A5017616882- Synthesis and biological activity
- Synthesis and Characterization of Heterocyclic Compounds
- Enzyme function and inhibition
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Click Chemistry and Applications
- Computational Drug Discovery Methods
- Cholinesterase and Neurodegenerative Diseases
- Biochemical and Molecular Research
- Phenothiazines and Benzothiazines Synthesis and Activities
- Microbial Applications in Construction Materials
- Metal complexes synthesis and properties
- Alkaline Phosphatase Research Studies
- melanin and skin pigmentation
- Synthesis and Biological Evaluation
- Synthesis and Catalytic Reactions
- Crystal structures of chemical compounds
- Phytochemicals and Antioxidant Activities
- Sulfur-Based Synthesis Techniques
- Multicomponent Synthesis of Heterocycles
- Bioactive Compounds and Antitumor Agents
- Adenosine and Purinergic Signaling
- Structural and Chemical Analysis of Organic and Inorganic Compounds
- Quinazolinone synthesis and applications
- Crystallography and molecular interactions
Dawood University of Engineering and Technology
2022-2025
Quaid-i-Azam University
2014-2023
Shah Abdul Latif University
2022
University College of Islamabad
2020
National University of Sciences and Technology
2019
Ludwig-Maximilians-Universität München
2019
Wuhan University
2019
Pennsylvania State University
2019
Uppsala University
2019
University of Science and Technology of China
2019
Ferrocene derivatives constitute an important class of organometallic compounds with not only extensive range biological activities but also diverse industrial as well material science applications. These stimulating features ferrocene spurred us to review the recent advances in synthesis methods and other applications reported latest literature. An effort has been made summarize developments synthetic providing access scaffolds useful medicinal applications, including agricultural,...
Porcine Pancreatic Elastase (PPE) is a serine protease that homologous to trypsin and chymotrypsin are involved in various pathologies like inflammatory disease, Chronic Obstructive Pulmonary Disease (COPD), acute respiratory distress syndrome, cystic fibrosis, atherosclerosis. PPE if remained uninhibited would lead digestion of important connective tissue. We developed new structurally diverse series adamantyl-iminothiazolidinone hybrids divulge elastase inhibition assay. To identify potent...
Abstract Mild steel (MS) corrosion is a worldwide issue that greatly affects the industrial and natural environment. To extend lifespan of appliances, control MS necessary. shield from corrosion, specifically acidic conditions, one practical finest approaches application inhibitors. Triazole derivatives are eco-friendly inhibitors (CIs) having inconsequential toxicities, excellent inhibition efficiencies (IEs) against MS, extremely high cost-effectiveness. This critical review discusses...
A series of symmetrical salicylaldehyde-bishydrazine azo molecules, 5a-5h, have been synthesized, characterized by 1H-NMR and 13C-NMR, evaluated for their in vitro α-glucosidase α-amylase inhibitory activities. All the synthesized compounds efficiently inhibited both enzymes. Compound 5g was most potent derivative series, powerfully α-amylase. The IC50 against 0.35917 ± 0.0189 µM (standard acarbose = 6.109 0.329 µM), value 0.4379 0.0423 33.178 2.392 µM). Lineweaver-Burk plot indicated that...
Sulfonamide derivatives serve as an important building blocks in the drug design discovery and development (4D) process. Ciprofloxacin-, sulfadiazine- amantadine-based sulfonamides were synthesized potent inhibitors of jack bean urease free radical scavengers. Molecular diversity was explored electronic factors also examined. All 24 compounds exhibited excellent potential against enzyme. Compound 3e (IC50 = 0.081 ± 0.003 µM), 6a 0.0022 0.0002 9e 0.0250 0.0007 µM) 12d 0.0266 0.0021 found to...
Abstract In the current study, Azo-Thiohydantoins derivatives were synthesized and characterized by using various spectroscopic techniques including FTIR, 1 H-NMR, 13 C-NMR, elemental HRMS analysis. The compounds evaluated for alkaline phosphatase activity it was observed that among all compounds, derivative 7e exhibited substantial inhibitory (IC 50 = 0.308 ± 0.065 µM), surpassing standard inhibitor (L–Phenyl alanine, IC 80.2 1.1 µM). Along with this, these comprehensively examined...
The current research article reports the synthesis of coumarinyl pyrazolinyl thioamide derivatives and their biological activity as inhibitors jack bean urease. thioamides were synthesized by reacting thiosemicarbazide with newly chalcones to afford products in good yields compounds purified recrystallization. Coumarinyl 5a – 5q showed significant against Urease enzyme also exhibited antioxidant potential. compound 3‐(2‐oxo‐2 H ‐chromen‐3‐yl)‐5‐phenyl‐4,5‐dihydro‐1 ‐pyrazole‐1‐carbothioamide...
Antimicrobial resistance (AMR) compelled scientists in general while pharmacists, chemists and biologists specific to believe that we could always remain ahead of the pathogens. The pipeline new drugs is running gasping inducements develop antimicrobials address global problems drug are weak. In this pursuit, effective endeavours prepare anti-bacterial entities highly wished. present study demonstrates successful synthesis a library 1,4-disbustituted 1,2,3-triazoles (3a-3k) using...
Imidazolidine and thiazolidine-based isatin derivatives (IST-01–04) were synthesized, characterized, tested for their interactions with ds-DNA. Theoretical experimental findings showed good compatibility indicated compound–DNA binding by mixed mode of interactions. The evaluated parameters, i.e., constant (Kb), free energy change (ΔG), site sizes (n), inferred comparatively greater more spontaneous IST-02 then IST-04 the DNA, among all compounds under physiological pH temperature (7.4, 37...
Bis-acyl-thiourea derivatives, namely N,N'-(((4-nitro-1,2-phenylene)bis(azanediyl)) bis(carbonothioyl))bis(2,4-dichlorobenzamide) (UP-1), N,N'-(((4-nitro-1,2-phenylene) bis(azanediyl))bis(carbonothioyl))diheptanamide (UP-2), and N,N'-(((4-nitro-1,2-phenylene)bis(azanediyl))bis(carbonothioyl))dibutannamide (UP-3), were synthesized in two steps. The structural characterization of the derivatives was carried out by FTIR, 1H-NMR, 13C-NMR, then their DNA binding, anti-urease, anticancer...
Abstract A sequence of new 5‐aryl/heteroaryl‐2,2‐dimethyl‐1,3‐dioxane‐4,6‐dione derivatives were synthesized by condensing Meldrum's acid and triethyl orthoformate with differently substituted aromatic heteroaromatic amines in good to excellent yields. The chemical structures characterized spectroscopic techniques the entities evaluated for chymotrypsin urease inhibition. Interestingly, among derivatives, compound containing 5‐nitropyridin‐2‐yl ring exhibited dual inhibition activities IC 50...