A5006411743- Cardiac, Anesthesia and Surgical Outcomes
- Canadian Identity and History
- American Environmental and Regional History
- COVID-19 and healthcare impacts
- Architecture, Design, and Social History
- Liver Diseases and Immunity
- Trauma and Emergency Care Studies
- Lipoproteins and Cardiovascular Health
- Acute Kidney Injury Research
- Health disparities and outcomes
- Bariatric Surgery and Outcomes
- Liver Disease Diagnosis and Treatment
- Plant tissue culture and regeneration
- Cardiac Fibrosis and Remodeling
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Heparin-Induced Thrombocytopenia and Thrombosis
- Enhanced Recovery After Surgery
- Cancer, Lipids, and Metabolism
- Birth, Development, and Health
- Flowering Plant Growth and Cultivation
- Inflammatory Bowel Disease
- Intergenerational and Educational Inequality Studies
- Atherosclerosis and Cardiovascular Diseases
- Medical Imaging and Analysis
- Abdominal Surgery and Complications
Cardiff University
2019-2023
British Heart Foundation
2016-2022
Institut de Virologie
2020-2021
Public Health Wales
2021
University of Bristol
2018-2021
Universities UK
2021
University of Birmingham
2020
AstraZeneca (Brazil)
2020
Stryker (United Kingdom)
2020
Pfizer (United Kingdom)
2020
Recent data has suggested that the 5-hydroxytryptamine (5-HT)<sub>1A</sub> receptor is involved in cognitive processing. A novel 5-HT<sub>1A</sub> antagonist, 4-cyano-<i>N</i>-{2<i>R</i>-[4-(2,3-dihydrobenzo[1,4]-dioxin-5-yl)-piperazin-1-yl]-propyl}-<i>N</i>-pyridin-2-yl-benzamide HCl (lecozotan), which been characterized multiple vitro and vivo pharmacological assays as a drug to treat dysfunction, reported. In binding intrinsic activity determinations demonstrated lecozotan potent...
Acute inflammation impairs reverse cholesterol transport (RCT) and reduces high-density lipoprotein (HDL) function in vivo. This study hypothesized that obesity-induced impedes RCT alters HDL composition, investigated if dietary replacement of saturated (SFA) for monounsaturated (MUFA) fatty acids modulates RCT.Macrophage-to-feces RCT, efflux capacity, proteomic profiling was determined C57BL/6j mice following 24 weeks on SFA- or MUFA-enriched high-fat diets (HFDs) low-fat diet. The impact...
To create a model of atherosclerosis using green fluorescent protein (GFP)-targeted monocytes/macrophages, allowing analysis both endogenous GFP+ and adoptively transferred myeloid cells in arterial inflammation. APPROACH AND RESULTS: hCD68GFP reporter mice were crossed with ApoE-/- mice. Expression GFP was localized to macrophages atherosclerotic plaques angiotensin II-induced aortic aneurysms correlated galectin 3 mCD68 expression. Flow cytometry confirmed expression CD11b+/CD64+,...
Abstract Background Ileus is common after colorectal surgery and associated with an increased risk of postoperative complications. Identifying features normal bowel recovery the appropriateness for hospital discharge challenging. This study explored safety before return function. Methods A prospective, multicentre cohort was undertaken across international collaborative network. Adult patients undergoing elective resection between January April 2018 were included. The main outcome interest...
Background Education is inversely associated with cardiovascular disease (CVD). Several mediators of this have been established; however, a proportion the protective effect remains unaccounted for. Mental health proposed mediator, but current evidence mixed and subject to bias from confounding factors reverse causation. Mendelian randomization an instrumental variable technique that uses genetic proxies for exposures reduce such bias. Methods Results We performed logistic regression 2-step...
Abstract Of the four common alkaline earth cations, only Ca ++ is able to protect Rana pipiens embryos from dissociation of epidermis into isolated cells by EDTA. Presumably this because satisfy divalent cation requirement for cellular adhesion in tissue. Although early stage are completely dissociable EDTA, axial musculature, brain and spinal cord become resistant 17. Tetraphenyl boron also effective disaggregating amphibian embryo tissues.
Abstract Background Previous observational evidence has suggested an association between smoking and inflammatory bowel disease (IBD). Methods We used techniques followed by Mendelian randomization to explore whether is a causal factor in the development of IBD its subtypes. Results In those who have ever smoked, we observed increased risk and, current smokers, Crohn decreased ulcerative colitis. However, our analyses found little that affects IBD. Conclusion Overall, results suggest does...
Missed fractures are the most frequent diagnostic error attributed to clinicians in UK emergency departments and a significant cause of patient morbidity. Recently, advances computer vision have led artificial intelligence (AI)-enhanced model developments, which can support detection fractures. Previous research has shown these models promising effects on performance, but their impact accuracy National Health Service (NHS) setting not yet been fully evaluated.
This chapter will deal with methods of clonal propagation for members the two major morphological groups orchids. The first group, sympodials, includes such genera as Cymbidium, Cattleya, Dendrobium, and Oncidium. They are characterized by a multi-branchingrhizome that can supply an abundance axillary shoots use explants. were among orchids to be successfully propagated, techniques their in vitro initiation (i.e., establishment) subsequent proliferation well established (1-8). second...
A best evidence topic in thoracic surgery was written according to a structured protocol. The question addressed 'Is microwave ablation (MWA) more effective than radiofrequency (RFA) achieving local control for primary lung cancer?'. Altogether, 439 papers were found, of which 7 represented the answer clinical question. authors, journal, date and country publication, patient group studied, study type, relevant outcomes results these are tabulated. Both thermal ablative techniques, with newer...
Joseph and his Brethren Get access D. Jones Search for other works by this author on: Oxford Academic Google Scholar Notes Queries, Volume s3-VIII, Issue 185, 15 July 1865, Page 60, https://doi.org/10.1093/nq/s3-VIII.185.60c Published: 1865
The growth-enhancing property of DCPTA was tested on transplanted seedlings Brassolaeliocattleya × Hort. (Blc. Bryce Canyon Lc. Pirate King), Dendrobium Blume. Hickham Deb, Epidendrum radicans Pav. ex Lindl., Lueliocattleya Rolfe Prism Palette `The Clown', and Phalaenopsis [Pink Zebra (Jutta Brungor Music)]. After 3 to 6 months greenhouse growth, plants treated with 30 μ m produced a 2- 3-fold increase in root growth compared the controls. Shoot root: shoot ratio, survival DCPTA-treated were...
As part of a study mechanisms that produce acid mine drainage, we made laboratory<br>and field studies two dumps near Silver-ton, CO. Water drains from both dumps<br>during spring to mid-summer had been found be quite acidic. The contained broken-up<br>material excavated Pb-Zn-Ag prospects. In laboratory and measurements we<br>found the resistivities dump material varied substantially, while their spectral induced<br>polarization (SIP) characteristics were...