A5077171516- Gastric Cancer Management and Outcomes
- Colorectal Cancer Screening and Detection
- Gastroesophageal reflux and treatments
- Eosinophilic Esophagitis
- Gastrointestinal Bleeding Diagnosis and Treatment
- Gastrointestinal Tumor Research and Treatment
- Uterine Myomas and Treatments
- Endometriosis Research and Treatment
- Esophageal and GI Pathology
- Gastrointestinal disorders and treatments
- Metastasis and carcinoma case studies
- Mycobacterium research and diagnosis
- Helicobacter pylori-related gastroenterology studies
- Celiac Disease Research and Management
- Eosinophilic Disorders and Syndromes
- Endometrial and Cervical Cancer Treatments
- Inflammatory Bowel Disease
- Gynecological conditions and treatments
- Healthcare innovation and challenges
- Microscopic Colitis
- Cardiac Valve Diseases and Treatments
- Dysphagia Assessment and Management
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Amoebic Infections and Treatments
- Genetic and Kidney Cyst Diseases
University Hospitals of Leicester NHS Trust
2010-2022
NIHR Clinical Research Network
2018
University of Leicester
2014-2015
Women's General Hospital
2011-2014
Johannes Kepler University of Linz
2014
Leicester Royal Infirmary
2000-2013
Providence College
2011
Hannover Re (Germany)
2011
National Health Service
2005
Leicester General Hospital
2000
Background Endoscopy within 24 h of admission (early endoscopy) is a quality standard in acute upper gastrointestinal bleeding (AUGIB). We aimed to audit time endoscopy outcomes and identify factors affecting delayed (>24 admission). Methods This prospective multicentre enrolled patients admitted with AUGIB who underwent inpatient between November December 2017. Analyses were performed associated endoscopy, compare patient outcomes, including length stay mortality rates, early groups....
Objective . To evaluate patients’ health status and the course of endometriosis from premenopausal to postmenopausal period influencing factors that may be relevant. Methods Questionnaire completed by 35 women in whom had been histologically confirmed premenopausally. Correlation regression analyses were carried out identify relevant their status. Results Overall, there was clear improvement typical symptoms sexual life. Clear associations (<mml:math...
Gastro-oesophageal reflux (GER) and coronary artery disease commonly co-exist. Coronary patients may mistake GER-induced pain for cardiac or GER might provoke angina.To investigate if contribute to nocturnal/rest chest among patients.Double-blind placebo-controlled crossover study investigating effect of lansoprazole on pain; 125 with angiographically proven enrolled at least one weekly episode pain, randomized 30 mg daily placebo after 4 weeks. Symptoms recorded QOL assessed by Nottingham...
Pyogenic liver abscess (PLA) is a rare extraintestinal complication of Crohn's disease (CD), and the clinical laboratory findings may emulate reactivation CD, therefore, delaying diagnosis. In this paper patient presented with PLA as initial manifestation CD experienced severe disease. The finding was established by computed tomography treatment involved percutaneous drainage antibiotics. diagnosis made after colonoscopy histological investigations.
Objective Colonoscopy is the ‘gold standard’ assessment for large bowel mucosal pathology, but a complete examination essential. The first national colonoscopy audit carried out in 1999 demonstrated caecal intubation rates (CIRs) of 56.9%. As result, Joint Advisory Group (JAG) on gastrointestinal endoscopy launched programme continuous quality improvement. JAG recommends that practitioners undertake 100+ procedures per annum with target CIR 90%. This current provides an performance against...
Idiopathic intestinal varicosis is a developmental disorder defined by dilated and convoluted submucosal veins in the colon or small bowel. A limited number of families with idiopathic varices has been reported, but genetic cause not yet identified. We performed whole-exome targeted Sanger sequencing candidate genes five families. In four families, mutations RPSA gene were found, previously linked to congenital asplenia. Individuals these pedigrees had varicose angiodysplasia, often...
Abstract Objective There is an increased risk of colorectal cancer in patients with inflammatory bowel disease (IBD). The aim this study was to compare the prevalence left sided adenomas IBD aged 55–64 years a local age matched control population. Method A review clinical notes. attending for either sigmoidoscopy or colonoscopy compared controls that participated national screening trial flexible sigmoidoscopy. Results Of 106 (61 male, 45 female, mean 59 years), 80 suffered from ulcerative...
Endoscopic mucosal resection is commonly the treatment regime of choice for large sessile colonic polyps. We describe computed tomography findings a 51 year old female who presented with transient severe abdominal pain without systemic upset post endoscopic polyp resection, which resolved conservative management. This second case in literature that demonstrates 'normal' appearances resection. The clinical team and radiologist need to be aware these when making management decisions patients...
Abstract Kikuchi’s disease is usually a self limiting illness characterised by pyrexia, neutropenia, and cervical lymphadenopathy particularly in young women of Asian descent. This often leads to an initial misdiagnosis lymphoma. A case woman who presented with pyrexia unknown origin described.
The British Society of Gastroenterology (BSG) Strategy document 'Care patients with Gastrointestinal (GI) disorders' recommends that all acute hospitals should have arrangements for out-of-hours (OOH) endoscopy staffed appropriately trained endoscopists. UK national audit published in 2010 found only 52% across the had a formal consultant-led OOH on-call rota. University Hospitals Leicester (UHL) established rota 2006, which now provides 24/7 cover. To define workload newly service, we...
<h3>Introduction</h3> The incidence of upper gastrointestinal bleeds is 50–150 cases per 100 000.<sup>1</sup> introduction the CROMES: “Scope for improvement” toolkit<sup>2</sup> has focused on need provision a comprehensive GI bleed service. RR-adjusted mortality in hospitals without an out hours rota 1.21 compared to those with rota.<sup>1</sup> Despite this only 52% have formal (OOH) endoscopy University Hospitals Leicester (UHL) established 2006 which now provides 24/7 cover. We examined...
<h3>Introduction</h3> Colonoscopy is the gold standard assessment for large bowel mucosal pathology, but a complete examination an essential requirement. The first national colonoscopy audit carried out in 1999 demonstrated caecal intubation rates (CIRs) of 56.9%, which authors described as "unacceptably low". As result Joint Advisory Group on Gastrointestinal endoscopy (JAG) launched programme continuous quality improvement by standardising training, peer review and audit. JAG recommends...
AIM: To assess the clinical outcome of a service providing colonic endoscopic mucosal resection (EMR) polyps ≥ 20 mm at University Hospital Leicester NHS Trust and to changes over 9-year period. METHODS: Retrospective observational study, data were prospectively collected for all cases sessile that removed via EMR by colonoscopists accredited Bowel Cancer Screening Programme (BCSP) between 2006 2014. RESULTS: 569 lesions in 564 patients assessed EMR; 424 successfully excised EMR....