A5009015359- Genomics, phytochemicals, and oxidative stress
- Autophagy in Disease and Therapy
- Redox biology and oxidative stress
- Parkinson's Disease Mechanisms and Treatments
- Neuroscience and Neuropharmacology Research
- Glutathione Transferases and Polymorphisms
- Aldose Reductase and Taurine
- Epigenetics and DNA Methylation
- Sulfur Compounds in Biology
- Histone Deacetylase Inhibitors Research
- Trace Elements in Health
- Ion Transport and Channel Regulation
- Mitochondrial Function and Pathology
- Ion channel regulation and function
- Drug Transport and Resistance Mechanisms
- RNA Interference and Gene Delivery
- Pesticide Exposure and Toxicity
- Paraquat toxicity studies and treatments
- Heavy Metal Exposure and Toxicity
- Alzheimer's disease research and treatments
- Endoplasmic Reticulum Stress and Disease
- Cell death mechanisms and regulation
- Free Radicals and Antioxidants
- Metabolomics and Mass Spectrometry Studies
- Metabolism, Diabetes, and Cancer
University of Nebraska–Lincoln
2016-2025
University of Nebraska Medical Center
2016
Redox (Norway)
2012-2013
National Institutes of Health
2006-2010
National Institute of Environmental Health Sciences
2006-2009
Ames National Laboratory
2007
Universidad Nacional Autónoma de México
2000-2006
Institute of Cell Biology
2000
CNS Research (United States)
1998
Illinois State University
1995
Changes in the intracellular redox environment of cells have been reported to be critical for activation apoptotic enzymes and progression programmed cell death. Glutathione (GSH) depletion is an early hallmark observed apoptosis, we demonstrated that GSH efflux during death receptor-mediated apoptosis occurs via a transporter. We now evaluate relationship between depletion, generation reactive oxygen species (ROS), apoptosis. Simultaneous single analysis changes content ROS formation by...
The tripeptide hypothalamic releasing factor, thyrotropin-releasing hormone (TRH), rapidly increases prolactin gene transcription 7- to 12-fold in the GH4 rat pituitary cell line. maximal rates of are achieved within minutes and begin attenuate 1 h following addition TRH. This transcriptional response appears account for observed effects TRH on accumulation mRNA stimulation biosynthesis. rapid include a large number polymerase II-catalyzed units. Addition cultures also induces...