A5069097413- Hepatitis B Virus Studies
- Metal complexes synthesis and properties
- HIV Research and Treatment
- Hepatitis C virus research
- Immune Cell Function and Interaction
- Synthesis and Characterization of Heterocyclic Compounds
- Synthesis and biological activity
- Crystal structures of chemical compounds
- Organometallic Compounds Synthesis and Characterization
- Cancer therapeutics and mechanisms
- Liver Disease Diagnosis and Treatment
- Glycosylation and Glycoproteins Research
- Mosquito-borne diseases and control
- Nanoparticles: synthesis and applications
- SARS-CoV-2 detection and testing
- Cancer Research and Treatments
- Cervical Cancer and HPV Research
- Medicinal Plants and Neuroprotection
- Free Radicals and Antioxidants
- Advanced Glycation End Products research
- Gene expression and cancer classification
- SARS-CoV-2 and COVID-19 Research
- Genetic Associations and Epidemiology
- vaccines and immunoinformatics approaches
- Advanced biosensing and bioanalysis techniques
National University of Sciences and Technology
2016-2025
Quaid-i-Azam University
2021
Harvard University
2018-2020
German Primate Center
2015-2016
University of the Sciences
2015
Bionanotechnology is the combination of biotechnology and nanotechnology for development biosynthetic environmentally friendly nanomaterial synthesis technology. The presented research work adopted a reliable sustainable approach to manufacturing silver nanoparticles from Brachychiton populneus (BP-AgNPs) leaf extract in aqueous medium. populneus-derived were characterized by UV–Vis spectroscopy, Fourier-transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), energy...
Tissue engineering is currently one of the fastest-growing areas engineering, requiring fabrication advanced and multifunctional materials that can be used as scaffolds or dressings for tissue regeneration. In this work, we report a bilayer material prepared by electrospinning hybrid poly(vinyl alcohol) (PVA) bacterial cellulose (BC NFs) (top layer) over highly interconnected porous 3D gelatin-PVA hydrogel obtained freeze-drying process (bottom layer). The techniques were combined to produce...
Malignant melanoma is a lethal human skin cancer that not easily treatable through traditional medicines, surgeries, and therapies. Millions of cases are recorded annually to cure physiological defects by chemotherapy causes several adverse effects challenges. Moreover, pathogenic infections might aggravate infection with subsequent ulceration or cutaneous melanoma. Accordingly, we synthesized nanodrug loading chemotherapeutic agent, Fluorouracil (5FU), onto the reduced graphene oxide (rGO)....
Due to their potential renewable materials-based tissue engineering scaffolds has gained more attention. Therefore, researchers are looking for new materials be used as a scaffold. In this study, we have focused on the development of nanocomposite scaffold bone (using bacterial cellulose (BC) and β-glucan (β-G)) via free radical polymerization freeze-drying technique. Hydroxyapatite nanoparticles (n-HAp) graphene oxide (GO) were added reinforcement materials. The structural changes, surface...
This research work is based on the synthesis of bis-Schiff base derivatives commercially available ibuprofen drug in outstanding yields through multistep reactions. Structures synthesized compounds were confirmed by help modern spectroscopic techniques including high-resolution electrospray ionization mass spectrometry (HR-ESI-MS), 1H NMR, and 13C NMR. The evaluated for their anticancer activity using a normal human embryonic kidney HEK293 cell U87-malignant glioma (ATCC-HTB-14) as cancer...
Background: Bacterial metabolites play a crucial role in human health and have proven effective treating various diseases. In this study, the 16S rRNA method streaking were employed to isolate molecularly identify bacterial strain, with goal of characterizing bioactive volatile extracted using nonpolar polar solvents. Methods: Gas chromatography-mass spectrometry (GC-MS) analysis was conducted 29 compounds metabolites, including key associated Bacillus spp. The main identified included...
Five organotin(IV) derivatives (1–5) of general formula R3SnL and R2SnL2, where R = C4H9 {1, 3}, CH3 {2 4}, C6H5 {5} L represents 4-fluorophenoxyacetate ligand were synthesized by the condensation reaction corresponding chloride sodium-4-fluorophenoxyaceate salt in dry chloroform under reflux condition. The elemental analysis has confirmed expected composition complexes. Δν values (less than 200 cm−1) calculated from FT-IR spectra revealed bridging/chelating bidentate coordination...
To predict immunogenic promiscuous T cell epitopes from the polyprotein of Zika virus using a range bioinformatics tools. date, no epitope data are available for in IEDB database.We retrieved nearly 54 full length sequences NCBI database belonging to different outbreaks. A consensus sequence was then used that bind MHC 1 and II alleles PorPred1 ProPred immunoinformatic algorithms respectively. The antigenicity predicted score also calculated each VaxiJen 2.0 tool.By ProPred1, 23 antigenic...
Four organotin(IV) carboxylate complexes; (C4H9)3SnL (1), CH3SnL (2), (C4H9)2SnL2 (3) and (CH3)2SnL2 (4) are synthesized by the condensation reaction of chlorides with sodium-4-chloro-2-methylphenoxyacetate (NaL). The FT-IR spectra suggested bridging/chelating bidentate coordination ligand to tin atom. Single-crystal XRD analysis authenticated findings for 1 2. NMR study has shown no significant differences in signals free coordinated except absence a proton up-filed/down-field shift C...
Human Papilloma Virus (HPV) is small DNA virus mostly infecting mucosa and cutaneous keratinocytes. So far, more than 200 papillomaviruses are known. HPV have been divided into high- low-risk on the basis of their oncogenic potential. High risk considered to be main etiological cause for cervical cancer.The current study was designed screen local cancer patients from twin cities Pakistan occurance high HPV.A total 67 formalin fixed paraffin-embedded samples biopsies were obtained government...
Imidazolidine and thiazolidine-based isatin derivatives (IST-01–04) were synthesized, characterized, tested for their interactions with ds-DNA. Theoretical experimental findings showed good compatibility indicated compound–DNA binding by mixed mode of interactions. The evaluated parameters, i.e., constant (Kb), free energy change (ΔG), site sizes (n), inferred comparatively greater more spontaneous IST-02 then IST-04 the DNA, among all compounds under physiological pH temperature (7.4, 37...
Temozolomide (TMZ), the first-line chemotherapeutic drug against glioblastoma multiforme (GBM), often fails to provide desired clinical outcomes due inflammation-induced resistance amid inefficient delivery across blood-brain barrier (BBB). The current study utilized solid lipid nanoparticles (SLNPs) for targeted of TMZ GBM. After successful formulation and characterization SLNPs conjugation with (SLNP-TMZ), their in-vitro anti-cancer efficacy effect on migratory potential cancer cells were...
Bis-acyl-thiourea derivatives, namely N,N'-(((4-nitro-1,2-phenylene)bis(azanediyl)) bis(carbonothioyl))bis(2,4-dichlorobenzamide) (UP-1), N,N'-(((4-nitro-1,2-phenylene) bis(azanediyl))bis(carbonothioyl))diheptanamide (UP-2), and N,N'-(((4-nitro-1,2-phenylene)bis(azanediyl))bis(carbonothioyl))dibutannamide (UP-3), were synthesized in two steps. The structural characterization of the derivatives was carried out by FTIR, 1H-NMR, 13C-NMR, then their DNA binding, anti-urease, anticancer...
Taxus wallichiana is an evergreen tree species found in the Himalayan region of Pakistan. The possesses important secondary metabolites such as Taxol that has been implicated treating breast, ovarian and colon cancer. Therefore keeping view importance this plant species, silver nanoparticles were synthesized using aqueous leaf extract evaluated for their anti-bacterial anti-cancer properties.Silver (Ag) (NPs) characterized optical, morphological structural features techniques UV-visible...