A5101950520- Multiple Myeloma Research and Treatments
- Protein Degradation and Inhibitors
- Peptidase Inhibition and Analysis
- Antimicrobial Peptides and Activities
- Ubiquitin and proteasome pathways
- Hematopoietic Stem Cell Transplantation
- Immune Cell Function and Interaction
- Crystallization and Solubility Studies
- Chemical Synthesis and Reactions
- CAR-T cell therapy research
- Cancer Genomics and Diagnostics
- Autophagy in Disease and Therapy
- Gastrointestinal Tumor Research and Treatment
- Immunotherapy and Immune Responses
- Gastric Cancer Management and Outcomes
- Cancer Treatment and Pharmacology
- Gastrointestinal disorders and treatments
- Reproductive System and Pregnancy
- Chemokine receptors and signaling
- Aldose Reductase and Taurine
- Crystallography and molecular interactions
- Cancer Research and Treatments
- Proteoglycans and glycosaminoglycans research
- Platelet Disorders and Treatments
- Elbow and Forearm Trauma Treatment
Hengshui University
2025
The Fourth People's Hospital
2025
Jiangsu Province Hospital
2020-2024
Nanjing Medical University
2014-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2016-2024
Harbin Medical University
2024
First Affiliated Hospital of Harbin Medical University
2024
North China University of Science and Technology
2021
Peking Union Medical College Hospital
2021
Yuhuangding Hospital
2020
O'Driscoll type II fractures of the ulnar coronoid process present significant challenges in orthopedic surgery, requiring precise techniques for optimal recovery. To compare efficacy anterolateral approach versus medial treating elbow. This retrospective study involved 226 patients with treated at Fourth People's Hospital Hengshui between January 2021 and December 2023. Patients were divided into two groups according to surgical approach: lateral (n = 121) 105). Exclusion criteria included...
Sorafenib is the standard systemic treatment for advanced hepatocellular carcinoma (HCC), and improving its therapeutic effects crucial addressing cancer aggression.We previously reported that epalrestat, an aldo-keto reductase 1B10 inhibitor, enhanced sorafenib's inhibitory on HCC xenograft in nude mice.This study aimed to elucidate mechanism of epalrestat's anti-tumour enhancing sorafenib.HepG2 cells were treated with sorafenib, their combination.Cell proliferation was assessed Cell...
The T lymphocyte system plays an active role in tumor immunosurveillance multiple myeloma (MM), and abnormal populations are often observed patients with MM. In the current study, we evaluated prognostic impact of subset distributions newly diagnosed MM (NDMM). Between December 2012 to October 2016, 110 NDMM were included this study. Multiparameter flow cytometry was applied quantitatively analysis peripheral blood subsets, including CD4+ cell, CD8+ CD4/CD8 ratio. Survival analyses performed...
Objectives Multiple myeloma (MM) involves a clinically and biologically heterogeneous malignancy of plasma cells. It is difficult to predict the prognosis MM. The presence circulating clonal cells (CPC) has been associated with worse in patients MM.Methods This study retrospectively analysed CPC 108 newly diagnosed MM by 8-colour flow cytometry investigate their value for predicting outcome combined level revised International Staging System (R-ISS) stratify according risk.Results were...
Abstract The aim of the study was to evaluate prognostic impact minimal residual disease (MRD) in real-world setting and interaction between MRD molecular risk, clinical response autologous stem-cell transplant (ASCT). A retrospective analysis 275 newly diagnosed multiple myeloma (NDMM) patients who achieved very good partial remission (VGPR) or better before maintenance were involved. We examined status by multiparameter flow cytometry (MFC). At a median follow-up 37 months (4–88 months),...
Hepatocellular carcinoma (HCC) is the fifth most common and third deadliest primary neoplasm. Since HCC a particularly vascular solid tumor, we determined antitumor antiangiogenic activities of sunitinib malate, potent inhibitor two receptors involved in angiogenesis – endothelial growth factor receptor (VEGFR) plateletderived (PDGFR). In present study, reported that treatment HepG2 SK-Hep-1 cells with led to inhibition apoptosis dose-dependent fashion. Sunitinib inhibited phosphorylation...
Background: Extramedullary disease (EMD) is an unusual event in patients with MM. This study aimed to assess the prognostic impact of EMD and develop EMD-based risk model estimate survival newly diagnosed multiple myeloma (NDMM).
Introduction Circulating plasma cells (CPC) have been reported to be one of the indicators high-risk multiple myeloma (MM), yet prognostic significance CPC in Chinese population and genetic mechanisms underlying formation not fully elucidated. Methods Patients with newly diagnosed MM were included this study. We used multi-parameter flow cytometry (MFC) for quantification next-generation sequencing (NGS) technology mutational landscape mapping identify correlation level clinical...
Optimal preparation conditions of DNA vaccine against swine influenza encapsulated in Poly (D,L)-lactic-co-glycolic acid (PLGA) microspheres were determined. The prepared by an emulsion-evaporation method using PLGA as the biodegradable matrix forming polymer. Using optimal conditions, containing produced with good morphology evident from scanning electron micrographs, high encapsulation rate and stability. transfection test indicated that could be expressed antigen cells maintained...
The aim of our study was to determine the impact CD200 expression in newly diagnosed myltiple myeloma (MM) patients. CD200+ patients had significantly shorter median overall survival time (OS) than CD200– (41.0 months vs. not reached, p = .009). ratio CD4+ CD8+ T cells lower and this reduction related increase (p .021). Moreover, we analyzed dynamic changes 47 during treatment. Thirty-eight (80.9%) switched Those a favorable compared with others (median OS, 65.0 32.0 months, < .001; PFS,...
The engineered human cystathionine-γ-lyase (hCGL) resulting in enhanced activity toward both cysteine and cystine unveils a potential robust antitumor activity. However, the presence of residues has to induce oligomerization or incorrect disulfide bonding, which may decrease bioavailability biopharmaceuticals. Through meticulous design process targeting within hCGL, set beneficial mutants were obtained by virtual screening employing Rosetta ABACUS. Experimental measurements have revealed...
Abstract Background With the rapid development of next-generation sequencing (NGS) technologies, researchers are making efforts to reveal genomic landscape multiple myeloma (MM). However, clinical significance many mutations remains poorly defined due genetic heterogeneity MM. To systematically explore implications gene and build practical prognostic models, we performed DNA in newly diagnosed MM patients. Methods cells were purified from bone marrow aspirates using CD138 microbeads...
The prevalence of hepatitis B virus (HBV) infection was an imbalance in different provinces China. This study aimed to investigate the HBV and evaluate prophylactic measures a public hospital northeast China over preceding 13 years. A total 13,948 patients 2004 15,256 2017 Shengjing Hospital Medical University were tested serum HBsAg, HBeAg, HBsAb, HBeAb, HBcAb levels with Abbott MEIA Kits. In people born before 1992, HBsAg-positive rate 5.45% 6.47%; isolated HBsAb positive 14.62% 21.24%;...
Abstract An anticancer bioactive peptide (ACBP), goat peroxiredoxin-5 (gPRDX5), was identified from goat-spleen extract after immunizing the with gastric cancer-cell lysate. Its amino acid sequence determined by employing 2D nano-LC-ESI-LTQ-Orbitrap MS/MS combined Mascot database search in subset of Uniprot database. The recombinant gPRDX5 protein acquired heterogeneous expression Escherichia coli. Subsequently, anti-cancer bioactivity measured several kinds tumor cells. results indicated...
The solid-state properties of 2-[(2,6-dichlorophenyl)amino]-benzaldehyde (DCABA) were investigated. Unlike its precursor diclofenac acid, for which three polymorphs are currently known, only one crystalline form DCABA was found. It further characterized by other spectroscopic and spectrometric methods including IR, Raman, UV–vis spectroscopy powder X-ray diffraction (PXRD). thermal behavior the studied differential scanning calorimetry (DSC). Theoretical studies, Hirshfeld surface analysis...
Abstract Rationale: Nasopharyngeal carcinoma (NPC) is one of the most common malignancies in Southern China. Although combined chemotherapy with radiotherapy has been widely used treating locally advanced lesions, relapse and metastases remain primary cause treatment failure, are associated an extremely poor prognosis. Therefore, more efficient milder therapies needed. Patient concerns: Herein, we report a patient NPC intracranial who showed progression during conventional treatment....
To investigate the characteristics of cytopenia and its impact on prognosis in patients with relapsed refractory multiple myeloma (RRMM) after B-cell maturation antigen (BCMA) chimeric receptor T-cell (CAR-T) immunotherapy therapy.
To investigate the therapeutic effect and prognostic value of oligoclonal bands (OB) in multiple myeloma (MM) patients after autologous stem cell transplant (ASCT).