A5011476953- Cancer Research and Treatments
- Metal-Catalyzed Oxygenation Mechanisms
- Poxvirus research and outbreaks
- Plant Virus Research Studies
- Amino Acid Enzymes and Metabolism
- Herpesvirus Infections and Treatments
- SARS-CoV-2 and COVID-19 Research
- Virus-based gene therapy research
- Viral Infections and Immunology Research
- vaccines and immunoinformatics approaches
- Bacteriophages and microbial interactions
- Computational Drug Discovery Methods
- Viral gastroenteritis research and epidemiology
- Virology and Viral Diseases
- Immunotherapy and Immune Responses
- Animal Disease Management and Epidemiology
- Influenza Virus Research Studies
- Enzyme Structure and Function
- RNA and protein synthesis mechanisms
- DNA and Nucleic Acid Chemistry
- Digestive system and related health
- Monoclonal and Polyclonal Antibodies Research
- Telomeres, Telomerase, and Senescence
- Plant and Fungal Interactions Research
- interferon and immune responses
Indian Institute of Technology Indore
2019-2024
Institute of Molecular and Cell Biology
2024
Agency for Science, Technology and Research
2024
Zika virus (ZIKV), a mosquito-transmitted Flavivirus, emerged in the last decade causing serious diseases and affecting human health globally. Currently, no licensed vaccines or antivirals are available to combat ZIKV, although several vaccine candidates pipeline. In recent years, presence of non-canonical G-quadruplex (GQ) secondary structures viral genomes has ignited significant attention as potential targets for antiviral strategy. this study, we identified novel conserved GQ by...
Abstract The G-quadruplex (GQ) motifs are considered as potential drug-target sites for several human pathogenic viruses such Zika, Hepatitis, Ebola, and Human Herpesviruses. recent outbreaks of Nipah virus (NiV) in India, the highly fatal emerging zoonotic is a threat to global health security no anti-viral drug or vaccine currently available. Therefore, here present study, we sought assess ability putative forming sequences NiV genome form structures act targets compounds. Bioinformatics...
Nipah virus (NPV) is one of the most notorious viruses with a very high fatality rate. Because recurrent advent this and its severe neurological implications, often leading to mortality, WHO R&D Blueprint, 2018 has listed as emerging infectious diseases requiring urgent research development effort. Yet there major layback in effective vaccines or drugs against NPV. In study, we have designed stable multivalent vaccine combining several T-cell B-cell epitopes essential viral proteins help...
Over-consumption of iron-rich red meat and hereditary or genetic iron overload are associated with increased risk colorectal carcinogenesis, yet the mechanistic basis how metal-mediated signaling leads to oncogenesis remains enigmatic. Using fresh cancer (CRC) samples we identify Pirin, an sensor, that overcomes a rate-limiting step in oncogenesis, by re-activating dormant human-reverse-transcriptase (hTERT) subunit telomerase holoenzyme iron-(Fe3+)-dependent-manner thereby drives CRCs....
The colloidal stabilization of multiwalled carbon nanotubes (MWCNTs) in an aqueous medium through noncovalent interactions has potential benefits toward the practical use this one-dimensional carbonaceous material for biomedical applications. Here, we report that fluorescent nanodots can efficiently function as dispersing agents preparation stable suspensions CNTs at significant concentrations (0.5 mg/mL). amphiphilic nature dots with a hydrophobic graphitic core could effectively interact...
Vibrio cholerae, a gram-negative bacterium that causes cholera, has already caused seven major pandemics across the world and infects roughly 1.3-4 million people every year. Cholera treatment primarily involves oral rehydration therapy supplemented with antibiotics. But recently, multidrug-resistant strains of V. cholerae have emerged. High genomic plasticity further enhances pathogenesis this human pathogen. Guanines in DNA or RNA assemble to form G-quadruplex (GQ) structures which begun...
Abstract Genome-wide in-silico identification of microsatellites or simple sequence repeats (SSRs) in the Orf virus (ORFV), causative agent contagious ecthyma has been carried out to investigate type, distribution and its potential role genome evolution. We have investigated eleven ORFV strains, which resulted presence 1,036–1,181 per strain. The further screening revealed 83–107 compound SSRs (cSSRs) genome. Our analysis indicates dinucleotide (76.9%) be most abundant, followed by...
<div>Abstract<p>Over-consumption of iron-rich red meat and hereditary or genetic iron overload are associated with an increased risk colorectal carcinogenesis, yet the mechanistic basis how metal-mediated signaling leads to oncogenesis remains enigmatic. Using fresh cancer samples we identify Pirin, sensor, that overcomes a rate-limiting step in oncogenesis, by reactivating dormant human telomerase reverse transcriptase (hTERT) subunit holoenzyme...
G-quadruplexes (GQs) have been primarily studied in the context of cancer and neurodegenerative pathologies. However, recent research has shifted focus to their existence functional roles viral genomes, revealing GQ-regulated key pathways various human pathogenic viruses. While GQ structures reported genomes emerging re-emerging viruses, RNA viruses understudied compared DNA including notable examples such as immunodeficiency virus-1, hepatitis C virus, Ebola Nipah Zika SARS-CoV-2. The...
During the years 2010-2018, avipoxvirus (APV) outbreaks were observed in domestic chickens and pigeons present eastern Indian state of Odisha. Based on typical pox lesions, followed by molecular techniques, overall morbidity was found to be 18%-19.23% 16.92%-23% pigeons, respectively. The cutaneous forms disease with varied rates mortality, being 47.36%-52.77% 39.13%-92% pigeons. PCR amplification targeting viral P4b core protein-coding gene DNA polymerase confirmed presence APV strains 10...
The recent ongoing pandemic caused by SARS-CoV-2 continues to impose devastating impacts and is accountable for the loss of more than 250,000 human lives within a short span four months. This urges immediate therapeutic measures control impact this disease. One most conserved potentially druggable sites Nsp16 active site that performs 2’-O-methyltransferase activity puts 5’ cap on viral RNA molecules. allows them mimic endogenous transcripts efficient translation proteins evasion immune...
ABSTRACT Novel SARS coronavirus (SARS-CoV-2) has caused a pandemic condition world-wide and been declared as public health emergency of International concern by WHO in very short span time. The community transmission this highly infectious virus severely affected various parts China, Italy, Spain USA among others. prophylactic solution against SARS-CoV-2 infection is challenging due to the high mutation rate its RNA genome. Herein, we exploited next generation vaccinology approach construct...
<p>The recent ongoing pandemic caused by SARS-CoV-2 continues to impose devastating impacts and is accountable for the loss of more than 250,000 human lives within a short span four months. This urges immediate therapeutic measures control impact this disease. One most conserved potentially druggable sites Nsp16 active site that performs 2’-O-methyltransferase activity puts 5’ cap on viral RNA molecules. allows them mimic endogenous transcripts efficient translation proteins evasion...
<p>ITDRF-CETSA method identifying SP2509’s target.</p>
<p>SP2509 competes with Iron-(Fe<sup>3+</sup>) bound to Pirin</p>
<p>Role of Iron-(Fe<sup>3+</sup>) and Pirin in CRC</p>
<p>Effect of LSD1 on hTERT expression and telomerase activity.</p>
<p>Role of Iron-(Fe<sup>3+</sup>) and Pirin in CRC</p>
<p>Regulation of Sp1 and FBXW7 levels by Pirin SP2509</p>