A5037219613- RNA modifications and cancer
- Epigenetics and DNA Methylation
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Genetic factors in colorectal cancer
- Acute Myeloid Leukemia Research
- Cancer Genomics and Diagnostics
- Cardiac Valve Diseases and Treatments
- Liver Disease Diagnosis and Treatment
- Aortic Disease and Treatment Approaches
- Erythrocyte Function and Pathophysiology
- BRCA gene mutations in cancer
- RNA Research and Splicing
- Cancer-related gene regulation
- Hepatitis B Virus Studies
- Infective Endocarditis Diagnosis and Management
- Immune Cell Function and Interaction
- Pancreatic and Hepatic Oncology Research
- Coronary Artery Anomalies
- Hemophilia Treatment and Research
- Genetic Associations and Epidemiology
- Effects and risks of endocrine disrupting chemicals
- Thyroid Cancer Diagnosis and Treatment
- Blood properties and coagulation
- Chronic Myeloid Leukemia Treatments
Nanjing Brain Hospital
2025
Nanjing University
2025
Nanjing Medical University
2023-2025
Sichuan Agricultural University
2025
Huazhong University of Science and Technology
2015-2024
Tongji Hospital
2016-2024
Lanzhou University
2022-2024
First Affiliated Hospital of Zhengzhou University
2021-2024
Anhui Medical University
2024
Union Hospital
2012-2024
The individual effects of early-life tobacco smoke exposure and its interactions with genetic factors on lung cancer in adulthood remain unclear.
Abstract Aberrant expression of XIST, a long noncoding RNA (lncRNA) initiating X chromosome inactivation (XCI) in early embryogenesis, is common feature breast cancer (BC). However, the roles post-XCI XIST carcinogenesis remain elusive. Here we identify as key regulator stem cells (CSCs), which exhibit aldehyde dehydrogenase positive (ALDH + ) epithelial- (E) and CD24 lo CD44 hi mesenchymal-like (M) phenotypes. variably expressed across spectrum BC subtypes, doxycycline (DOX)-inducible...
Abstract Background Synaptic degeneration occurs in the early stage of Alzheimer's disease (AD) before devastating symptoms, strongly correlated with cognitive decline. Circular RNAs (circRNAs) are abundantly enriched neural tissues, and aberrant expression circRNAs precedes AD significantly clinical dementia severity. However, direct relationship between circRNA dysregulation synaptic impairment remains poorly understood. Methods Hippocampal whole-transcriptome sequencing was performed to...
Abstract Genome-wide association studies (GWAS) of colorectal cancer have identified several common susceptible variants in gene regulatory regions. However, low-frequency or rare coding risk not been systematically investigated patients with from Chinese populations. In this study, we performed an exome-wide analysis 1,062 and 2,184 controls a population. Promising associations were further replicated two replication sets: stage I 2,478 cases 3,880 controls, II 3,761 4,058 controls. We...
Designing covalent organic frameworks (COFs) with predetermined structures for uranium capture is vital energy and the environment, but it remains challenging complex COFs, which are expected to produce various structures, due lacking quantum-mechanics-based design principles. Here, we report COFs' principles based on intramolecular interactions precisely control their properties, toward high-performance sorbents. We investigate structure-directing effect of in hydroxyl-group-functionalized...
Riverine wetland is one of the important cityscapes along rivers, featuring powerful eco-hydrological regulations in safeguarding urban security and serving its quality. Over past several decades, intensified climate change, together with upgraded human activities, have deeply disturbed riverine worldwide caused variations amount pattern, which might lead to negative effects on ecosystem health (WEH), thus threaten sustainability agglomerations. To better understand mechanism above...
Simmental cattle are renowned for their dual purpose as meat and dairy breeds. The study recorded phenotype data from 183 performed a Genome-Wide Association Study (GWAS) analysis to elucidate the genetic mechanisms underlying milk production, body size traits, tail characteristics. Statistical of showed that season, parity, age at first calving (AFC) factors had significant effect on production (P < 0.05). results GWAS linear traits revealed candidate genes SH3RF2, DCHS2, ADAMTS1, CAMK4,...
Bipolar disorder (BD) and unipolar depression (UD) are defined as distinct diagnostic categories. However, due to some common clinical pathophysiological features, it is a challenge distinguish them, especially in the early stages of BD. This study aimed explore disease-specific connectivity patterns BD UD. was constructed over 181 BD, 265 UD 204 healthy controls. In addition, an independent group 90 patients initially diagnosed with major depressive at baseline then transferred episodes...
Several particular kinds of typical morphology characteristics leukemic blasts associated with the specific subtypes leukemia have been reported. However, B acute lymphoblastic leukemia/lymphoma (B-ALL/LBL) has rarely The purpose this study was to investigate correlation TCF3::PBX1 fusion multiple clefts nuclei in patients B-ALL/LBL. We retrospectively reviewed peripheral blood (PB) and bone marrow (BM) smears 145 prepared at time initial diagnosis B-ALL/LBL based on results testing for...
Resistance to the proteasome inhibitor bortezomib (BTZ) poses a formidable therapeutic challenge in multiple myeloma (MM). Our study aims analyze mechanism by which exosomes heat shock 70 kDa protein 9 (HSPA9) secreted BTZ-resistant MM cells disseminate resistance BTZ-sensitive cells. The serum were identified nanoparticle tracking analysis and transmission electron microscopy. Liquid chromatography-mass spectrometry public databases performed screen HSPA9. Cell counting kit-8, western...
Abstract Recent genome‐wide association studies (GWAS) have reported multiple genetic variations at 5p15.33 ( TERT‐CLPTM1L ) associated with risk of lung cancer. However, most the identified by GWAS thus far are unlikely to be actual causal variants, but may mostly marker‐single nucleotide polymorphisms tagging functional that influence gene expression. This study aimed explore function‐validated and potentially in locus conferring susceptibility A case–control including 502 cases controls...
BACKGROUND. The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a novel viral pneumonia (COVID-19), which is rapidly spreading throughout the world. positive result of nucleic acid test golden criterion to confirm SARS-CoV-2 infection, but detection features remain unclear.
Pancreatic cancer (PC) is an aggressive malignancy with extremely low 5-year survival rate (<5%). SWItch/Sucrose Non Fermentable (SWI/SNF) complex a core factor for chromatin-remodeling that utilize energy of ATP hydrolysis to mobilize nucleosomes, and modulate gene transcription. Recent studies have identified recurrent mutations in major components SWI/SNF variety human cancers, including PC. We conducted two-stage case–control study investigate the associations between 14 common variants...