A5027237108- Child and Adolescent Psychosocial and Emotional Development
- Attachment and Relationship Dynamics
- Maternal Mental Health During Pregnancy and Postpartum
- Family Dynamics and Relationships
- Infant Development and Preterm Care
- Family Support in Illness
- Diabetes Management and Education
- Lung Cancer Treatments and Mutations
- Family and Disability Support Research
- Diabetes Treatment and Management
- Chronic Kidney Disease and Diabetes
- Early Childhood Education and Development
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Glutathione Transferases and Polymorphisms
- Blood Pressure and Hypertension Studies
- Intimate Partner and Family Violence
- Case Reports on Hematomas
- Dialysis and Renal Disease Management
- Cardiac electrophysiology and arrhythmias
- Food Security and Health in Diverse Populations
- Renal Diseases and Glomerulopathies
- Child Therapy and Development
- Histone Deacetylase Inhibitors Research
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Peptidase Inhibition and Analysis
National Cancer Centre Singapore
2024-2025
Royal Children's Hospital
2017-2023
Murdoch Children's Research Institute
2017-2023
Clinical Nutrition Research Centre
2022-2023
Deakin University
2017-2023
National University of Singapore
2023
La Trobe University
2020
Rotherham General Hospital
2007-2012
Radiotherapy is the primary treatment modality for most head and neck cancers (HNCs). Despite addition of chemotherapy to radiotherapy enhance its tumoricidal effects, almost a third HNC patients suffer from locoregional relapses. Salvage therapy options such recurrences are limited often suboptimal, partly owing divergent tumor microenvironmental factors underpinning radioresistance. In this study, we utilized combinatorial functionomics approach, Quadratic Phenotypic Optimization Platform...
Attachment status in early childhood is a key yet modifiable contributor to the development of social–emotional competence. The security and organization infant–mother attachment bond particularly susceptible stressors caregiving environment. While impacts normative interparental conflict on infant are increasingly understood, potentially unique place intimate partner violence (IPV) this pathway has been under-researched. This study surveyed all empirical work area, including unpublished...
Background Here, we report new prevalence and temporal stability data for child attachment parental caregiving behaviour, from infancy (1 year) to preschool (4 years). Methods Attachment (SSP) (MBQS) were observations of parents their infants preschoolers, who represent the third generation participants within an Australian longitudinal cohort. Results At 1 year ( n = 314 dyads) at 4 years 368 dyads), proportions assessed secure 59% 71%, respectively. Proportions avoidant 15% 11%; ambivalent...
This article reports on a cluster randomized pilot study of mediation‐based intervention for separated parents very young children, Young Children in Divorce and Separation (YCIDS). The control group was “Mediation plus Reading.” Participants were attending mediation over co‐parenting dispute concerning child under the age 5 years ( n =33 cases). Nine 16 key parent outcomes significantly better group, with remainder nonsignificant between groups. Mediators reported 35 per cent lower referral...
Conflicted parental separation is associated with escalating risks to wellbeing and safety for all family members. The Family Law DOORS (FL-DOORS, Detection Of Overall Risk Screen) a three-part framework designed assist frontline workers identify, evaluate, respond these in separated families. FL-DOORS system includes 10-domain parent self-report screening measure, covering child wellbeing, cultural social risks, experienced by initiated each parent. A first validation study of this screen...
In providing the best care for patients, health providers (HCPs) rely on clinical experience and judgment, published literature, evidence-based guidelines to direct decisions serve as benchmarks achieving optimal patient outcomes. Several are available support HCPs in caring patients with type 2 diabetes. These include recommendations from American Diabetes Association (ADA),1 World Health Organization (WHO),2 of Clinical Endocrinologists (AACE),3 Indian Service (IHS),4 Center Medicaid...
To study the natural history and predictors of faster glomerular filtration rate (GFR) decline in a referred population older patients (aged ≥ 65 years) with type 2 diabetes mellitus.A retrospective medical record analysis an outpatient clinic for patients. Baseline characteristics blood pressure readings each visit were recorded. All laboratory results downloaded from central database pathology laboratory. Annual GFR was calculated by linear regression as slope per year individual. Patients...
137 Background: Resistance to RT remains a clinical challenge, given our limited understanding of the molecular pathways underpinning radioresistance. Here, we investigated for mechanisms linked RR using paired experimental and clinico-molecular HNC PCa datasets discovery validation novel that may be enriched in cancers. Methods: For data, generated (FaDu, HK1) (22Rv1, DU145) cell lines following high-dose X-irradiation (90 Gy 45 fr). Genotypic characterization wildtype (WT) cells was...
Abstract Radiotherapy is an integral modality in treating human cancers, but radioresistance remains a clinical challenge due to the involvement of multiple intrinsic cellular and extrinsic tumour microenvironment factors that govern radiosensitivity. To study are associated with cancer radioresistance, we established 4 radioresistant prostate (22Rv1 DU145) head neck (FaDu HK1) models by irradiating their wild-type parentals 90 Gy, mimicking fractionated radiotherapy schema often using...
Abstract Chronic insecurities that emerge from adverse experiences in early intimate partner relationships adolescence and emerging adulthood can have profound impacts on mental health well‐being. Less clear is the extent to which these for parents impact subsequent within across generations. We examine secure, dismissing, pre‐occupied, fearful adulthood, well before becoming a parent, are associated with next‐generation patterns of attachment between mothers infant offspring. Data were...
A 77 year old man presented to A&E with sudden onset left sided chest pain. This pain was severe enough wake him up from sleep in the early hours of morning. The pleuritic nature and require administration intravenous morphine. He had a past medical history ischaemic heart disease (1997), pulmonary embolism pnuemothorax (1998). Drug consisted lansoprazole 30mg od, isosorbide mononitrate 60mg nicorandil 10mg bd, aspirin 75mg beclomethasone 100 inhaler 1 puff salbutamol prn combivent...
Abstract Despite ongoing reforms to child protection systems and calls for a greater focus on prevention early intervention, demand statutory services continues grow across developed countries. The reasons this are multiple complex include: (1) barriers that exist within service themselves; (2) the entrenched interwoven nature of drivers maltreatment (3) limited access programs can be implemented at scale. This means empirically supported interventions address not widely available support...
Objective: We aimed to develop and validate Australian guidelines support accurate assessment of preschool attachment by researchers child clinical psychologists allied pracitioners. Method: The Preschool Attachment Scales (APAS) were developed through grounded item generation validated with data from 121 parent dyads, for whom we compared codes assigned certified naïve coders. Results: APAS scores reliable coders highly correlated (r = 0.52 - 0.79). Accuracy organised classifications using...
Providing high-quality early childhood care and education is understood as key to maximizing children's potential succeed later in life, it stimulates young development of skills competencies needed promote optimal outcomes success life. Despite the government's efforts support sector, educators Singapore continue report difficulties implementing practices classrooms that social, emotional, cognitive development. To enhance educators' these domains, we developed Enhancing And Supporting...
Abstract Background Providing high-quality early childhood care and education is widely understood as key to maximizing children's potential succeed later in life, it equips young children with the essential skills competencies needed for their development. Despite government's efforts support sector, educators Singapore continue report difficulties implementing practices classrooms that promote social, emotional, cognitive To enhance educators' these domains, we developed Enhancing...