A5076071143- Liver Disease Diagnosis and Treatment
- Liver Disease and Transplantation
- Alcohol Consumption and Health Effects
- COVID-19 Clinical Research Studies
- Liver Diseases and Immunity
- Hepatitis C virus research
- Esophageal and GI Pathology
- Clinical Nutrition and Gastroenterology
- SARS-CoV-2 and COVID-19 Research
- Long-Term Effects of COVID-19
- Pediatric Hepatobiliary Diseases and Treatments
- Gallbladder and Bile Duct Disorders
- Renal Transplantation Outcomes and Treatments
- Hepatitis B Virus Studies
- Intensive Care Unit Cognitive Disorders
- Organ Transplantation Techniques and Outcomes
- Venous Thromboembolism Diagnosis and Management
- Gastric Cancer Management and Outcomes
- Abdominal vascular conditions and treatments
- Neurological Complications and Syndromes
- Airway Management and Intubation Techniques
- Chemokine receptors and signaling
- Pancreatic and Hepatic Oncology Research
- Pneumocystis jirovecii pneumonia detection and treatment
- Gastrointestinal Bleeding Diagnosis and Treatment
Russells Hall Hospital
2008-2023
Dudley Group NHS Foundation Trust
2013-2022
British Athletics
2022
British Cycling
2022
Oxford University Clinical Research Unit Indonesia
2021
Nepal Health Research Council
2021
NIHR Clinical Research Network
2021
National Institute for Health Research
2021
National Records of Scotland
2021
Intensive Care National Audit & Research Centre
2021
Liver transplant recipients are at risk of chronic renal disease, principally as a result nephrotoxicity the commonly used immunosuppressive agents cyclosporine and tacrolimus. We have investigated incidence failure its factors in our population, which was treated predominantly with cyclosporine.A single-center retrospective study done 883 consecutive adult patients receiving first liver between 1982 1996. Potential for development were recorded, including serial measurements therapy...
<h3>Introduction:</h3> There is no consensus on the pharmacological treatment of alcoholic hepatitis. The Glasgow hepatitis score (GAHS) has been shown to be more accurate than modified Maddrey's discriminant function (mDF) in prediction outcome from This study aimed determine whether GAHS was able identify those patients who would benefit corticosteroids. <h3>Methods:</h3> 225 with an mDF greater or equal 32 five hospital centres United Kingdom were reviewed. Patient survival relative and...
Alcoholic liver disease is associated with three histologically distinct processes: steatosis (parenchymal fat accumulation), alcoholic hepatitis (characterized by parenchymal infiltration neutrophil polymorphs), and cirrhosis (in which chronic inflammation fibrosis dominate). Chemokines are cytokines that promote subset-specific leukoycte recruitment to tissues could therefore play a crucial role in determining leukocyte subsets recruited the disease. This paper reports chemokine expression...
BACKGROUND: Virus inactivation of pooled fresh‐frozen plasma (FFP) by the solvent/detergent (SD) method results in a loss approximately 20 percent factor VIII. This study aimed to assess efficacy SD‐treated correcting coagulopathy associated with liver disease and transplantation. STUDY DESIGN AND METHODS: Forty‐nine patients coagulation deficits due disease, who required FFP for invasive procedures or transplantation, were randomly assigned receive either plasma. Patients assessed side...
Hereditary deficiencies of natural anticoagulant proteins are implicated in the pathogenesis portal vein thrombosis (PVT). Secondary these have also been reported PVT, making interpretation concentrations difficult.To characterise coagulation profiles adult patients with PVT and to investigate possible mechanisms protein deficiency.Twenty nine hypertension caused by normal biochemical liver function tests.Routine C, S, antithrombin were measured; where indicated, corresponding parents...
BACKGROUND Alcoholic liver disease is associated with increased hepatic expression of monocyte chemoattractant protein 1 (MCP-1) and macrophage inflammatory 1α (MIP-1α). AIMS To determine whether concentrations chemokines in the peripheral circulation reflect activity, chemokine secretion restricted to or part a systemic response alcoholic disease. PATIENTS Fifty one patients 12 healthy controls. METHODS Peripheral vein (and undergoing transjugular biopsy) were measured by ELISA. Chemokine...
Lymphocyte recruitment to tissue is regulated by homing molecules expressed on subsets of leukocytes that bind endothelial adhesion termed addressins in target tissues. The and involved recruiting lymphocytes inflamed human liver are not known. E–selectin, which acts as an addressin for a subset skin–infiltrating T cells express distinct E–selectin ligand called the cutaneous lymphocyte antigen (CLA), can be detected endothelium inflammatory diseases suggesting it might also act...
Background Endoscopy within 24 h of admission (early endoscopy) is a quality standard in acute upper gastrointestinal bleeding (AUGIB). We aimed to audit time endoscopy outcomes and identify factors affecting delayed (>24 admission). Methods This prospective multicentre enrolled patients admitted with AUGIB who underwent inpatient between November December 2017. Analyses were performed associated endoscopy, compare patient outcomes, including length stay mortality rates, early groups....
Aims and Methods: Oxidant stress is proposed to be an important pathogenic factor in liver damage related alcohol. The glutathione S-transferases (GSTs) are a group of polymorphic enzymes that protection against oxidant stress. As there evidence for genetic susceptibility alcohol-related disease we have compared the frequency polymorphisms GSTM1, M3, P1, T1 A1 by polymerase chain reaction (PCR) on leucocyte DNA patients from North Staffordshire, Birmingham Liverpool with chronic heavy...
In the course of a work-up for fever unknown origin associated with intermittent arrhythmias, gallium scan was performed which revealed diffuse myocardial uptake. The diagnosis Lyme disease myocarditis subsequently confirmed by serologic titers. One month following recovery from acute illness, abnormal uptake completely resolved.
Findings in the literature are conflicting on whether trainee involvement endoscopic retrograde cholangiopancreatography (ERCP) procedures is detrimental to cannulation success rates. We addressed this a prospective study, where with or without presence was primary outcome measure. prospectively recorded data 2 senior endoscopists and their trainees over an 18-month period for ERCPs patients virgin ampulla. Presence absence of at ERCP pragmatic, reflecting other service training commitments...
We reviewed the use of liposomal amphotericin B in 30 patients receiving therapy following liver transplantation over a 2 year period. Five these were treated for presumed invasive aspergillosis: four them died despite therapy, each having combined renal and respiratory failure at time diagnosis aspergillosis. Post-mortem examination three confirmed Twenty-five empirically; 11 supportive evidence fungal infection commencement was found only one case. Following transplantation, confirmation...
Fisher, N. C. M.R.C.P.; Tutt, A. Sim, E. M.D. F.R.C.P.; Scarpello, J. H. B. M.D.,F.R.C.P.; Green, R. M.R.C.Path. Author Information
Abstract Background Percutaneous endoscopic gastrostomy (PEG) tubes allow for long-term enteral feeding. Disk-retained PEG may be suitable usage without planned replacement, but data on longevity are limited. We aimed to assess the rates and predictors of post-PEG mortality. Design Single-centred retrospective cohort study patients with disk-retained (Freka) tubes. Methods All undergoing between 2010 2013 were identified, analysis outcomes until 2017 (median 1062 days) was performed....
Fungal infection, particularly with Candida spp., has been identified as an important cause of morbidity and mortality in patients acute liver failure. colonisation superficial mucosal sites usually precedes invasive infection. We investigated patterns disease receiving fluconazole therapy order to investigate the possibility emergence fluconazole-resistant C. albicans or other species.During a 6-month study period, we studied all referred our unit by twice-weekly sampling mycological...