A5072771762- Aortic aneurysm repair treatments
- Cancer Research and Treatments
- Aortic Disease and Treatment Approaches
- Colorectal Cancer Surgical Treatments
- Vascular Procedures and Complications
- Metal-Catalyzed Oxygenation Mechanisms
- Cardiac, Anesthesia and Surgical Outcomes
- Central Venous Catheters and Hemodialysis
- Cardiac Valve Diseases and Treatments
- Hepatocellular Carcinoma Treatment and Prognosis
- Amino Acid Enzymes and Metabolism
- Gastric Cancer Management and Outcomes
- Peripheral Artery Disease Management
- Infective Endocarditis Diagnosis and Management
- Vascular Malformations Diagnosis and Treatment
- Pancreatic and Hepatic Oncology Research
- Enhanced Recovery After Surgery
- Nutrition and Health in Aging
- Colorectal and Anal Carcinomas
- Anorectal Disease Treatments and Outcomes
- Pelvic floor disorders treatments
- Infectious Aortic and Vascular Conditions
- Mosquito-borne diseases and control
- Cerebrovascular and Carotid Artery Diseases
- Cardiovascular Health and Disease Prevention
Singapore General Hospital
2019-2024
National University of Singapore
2017-2023
Yahoo (United Kingdom)
2023
National Cancer Centre Singapore
2023
Singapore Management University
2022
National University Health System
2018-2021
SingHealth Polyclinics
2017-2021
UNSW Sydney
2018-2020
Changi General Hospital
2020
National University Cancer Institute, Singapore
2018
Over-consumption of iron-rich red meat and hereditary or genetic iron overload are associated with increased risk colorectal carcinogenesis, yet the mechanistic basis how metal-mediated signaling leads to oncogenesis remains enigmatic. Using fresh cancer (CRC) samples we identify Pirin, an sensor, that overcomes a rate-limiting step in oncogenesis, by re-activating dormant human-reverse-transcriptase (hTERT) subunit telomerase holoenzyme iron-(Fe3+)-dependent-manner thereby drives CRCs....