Daniel Clerc
A5033353173- Colorectal Cancer Surgical Treatments
- Cardiac, Anesthesia and Surgical Outcomes
- Occupational and environmental lung diseases
- Pleural and Pulmonary Diseases
- Enhanced Recovery After Surgery
- Appendicitis Diagnosis and Management
- Medical Imaging and Pathology Studies
- Surgical site infection prevention
- Hepatocellular Carcinoma Treatment and Prognosis
- Anorectal Disease Treatments and Outcomes
- Colorectal and Anal Carcinomas
- Intraperitoneal and Appendiceal Malignancies
- Diverticular Disease and Complications
- Hernia repair and management
- Radiation Dose and Imaging
- Gastric Cancer Management and Outcomes
- Global Health and Surgery
- Clinical practice guidelines implementation
- Colorectal Cancer Screening and Detection
- Cancer Research and Treatments
- Gastrointestinal disorders and treatments
- Clostridium difficile and Clostridium perfringens research
- Stoma care and complications
- Cancer Mechanisms and Therapy
- Fetal and Pediatric Neurological Disorders
University of Lausanne
2012-2025
Ospedale di San Donà di Piave
2025
Hôpital de Sion
2025
University Hospital of Lausanne
2014-2023
Hôpital Orthopédique de la Suisse Romande
2011-2019
Hôpital Riviera-Chablais
2018
In 2012, the Department of Visceral Surgery Lausanne University Hospital CHUV implemented a dedicated high-resolution anoscopy (HRA) outpatient clinic for surveillance and follow-up purposes. This 10-year longitudinal study analyzed 537 patients (2214 visits) using structured screening protocol. Dysplastic lesions were detected in 49% patients, predominantly low-grade squamous intraepithelial (LSILs, 74%). Among LSIL cases, 6% progressed to high-grade (HSILs) within 24 months, reaching 25%...
Lower endoscopy (LE) is the standard diagnostic modality for lower gastrointestinal bleeding (LGIB). Conversely, computed tomographic angiography (CTA) offers an immediate non-invasive diagnosis visualizing entire tract. The aim of this study was to compare these 2 modalities with regards value and control.Tertiary center retrospective analysis consecutive patients admitted LGIB between 2006 2012. Comparison LE vs. CTA as first exam, respectively, emphasis on accuracy control.Final included...
Abstract Background Ileus is common after elective colorectal surgery, and associated with increased adverse events prolonged hospital stay. The aim was to assess the role of non-steroidal anti-inflammatory drugs (NSAIDs) for reducing ileus surgery. Methods A prospective multicentre cohort study delivered by an international, student- trainee-led collaborative group. Adult patients undergoing resection between January April 2018 were included. primary outcome time gastrointestinal recovery,...
Surgical site infection after stoma reversal is common. The optimal skin closure technique has been widely debated in the literature.We hypothesized that pursestring near-complete of would lead to fewer surgical infections compared with conventional primary closure.This study was a parallel prospective multicenter randomized controlled trial.This conducted at 2 university medical centers.Patients (N = 122) presenting for elective colostomy or ileostomy were selected.Pursestring versus sites...
<div>Abstract<p>Pleural mesothelioma is a fatal disease with limited treatment options. Recently, pleural management has improved the development of immune checkpoint inhibitors (ICI). In first-line therapy, dual PD-1 and CTLA-4 blockade enhances tumor control patient survival compared chemotherapy. Unfortunately, only fraction patients responsive to immunotherapy, approaches reshape microenvironment make ICIs more effective are urgently required. this study, we evaluated effect...
<p>Supplementary Figure S5: Impact of HITOC on tumor-infiltrating T cells.</p>
<p>Supplementary Figure S3: Representative flow cytometry histograms.</p>
<p>Supplementary Figure S4: Effect of HITOC on CD4 T cell infiltration in tumors.</p>
<p>Supplementary Figure S1: Evaluation of the impact heat adjunct on cisplatin cytotoxicity.</p>
<p>Supplementary Figure S6: Effect of HITOC on PD-1 and CTLA-4 expression by CD4 T cells.</p>
<p>Supplementary Figure S2: Flow cytometry gating.</p>
Morbidity and mortality associated with bariatric surgery are considered low. The aim of this study is to assess the incidence, clinical presentation, risk factors, management early postoperative bleeding (POB) after laparoscopic Roux-en-Y gastric by-pass (RYGB).Retrospective analysis prospectively collected data consecutive patients who underwent RYGB in 2 expert centers between January 1999 April 2020, a common surgeon.A total 2639 were included study. POB occurred 72 (2.7%). Intraluminal...
Abstract Background Ileus is common after colorectal surgery and associated with an increased risk of postoperative complications. Identifying features normal bowel recovery the appropriateness for hospital discharge challenging. This study explored safety before return function. Methods A prospective, multicentre cohort was undertaken across international collaborative network. Adult patients undergoing elective resection between January April 2018 were included. The main outcome interest...
Avoiding 'mini-laparotomy' to extract a colectomy specimen may decrease wound complications and further improve recovery after laparoscopic surgery. The aim of this study was develop new technique for transrectal extraction (TRSE) compare it with conventional laparoscopy (CL) left sided colectomy.Eleven patients benign disease requiring either sigmoid or colon resection underwent TRSE. unfired circular stapler inserted transanally used as guide suture-close the recto-sigmoid junction...
Abstract Objectives To assess the interobserver reliability (IOR) of Tile classification system, and its potential influence on outcomes, for interpretation CT images pelvic fractures by radiologists surgeons. Methods Retrospective data (1/2008–12/2016) from 238 patients with were analyzed. Mean patient age was 44 years (SD 20); 66% male. There 54 A, 82 B, 102 C type injuries. The 30-day mortality rate 15% (36/238). Six observers, three radiologists, surgeons different levels experience...
QUESTION UNDER STUDY: To investigate the change over time in number of ED admissions with positive blood alcohol concentration (BAC) and to evaluate predictors BAC level. METHODS: We conducted a single site retrospective study at tertiary referral hospital (western part Switzerland) obtained all performed from 2002 2011. determined proportion (number BAC/number admissions). Regression models assessed trends level among patients BAC. RESULTS: A total 319,489 were recorded 20,021 tests...
Enhanced recovery after surgery (ERAS) pathways proved to reduce complications, length of hospital stay and costs colorectal surgery. Standardized discharge criteria have been established that are fulfilled complete medical is achieved. This study aimed assess the timing in relation actual discharge, reasons for prolonged within an ERAS pathway.One hundred fourteen consecutive patients undergoing elective pathway were included this prospective analysis. Fulfillment was assessed daily...
Pressurized intraperitoneal aerosol chemotherapy (PIPAC) is a promising treatment for peritoneal cancer that entails, however, potential risks the caregivers in operating room (OR). This study aimed to reach consensus within PIPAC community on comprehensive safety protocol.Active centers were invited participate two-round Delphi process 43 predefined items: concise summaries of existing evidence presented together with questions formulated using population, intervention, comparator, and...
Background: Anxiety is common before surgery and known to negatively impact recovery from surgery. The aim of this study was evaluate the a preoperative nurse dialogue on patient’s anxiety, satisfaction early postoperative outcomes. Method: This 1:1 randomized controlled trial compared patients undergoing major visceral after semistructured (interventional group: IG) control group (CG) without nursing intervention prior measured with autoevaluation scale State-Trait Inventory (STAI, Y-form)...