A5101525689- Mosquito-borne diseases and control
- Viral Infections and Vectors
- Insect symbiosis and bacterial influences
- Virology and Viral Diseases
- Bacteriophages and microbial interactions
- Plant Virus Research Studies
- vaccines and immunoinformatics approaches
- Malaria Research and Control
- SARS-CoV-2 and COVID-19 Research
- Genomics, phytochemicals, and oxidative stress
- Alzheimer's disease research and treatments
- Monoclonal and Polyclonal Antibodies Research
- Transgenic Plants and Applications
- RNA and protein synthesis mechanisms
University of Nebraska–Lincoln
2017-2024
Zika virus (ZIKV), a mosquito-transmitted flavivirus responsible for sporadic outbreaks of mild and febrile illness in Africa Asia, reemerged the last decade causing serious human diseases, including microcephaly, congenital malformations, Guillain-Barré syndrome. Although genomic phylogenetic analyses suggest that genetic evolution may have led to enhanced virulence ZIKV, experimental evidence supporting role specific changes is currently lacking. One sequence motif, VNDT, containing an...
Zika virus (ZIKV), a mosquito-transmitted Flavivirus, emerged in the last decade causing serious diseases and affecting human health globally. Currently, no licensed vaccines or antivirals are available to combat ZIKV, although several vaccine candidates pipeline. In recent years, presence of non-canonical G-quadruplex (GQ) secondary structures viral genomes has ignited significant attention as potential targets for antiviral strategy. this study, we identified novel conserved GQ by...
The severe consequences of the Zika virus (ZIKV) infections resulting in congenital syndrome infants and autoimmune Guillain–Barre adults warrant development safe efficacious vaccines therapeutics. Currently, there are no approved treatment options for ZIKV infection. Herein, we describe a bacterial ferritin-based nanoparticle vaccine candidate ZIKV. viral envelope (E) protein domain III (DIII) was fused in-frame at amino-terminus ferritin. displaying DIII examined its ability to induce...
Zika virus (ZIKV) is a major public health concern of international proportions. While the incidence ZIKV infections has declined substantially in recent years, potential for reemergence or reintroduction remains high.
Zika virus (ZIKV), a mosquito-transmitted flavivirus, is linked to microcephaly and other neurological defects in neonates Guillain-Barré syndrome adults. The molecular mechanisms regulating ZIKV infection pathogenic outcomes are incompletely understood. Signaling by the mechanistic (mammalian) target of rapamycin (mTOR) kinase important for cell survival proliferation, viruses known hijack this pathway their replication. Here, we show that human neuronal precursors glial cells culture,...
Vaccines are one of the most effective medical interventions, playing a pivotal role in treating infectious diseases. Although traditional vaccines comprise killed, inactivated, or live-attenuated pathogens that have resulted protective immune responses, negative consequences their administration been well appreciated. Modern evolved to contain purified antigenic subunits, epitopes, antigen-encoding mRNAs, rendering them relatively safe. However, reduced humoral and cellular responses pose...
Zika virus (ZIKV), a mosquito-transmitted flavivirus, emerged in the last decade causing serious human diseases, including congenital microcephaly newborns and Guillain-Barré syndrome adults. Although many vaccine platforms are at various stages of development, no licensed vaccines currently available. Previously, we described mutant MR766 ZIKV (m2MR) bearing an E protein mutation (N154A) that prevented its glycosylation, resulting attenuation defective neuroinvasion. To further attenuate...
Vaccines are one of the most effective medical interventions, playing a pivotal role in treating infectious diseases. Although traditional vaccines comprising killed, inactivated, or live attenuated pathogens have resulted protective immune responses, negative consequences their administration been well-appreciated. Modern evolved to contain purified antigenic proteins, epitopes, antigen-encoding mRNAs, rendering them relatively safe. However, reduced humoral and cellular responses pose...