5053377912- Multiple Myeloma Research and Treatments
- Cancer Genomics and Diagnostics
- Acute Myeloid Leukemia Research
- Lung Cancer Treatments and Mutations
- Cancer Immunotherapy and Biomarkers
- Chronic Lymphocytic Leukemia Research
- RNA modifications and cancer
- Esophageal Cancer Research and Treatment
- Chronic Myeloid Leukemia Treatments
- Retinal Diseases and Treatments
- Retinal Imaging and Analysis
- Histone Deacetylase Inhibitors Research
- Retinal and Optic Conditions
- Laser Applications in Dentistry and Medicine
- MicroRNA in disease regulation
- Hearing, Cochlea, Tinnitus, Genetics
- Immunotherapy and Immune Responses
- Computational Drug Discovery Methods
- Gastric Cancer Management and Outcomes
- Neutropenia and Cancer Infections
- Circular RNAs in diseases
- Systemic Lupus Erythematosus Research
- Ion Channels and Receptors
- Cancer Cells and Metastasis
- Multiple and Secondary Primary Cancers
The University of Texas Health Science Center at Houston
2023-2025
The University of Texas MD Anderson Cancer Center
2023-2025
Khyber Medical University
2025
University of the Punjab
2023-2024
National University of Sciences and Technology
2020-2024
Hayatabad Medical Complex
2024
Amsterdam University Medical Centers
2019-2023
Kuwait Cancer Control Center
2023
Ain Shams University
2023
Institut Paoli-Calmettes
2023
The prognostic impact of additional copies chromosome 1q (1q + ) on outcomes newly-diagnosed multiple myeloma (NDMM) patients undergoing autologous transplantation (autoSCT) is unclear. We conducted a retrospective single-center analysis NDMM with 1q21 gain/amplification (3 or ≥4 1q, respectively) that received autoSCT between 2008-2018. 213 were included (79% gain; 21% amplification). most commonly used induction regimen was bortezomib, lenalidomide, and dexamethasone (41%). At day100...
Autologous stem cell transplantation (autoHCT) is considered standard of care for newly diagnosed multiple myeloma (MM). Although most patients eventually progress after autoHCT, a small proportion achieve durable response. In this retrospective study we included 1576 patients, 244 (15%) whom were long-term responders (LTR), defined as having progression-free survival (PFS) ≥8 years transplant. Patients in the LTR group younger than non-LTR (median age 58.4 vs. 59.5 years; p = 0.012), less...
Summary There are scarce data in the literature focusing on newly diagnosed multiple myeloma (NDMM) patients who undergo autologous haematopoietic cell transplantation (autoHCT) after achieving suboptimal response to induction. To address this, we performed a retrospective, single‐centre analysis of with NDMM underwent upfront autoHCT between 2005 and 2021 pretransplant less than very good partial (<VGPR). Primary outcomes were progression‐free survival (PFS) overall (OS). 1109 included...
Abstract Identification of genes associated with nonsyndromic hearing loss is a crucial endeavor given the substantial number individuals who remain without diagnosis after even most advanced genetic testing. PKHD1L1 was established as necessary for formation cochlear hair-cell stereociliary coat and causes in mice zebrafish when mutated. We sought to determine if biallelic variants also cause humans. Exome sequencing performed on DNA four families segregating autosomal recessive...
Inflammatory cascade plays a pivotal role in the onset and progression of major depressive disorder (MDD) glioblastoma multiforme (GBM). Therefore, questing natural compounds with anti-inflammatory activity such as diosgenin can act double-edged sword targeting cancer cancer-induced inflammation simultaneously. The blood-brain barrier limits therapeutic efficiency drugs against intracranial pathologies including depression brain cancers. Encapsulating drug molecule lipid nanoparticles...
Symptoms secondary to hormonal changes significantly impact quality of life (QoL) in patients with cancer. This cross-sectional study examines prevalence hypogonadism and its correlation QoL sexual dysfunction.We collected blood medical histories from 428 male non-testosterone-related cancer at three centers. Serum was analyzed for total testosterone (TT), free (FT), bioavailable (BAT), sex hormone binding globulin (SHBG). The Functional Assessment Cancer Therapy-Prostate (FACT-P)...
Abstract Background Dysregulation of the host immune response is a pathognomonic feature sepsis. Abnormal physiological conditions are understood to shift efficient linear splicing protein-coding RNA towards non-canonical splicing, characterized by accumulation non-coding circularized (circ)RNA. CircRNAs remain unexplored in specific peripheral blood mononuclear cells (PBMCs) during We here sought identify and characterize circRNA expression PBMCs patients with sepsis due community-acquired...
This observational study investigated the changes in choroidal thickness (ChT) different patterns of diabetic macular edema (DME) based on image processing using enhanced-depth imaging spectral-domain optical coherence tomography (EDI-SD-OCT). Participants with ocular conditions affecting fundus view, including retinal diseases, were excluded. After observing patient's medical record, multicolor photos, maps, and subtypes DME diagnosed according to criteria reported by Early Treatment...
The host immune response is characterized by a complex interplay of signal-specific cellular transcriptional responses. magnitude the dependent on strength external stimulus. Knowledge leukocyte responses altered in to different stimulus dosages man lacking. Here, we sought identify signatures LPS dose humans. Healthy human volunteers were administered 1 ng/kg (n = 7), 2 6), or 4 7) intravenously. Blood was collected before (pre-LPS) and h after administration. Total RNA analyzed microarrays...
Abstract DNA damage is a causative factor in ageing of the vasculature and other organs. One most important vascular features reduced nitric oxide (NO)soluble guanylate cyclase (sGC)—cyclic guanosine monophosphate (cGMP) signaling. We hypothesized that restoration NO‐sGC‐cGMP signaling with an sGC activator (BAY 54–6544) may have beneficial effects on premature death repair‐defective mice undergoing accelerated ageing. Eight weeks treatment non‐pressor dosage BAY 54–6544 restored decreased...
Abstract Background The prognostic significance of minimal residual disease (MRD) status before autologous hematopoietic stem cell transplantation (autoHCT) in patients with multiple myeloma (MM) has not been clearly elucidated. Methods Retrospective single‐center study adult MM who achieved ≥very good partial response (VGPR) after induction therapy from 2015 to 2021 received upfront autoHCT and had available pretransplant MRD by next‐generation flow cytometry. cohort was divided into...
Monocytes are key players in innate immunity, with their ability to regulate inflammatory responses and combat invading pathogens. There is a growing body of evidence indicating that long non-coding RNA (lncRNA) participate various cellular biological processes, including the immune response. The immunoregulatory properties numerous lncRNAs discovered monocytes remain largely unexplored. Here, by sequencing, we identified lncRNA JHDM1D-AS1, which was upregulated blood obtained from patients...
Global health estimates indicated approximately 322 million people living with depression. Rising cost of depressive illness treatment and non-responsiveness to existing therapies demand continued research explore new more potent therapies. Exploring the potential natural compounds for their antidepressant potentials is becoming topic interest scientists. Anti-inflammatory activity thymoquinone, active ingredient Nigella sativa, has been well documented. Current study tested thymoquinone its...
Esophageal adenocarcinoma (EAC) is a highly aggressive cancer and its response to chemo- radiotherapy unpredictable. EACs are heterogeneous at the molecular level. The aim of this study was perform gene expression analysis identify distinct subgroups investigate signatures in relation treatment response. In prospective observational study, RNA sequencing performed on pre-treatment endoscopic EAC biopsies from discovery cohort included between 2012 2017 one Dutch Academic Center. Four...
Our previous work identified human immunodeficiency virus type I enhancer binding protein 1 (HIVEP1) as a putative driver of LPS-induced NF-κB signaling in humans vivo . While HIVEP1 is known to interact with NF-ĸB DNA motifs, its function mammalian cells unknown. We report increased mRNA expression monocytes from patients sepsis and stimulated by Toll-like receptor agonists bacteria. In complementary overexpression gene deletion experiments was shown inhibit activity induction responsive...
Identification of genes associated with nonsyndromic hearing loss is a crucial endeavor given the substantial number individuals who remain without diagnosis after even most advanced genetic testing.