A5069728563- Cancer Research and Treatments
- Liver Disease Diagnosis and Treatment
- Metal-Catalyzed Oxygenation Mechanisms
- Colorectal Cancer Treatments and Studies
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Gastric Cancer Management and Outcomes
- Amino Acid Enzymes and Metabolism
- Genetic factors in colorectal cancer
- Cancer, Lipids, and Metabolism
- Colorectal Cancer Screening and Detection
- Nutrition and Health in Aging
- Cancer Genomics and Diagnostics
- Cancer Treatment and Pharmacology
- Epigenetics and DNA Methylation
- Viral-associated cancers and disorders
- Economic and Financial Impacts of Cancer
- Single-cell and spatial transcriptomics
- Colorectal Cancer Surgical Treatments
- Health Systems, Economic Evaluations, Quality of Life
- Cancer Risks and Factors
- GDF15 and Related Biomarkers
- Frailty in Older Adults
- Macrophage Migration Inhibitory Factor
- Adipokines, Inflammation, and Metabolic Diseases
- Cancer survivorship and care
National Cancer Centre Singapore
2015-2024
Duke-NUS Medical School
2021-2023
National University of Singapore
2022-2023
Harvard University
2015-2017
Massachusetts General Hospital
2015-2017
Norfolk and Norwich University Hospital
2012
The most recent version of the European Society for Medical Oncology (ESMO) consensus guidelines treatment patients with metastatic colorectal cancer (mCRC) was published in 2016, identifying both a more strategic approach to administration available systemic therapy choices, and greater emphasis on use ablative techniques, including surgery. At 2016 ESMO Asia Meeting, December it decided by Japanese (JSMO) convene special meeting, endorsed JSMO, immediately after JSMO 2017 Annual Meeting....
Abstract The consensus molecular subtype (CMS) classification of colorectal cancer is based on bulk transcriptomics. underlying epithelial cell diversity remains unclear. We analyzed 373,058 single-cell transcriptomes from 63 patients, focusing 49,155 cells. identified a pervasive genetic and transcriptomic dichotomy malignant cells, distinct gene expression, DNA copy number regulatory network. recapitulated these subtypes in 3,614 patients. two intrinsic subtypes, iCMS2 iCMS3, refine CMS....
While tobacco and alcohol are established risk factors for hepatocellular carcinoma (HCC), the most common type of primary liver cancer, it is unknown whether they also increase intrahepatic cholangiocarcinoma (ICC). Thus, we examined association between use by cancer type.
Prospective data on the risk of hepatocellular carcinoma (HCC) according to dose and duration aspirin therapy are limited.To examine potential benefits use for primary HCC prevention at a range doses durations within 2 prospective, nationwide populations.Pooled analysis prospective US cohort studies: Nurses' Health Study Professionals Follow-up Study. Data were accessed from November 1, 2017, through March 7, 2018. A total 133 371 health care professionals who reported use, frequency,...
Type 2 diabetes (T2D) is a risk factor for hepatocellular carcinoma (HCC). However, it unknown whether T2D duration or additional metabolic comorbidities further contribute to HCC risk. From the Nurses' Health Study (NHS), 120,826 women were enrolled in 1980, and from Professionals Follow‐up (HPFS), 50,284 men 1986 followed through 2012. Physician‐diagnosed was ascertained at baseline updated biennially. Cox proportional hazards regression models used calculate age‐ multivariable‐adjusted...
Abstract Profiling of circulating tumor DNA (ctDNA) may offer a non-invasive approach to monitor disease progression. Here, we develop quantitative method, exploiting local tissue-specific cell-free (cfDNA) degradation patterns, that accurately estimates ctDNA burden independent genomic aberrations. Nucleosome-dependent cfDNA at promoters and first exon-intron junctions is strongly associated with differential transcriptional activity in tumors blood. A model, based on just 6 regulatory...
The European Society for Medical Oncology (ESMO) Clinical Practice Guidelines the diagnosis, treatment and follow-up of patients with metastatic colorectal cancer (mCRC), published in late 2022, were adapted December according to previously established standard methodology, produce Pan-Asian (PAGA) ESMO consensus guidelines management Asian mCRC. presented this manuscript represent opinions reached by a panel experts mCRC representing oncological societies China (CSCO), Indonesia (ISHMO),...
Background and Aims In almost all countries, incidence rates of liver cancer (LC) are 100%‐200% higher in males than females. However, this difference is predominantly driven by hepatocellular carcinoma (HCC), which accounts for 75% LC cases. Intrahepatic cholangiocarcinoma (ICC) 12% cases has only 30% males. Hormones hypothesized to underlie observed sex differences. We investigated whether prediagnostic circulating hormone binding globulin (SHBG) levels were associated with risk, overall...
The treatment of glioblastoma multiforme (GBM) is an unmet clinical need. 5-year survival rate patients with GBM less than 3%. Temozolomide (TMZ) remains the standard first-line regimen for gliomas despite fact that more 90% recurrent do not respond to TMZ after repeated exposure. We have also independently shown many Asian-derived glioma cell lines and primary cells derived from Singaporean high-grade are indeed resistant TMZ. This issue highlights need develop new effective anti-cancer...
Obesity is known to be associated with primary liver cancer (PLC), but the separate effects of excess abdominal and gluteofemoral size are unclear. Thus, we examined association between waist hip circumference risk PLC overall by histologic type-hepatocellular carcinoma (HCC) intrahepatic cholangiocarcinoma (ICC). The Liver Cancer Pooling Project a consortium prospective cohort studies that include data from 1,167,244 individuals (PLC n = 2,208, HCC 1,154, ICC 335). Multivariable-adjusted...
Over-consumption of iron-rich red meat and hereditary or genetic iron overload are associated with increased risk colorectal carcinogenesis, yet the mechanistic basis how metal-mediated signaling leads to oncogenesis remains enigmatic. Using fresh cancer (CRC) samples we identify Pirin, an sensor, that overcomes a rate-limiting step in oncogenesis, by re-activating dormant human-reverse-transcriptase (hTERT) subunit telomerase holoenzyme iron-(Fe3+)-dependent-manner thereby drives CRCs....
Genome-wide analysis of cell-free DNA methylation profile is a promising approach for sensitive and specific detection many cancers. However, scaling such assays clinical translation impractical because the high cost whole-genome bisulfite sequencing. We show that small fraction GC-rich genome highly enriched in CpG sites disproportionately harbors most cancer-specific signature. Here, we report on simple effective heat enrichment CpG-rich regions sequencing (Heatrich-BS) platform allows...
5-Methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC) are the most abundant DNA modifications that have important roles in gene regulation. Detailed studies of these different epigenetic marks aimed at understanding their combined effects dynamic interconversion are, however, hampered by inability current methods to simultaneously measure both modifications, particularly samples with limited quantities. We present analysis restriction enzyme for simultaneous detection multiple epigenomic...
<div>Abstract<p>Over-consumption of iron-rich red meat and hereditary or genetic iron overload are associated with an increased risk colorectal carcinogenesis, yet the mechanistic basis how metal-mediated signaling leads to oncogenesis remains enigmatic. Using fresh cancer samples we identify Pirin, sensor, that overcomes a rate-limiting step in oncogenesis, by reactivating dormant human telomerase reverse transcriptase (hTERT) subunit holoenzyme...
Biennial screening for colorectal cancer using faecal occult blood testing has been shown to reduce the relative risk of mortality from cancer. The Norwich centre commenced in July 2006 and so far diagnosed over 350 patients with We compared stage at diagnosis cancer-specific survival through a cohort symptomatic within same age range.A comparative analysis was undertaken all screen-detected between December 2010, an age-matched group Norfolk Hospital 2-week suspected guidelines.Three...
Prospective data are limited regarding dynamic adulthood weight changes and hepatocellular carcinoma (HCC) risk. We included 77,238 women (1980-2012) 48,026 men (1986-2012), who recalled young-adult [age 18 years (women); 21 (men)], provided biennially updated information weight, body mass index (BMI), comorbidities. Overall change was defined as the difference in (kilograms) between young-adulthood present. Using Cox proportional hazards models, we calculated multivariable adjusted HRs...
Abstract Aim As populations age and cancer management improves, long‐term survivorship quality‐of‐life (QOL) outcomes are becoming equally important as oncological results. Data from Asian scarce. We aimed to evaluate the sexual health, gastrointestinal function QOL amongst colorectal survivors in a tertiary referral centre Singapore. Method Adults who had undergone elective curative surgery for non‐metastatic at least 2 years prior were included. Exclusion criteria cognitive disease,...
Aim To evaluate the safety and efficacy of combination therapy fluorouracil, leucovorin irinotecan (FOLFIRI) aflibercept in Asian patients with metastatic colorectal cancer (mCRC), who had progressed after oxaliplatin-based chemotherapy. Methods This is a retrospective analysis 19 mCRC received FOLFIRI (4 mg/kg intravenously) every 2 weeks via Named Patient Program (supported by Sanofi Aventis) Singapore. Treatment was administered until disease progression or unacceptable toxicities....
Colorectal cancer is among the top three most commonly occurring cancers worldwide, and around 30-40% of patients treated by curative intent surgery will experience recurrence. Proactive prognostication would enable clinicians to better plan treatment modality intensity, follow-up frequency reduce Here, we study application machine learning models predict recurrence in a cohort 904 post-resection colorectal patients. We employ heterogeneous structured temporal clinical features including...