A5051570658- Melanoma and MAPK Pathways
- CAR-T cell therapy research
- Cancer Immunotherapy and Biomarkers
- Cancer Cells and Metastasis
- Immunotherapy and Immune Responses
- Cancer Genomics and Diagnostics
- Single-cell and spatial transcriptomics
- Estrogen and related hormone effects
- T-cell and B-cell Immunology
- Neuroscience and Neuropharmacology Research
- Click Chemistry and Applications
- Chemokine receptors and signaling
- Epigenetics and DNA Methylation
- Breast Cancer Treatment Studies
- Nanoplatforms for cancer theranostics
- Photoreceptor and optogenetics research
- Retinal Development and Disorders
- Cutaneous Melanoma Detection and Management
- Cancer-related Molecular Pathways
- PI3K/AKT/mTOR signaling in cancer
- Microtubule and mitosis dynamics
Dartmouth College
2018-2024
Middlebury College
2022
Nanyang Technological University
2017
Regulatory T cells (Treg) are critical mediators of immunosuppression in established tumors, although little is known about their role restraining immunosurveillance during tumorigenesis. Here, we employ an inducible autochthonous model melanoma to investigate the earliest Treg and CD8 effector T-cell responses oncogene-driven Induction oncogenic BRAFV600E loss Pten melanocytes led localized accumulation FoxP3+ Tregs, but not cells, within 1 week detectable increases melanocyte...
Stratifying breast cancer into specific molecular or histologic subtypes aids in therapeutic decision-making and predicting outcomes; however, these may not be as distinct previously thought. Patients with luminal-like, estrogen receptor (ER)-expressing tumors have better prognosis than patients more aggressive, triple-negative basal-like tumors. There is, a subset of luminal-like that express lower levels ER, which exhibit features. We found expressing traditionally considered to represent...
Targeted therapies have improved outcomes for certain cancer subtypes, but cytotoxic chemotherapy remains a mainstay triple-negative breast (TNBC). The epithelial-to-mesenchymal transition (EMT) is developmental program co-opted by cells that promotes metastasis and chemoresistance. There are no therapeutic strategies specifically targeting mesenchymal-like cells. We report the US Food Drug Administration (FDA)-approved chemotherapeutic eribulin induces ZEB1-SWI/SNF-directed chromatin...
Optical silencing of activity provides a way to test the necessity neurons in behaviour. Two light-gated anion channels, GtACR1 and GtACR2, have recently been shown potently inhibit cultured mammalian Drosophila. Here, we usefulness these channels larval zebrafish, using spontaneous coiling behaviour as assay. When GtACRs were expressed spinal embryonic zebrafish actuated with blue or green light, movement was inhibited. In GtACR1-expressing fish, only 3 μW/mm2 light sufficient an effect;...
Abstract The epithelial-mesenchymal transition (EMT) is a developmental program co-opted by tumor cells that aids the initiation of metastatic cascade. Tumor undergo EMT are relatively chemoresistant, and there currently no therapeutic avenues specifically targeting have acquired mesenchymal traits. We show treatment mesenchymal-like triple-negative breast cancer (TNBC) with microtubule-destabilizing chemotherapeutic eribulin, which FDA-approved for advanced cancer, leads to...
Abstract In behavioral analysis, optical electrical silencing provides a way to test neuronal necessity. Two light-gated anion channels, GtACR1 and GtACR2, have recently been shown—in culture in Drosophila —to inhibit neurons potently. Here, we the usefulness of these channels zebrafish. When GtACRs were expressed motor actuated with blue or green light, fish spontaneous movement was inhibited. GtACR1-expressing fish, only 3 µW/mm 2 light sufficient an effect; which is poorly trafficked,...
Summary Differentiation therapy is an approach that utilizes our understanding of the hierarchy cellular systems to pharmacologically induce a shift towards terminal commitment. While this has been paradigm in treating certain hematological malignancies, efforts translate success solid tumors have proven challenging. In study we show activation PKA drives aberrant mammary differentiation by diminishing self-renewing potential basal compartment. results are more benign, exhibiting reduced...
Abstract/summary Stratifying breast cancer into specific molecular or histological subtypes aids in therapeutic decision-making and predicting outcomes, however, these may not be as distinct previously thought. Patients with luminal-like, Estrogen Receptor (ER)- expressing tumors have better prognosis than patients more aggressive, triple- negative basal-like tumors. There is, a subset of luminal-like that express lower levels ER, which exhibit features. We found traditionally considered to...
<p>Tregs expand in tumor draining lymph nodes</p>
<p>Chemokine protein levels and effects of neutralization</p>
<p>Treg accumulation kinetics in induced Braf/Pten skin grafts</p>
<p>Input population of tumor-experience Tregs; and effects pertussis toxin treatment</p>
<p>Histologic and molecular analysis of nevus-induced skin</p>
<p>Supplementary Materials and Methods</p>
<p>Tumor Ag-specific Tregs expand in draining lymph nodes</p>
<p>Supplementary Materials and Methods</p>
<p>Histologic and molecular analysis of nevus-induced skin</p>
<p>Input population of tumor-experience Tregs; and effects pertussis toxin treatment</p>
<p>Treg accumulation kinetics in induced Braf/Pten skin grafts</p>
<p>Chemokine protein levels and effects of neutralization</p>
<p>Tregs expand in tumor draining lymph nodes</p>
<p>Tumor Ag-specific Tregs expand in draining lymph nodes</p>
<div>Abstract<p>Regulatory T cells (Treg) are critical mediators of immunosuppression in established tumors, although little is known about their role restraining immunosurveillance during tumorigenesis. Here, we employ an inducible autochthonous model melanoma to investigate the earliest Treg and CD8 effector T-cell responses oncogene-driven Induction oncogenic BRAF<sup>V600E</sup> loss Pten melanocytes led localized accumulation FoxP3<sup>+</sup> Tregs,...
<div>Abstract<p>Regulatory T cells (Treg) are critical mediators of immunosuppression in established tumors, although little is known about their role restraining immunosurveillance during tumorigenesis. Here, we employ an inducible autochthonous model melanoma to investigate the earliest Treg and CD8 effector T-cell responses oncogene-driven Induction oncogenic BRAF<sup>V600E</sup> loss Pten melanocytes led localized accumulation FoxP3<sup>+</sup> Tregs,...