A5100683347- Ubiquitin and proteasome pathways
- Epigenetics and DNA Methylation
- Cancer-related gene regulation
- Hippo pathway signaling and YAP/TAZ
- RNA Research and Splicing
- Wnt/β-catenin signaling in development and cancer
- Immunotherapy and Immune Responses
- Bone and Dental Protein Studies
- Cancer-related Molecular Pathways
- Redox biology and oxidative stress
- Natural product bioactivities and synthesis
- Histone Deacetylase Inhibitors Research
- RNA Interference and Gene Delivery
- melanin and skin pigmentation
- Plant Molecular Biology Research
- Galectins and Cancer Biology
- RNA modifications and cancer
- Marine and Offshore Engineering Studies
- Carbohydrate Chemistry and Synthesis
- MicroRNA in disease regulation
- Ombudsman and Human Rights
- Liver physiology and pathology
- Glutathione Transferases and Polymorphisms
- Nuclear Structure and Function
- Plant responses to water stress
Fudan University
2007-2025
Inner Mongolia University of Science and Technology
2024
Dalian Medical University
2024
Second Affiliated Hospital of Dalian Medical University
2024
State Key Laboratory of Genetic Engineering
2023
Zhejiang University
2023
Children's Hospital of Zhejiang University
2023
China Agricultural University
2015-2021
Harbin Medical University
2021
Third Affiliated Hospital of Harbin Medical University
2021
To investigate the prognostic value of tumor-infiltrating lymphocytes (TILs), especially regulatory T cells (Tregs), in hepatocellular carcinoma (HCC) patients after resection.CD3+, CD4+, CD8+, Foxp3-positive, and granzyme B-positive TILs were assessed by immunohistochemistry tissue microarrays containing HCC from 302 patients. Prognostic effects low- or high-density TIL subsets evaluated Cox regression Kaplan-Meier analysis using median values as cutoff.CD3+, CD8+ associated with neither...
Human chronic cholestatic liver diseases are characterized by cholangiocyte proliferation, hepatocyte injury, and fibrosis. Yes-associated protein (YAP), the effector of Hippo tumor-suppressor pathway, has been shown to play a critical role in promoting proliferation survival during embryonic development hepatocellular carcinogenesis. Therefore, aim this study was examine whether YAP participates regenerative response after injury. First, we examined human tissue from patients with...
Previous studies have shown that Ogt-mediated O-GlcNAcylation is essential for neuronal development and function. However, the function of O-GlcNAc transferase (Ogt) in astrocytes remains largely unknown. Here we show Ogt deficiency induces inflammatory activation vivo vitro, impairs cognitive mice. The restoration via GlcNAc supplementation inhibits astrocytes, inflammation improves impaired deficient Mechanistically, interacts with NF-κB p65 catalyzes astrocytes. signaling pathway by...
Studies indicate that blue light (BL) irradiation can damage human skins, but the impact of BL on skin aging is unknown.This study aimed to give an insight phenotypic characteristics and molecular mechanism light-induced aging, thus provide a theoretical basis for precise protection photodermatosis.The effect photoaging in mice was evaluated by non-invasive measurement equipment histopathology analysis. The proliferation HFF-1 cells detected Real-Time Cell Analyzer. expression protein levels...
Artocarpus heterophyllus is an evergreen fruit tree cultivated in many tropical regions. Previous studies have shown that some of its compositions exhibited potential tyrosinase inhibition activities. This study indentified 8 new phenolic compounds, artoheterophyllins E-J (1-6), 4-geranyl-2',3,4',5-tetrahydroxy-cis-stilbene (7), and 5-methoxymorican M (8) 2 natural compounds (9 10), 2,3-dihydro-5,7-dihydroxy-2-(2-hydroxy-4-methoxyphenyl)-4H-benzopyran-4-one...
// Huanan Wang 1, 2, 4, * , Lingling Zhang 3, Xu Yang Yipeng Jin Shimin Pei 1 Di Hong Bin Zhou Yingjie ** Degui Lin The Clinical Department, College of Veterinary Medicine, China Agricultural University, Beijing, 2 Department Molecular State Key Laboratory Chemo/Biosensing and Chemometrics, Biology, Hunan Changsha, 3 Chinese University Kong, Shatin, New Territories, 4 Animal Sciences, Zhejiang Hangzhou, These authors have contributed equally as first last Correspondence to: Zhang, e-mail:...
Small nucleolar RNAs may serve as new potential biomarkers for the diagnosis and treatment of liver cancer. The purpose our study was to reveal mechanism small RNA 42 (SNORA42) affects proliferation migration cancer cells. Quantitative real-time PCR (qRT-PCR) performed detect expression SNORA42 its host gene. Cell were measured using CCK-8 Transwell assays, respectively. Western blotting measure proteins affected by SNORA42. overexpression could reinforce hepatocellular carcinoma (HCC)...
Lung cancer, similar to other chronic diseases, occurs due perturbations in multiple signaling pathways. Mono-targeted therapies are not ideal since they likely be effective for the treatment and prevention of lung often associated with drug resistance. Therefore, development multi-targeted agents is required novel cancer therapies. Thioredoxin reductase (TrxR or TXNRD1) a pivotal component thioredoxin (Trx) system. Various types tumor cells able overexpress TrxR/Trx proteins order maintain...
Abstract Gastric cancer remains the third leading cause of cancer-related death, and tumor metastasis is main risk factor for poor prognosis patients with gastric cancer. Transcription EB (TFEB) a MiT family member has been found to drive tumorigenesis in number tissues, whereas few studies were focused on investigating its prometastasis role mechanism Here, we TFEB was upregulated tissues compared adjacent normal epithelial tissues. IHC analysis from tissue microarray revealed that...
Hepatocellular carcinoma (HCC) is one of the most common lethal human malignancies worldwide. Sorafenib first-line drug approved by United States Food and Drug Administration for HCC. However, acquired resistance to sorafenib reduces its beneficial effects limits clinical use. In this study, we established a sorafenib-resistant HCC cell line HepG2-SR low-concentration gradient induction. Compared with parental HepG2, proliferation anti-apoptosis were increased in drug-resistant HepG2-SR....
The aldo-keto reductase (AKR) superfamily of enzymes is critical for the detoxification drugs and toxins in human body; these are involved not only development drug resistance cancer cells but also metabolism polycyclic aromatic hydrocarbons. Here, we demonstrated that AKR1C1/C2 increased ethyl-3,4-dihydroxybenzoate (EDHB) esophageal squamous cell carcinoma (ESCC) cells. Previous studies have shown EDHB can effectively induce autophagy apoptosis, AKR1C family represents one set highly...
Spinal cord injury (SCI) often results in motor disability concomitant with limit neuroplasticity; the underlying mechanism, however, is still unclear. This study established spinal transection rats model (T10), then performed cDNA microarray analysis and found that vimentin located astrocytes was increased significantly scar tissues after transection. To understand role of it's mechanism regulation, RNA interference luciferase assay were used. Vimentin knockdown showed a significant...
Abstract Dentinogenesis is the formation of dentin, a substance that forms majority teeth and this process performed by odontoblasts. Dental papilla cells (DPCs), as progenitor odontoblasts, undergo odontogenic differentiation regulated multiple cytokines paracrine signal molecules. Ape1 perfect paradigm function complexity biological macromolecule with two major functional regions for DNA repair redox regulation, respectively. To date, it remains unclear whether can regulate dentinogenesis...
Bone loss is caused by occlusal hypofunction and a serious health concern. This particularly true of tooth loss, which common in the elderly. However, cellular molecular mechanisms underlying bone have yet to be fully elucidated. Sclerostin Wnt/β‑catenin signaling previously been reported serve important roles regulating remodeling. Therefore, present study aimed investigate involvement sclerostin hypofunction‑induced alveolar The unilateral maxillary molars 14 male Sprague‑Dawley rats were...
The use of cyclosporine A (CsA) in transplant recipients is limited due to its side effects causing severe hypertension. We have previously shown that CsA increases the activity epithelial sodium channel (ENaC) cultured distal nephron cells. However, it remains unknown whether ENaC mediates CsA-induced hypertension and how we could prevent Our data show open probability principal cells split-open cortical collecting ducts was significantly increased after treatment rats with CsA; increase...
Colorectal cancer (CRC) is one of the most common malignant tumors globally, with metastasis emerging as leading cause mortality in CRC patients. Transcription factors play pivotal roles metastatic process. Using bioinformatics tools, we analyzed TCGA-COAD and GES146587 datasets identified ZNF248 participating tumor progression. By analyzing 100 patient tissues, it found that highly expressed tissue well cell lines by qRT-PCR. Our study discovered enhances migratory invasive capabilities. A...