A5101902586- RNA modifications and cancer
- Cancer-related gene regulation
- Esophageal Cancer Research and Treatment
- Epigenetics and DNA Methylation
- TGF-β signaling in diseases
- Ubiquitin and proteasome pathways
- Cancer-related molecular mechanisms research
- Ovarian function and disorders
- Microbial Metabolism and Applications
- Insect and Pesticide Research
- Sarcoma Diagnosis and Treatment
- Bacterial biofilms and quorum sensing
- Reproductive System and Pregnancy
- Ferroptosis and cancer prognosis
- Gastric Cancer Management and Outcomes
- Apelin-related biomedical research
- Antibiotic Resistance in Bacteria
- Microbial Natural Products and Biosynthesis
- Pediatric health and respiratory diseases
- Circular RNAs in diseases
- Galectins and Cancer Biology
- interferon and immune responses
- Gastrointestinal Bleeding Diagnosis and Treatment
- Analytical Chemistry and Chromatography
- Legionella and Acanthamoeba research
Jiaxing University
2022-2025
Daping Hospital
2025
Army Medical University
2025
Shanghai Children's Medical Center
2023-2024
Shanghai Jiao Tong University
2024
First Hospital of Jiaxing
2024
Baogang Group (China)
2024
Tianjin Medical University General Hospital
2024
Nankai University
2023
Huizhou University
2023
Twelve subjects were treated with zidovudine, lamivudine, and ritonavir within 90 days of onset symptoms acute infection to determine whether human immunodeficiency virus type 1 (HIV-1) could be eradicated from an infected host. In adherent subjects, or without modifications due intolerance, viral replication was suppressed during the 24-month treatment period. Durable suppression reduced levels HIV-1—specific antibodies cytotoxic T lymphocyte responses in selected subjects. Proviral DNA...
Circular RNAs (circRNAs) play crucial roles in the development and progression of human cancers, including non-small cell lung cancer (NSCLC). However, most these circRNAs, such as hsa_circ_0014235, are not fully identified functions mechanisms.The isolated exosomes from serum specimens were using transmission electron microscopy (TEM). The expression miR-520a-5p cyclin-dependent kinase 4 (CDK4) was detected by real-time quantitative polymerase chain reaction (qPCR). For functional assays,...
Significance This paper demonstrates that aminoglycoside antibiotics induce the production of Ap4A in bacteria. Increased intracellular Ap4A, turn, promotes bacterial cell killing by this class antibiotics, which correlated well with elevated damage to membrane upon treatment. These findings reveal a striking connection between and particularly under conditions oxidative stress. Importantly, results study suggest targeting degradation or inducing its hypersynthesis during therapy...
Background & Aims: Autoimmune gastritis (AIG), distinct from Helicobacter pylori-associated atrophic (HpAG), is underdiagnosed due to limited awareness. This multicenter study aims develop a novel endoscopic artificial intelligence (AI) system assisting in AIG diagnosis. Methods: Patients diagnosed with AIG, as well HpAG and non-atrophic (NAG), were retrospectively enrolled six centers. Endoscopic images relevant demographic medical data, collected for the development of AI-assisted...
Coenzyme Q10 (CoQ10), an important fat-soluble, bioactive molecule that predominantly found in the inner mitochondrial membrane, is widely used functional food and health raw materials, which has garnered considerable attention due to its potential role immunoregulation. However, intrinsic mechanism of CoQ10 on immunity, relationship gut microbiota have not been elucidated. Here, we conducted a series vivo experiments with aim comprehensively exploring effect both cellular humoral immune...
Receptor for advanced glycation end products (RAGE) is associated with the pathogenesis of cancer progression. The pathological effects mediated through RAGE are physiologically inhibited by soluble (sRAGE). aim present study was to identify expression sRAGE, and ligands in serum samples lung tissue obtained from patients. Using ELISA immunohistochemistry, it observed that sRAGE levels were downregulated serum, decreased HMGB1 S100 upregulated tissue. Furthermore, presence several selected...
Three-dimensional quantitative structure-activity relationship (3D-QSAR) is one of the most important and effective tools to direct molecular design in new pesticide development. Chlorantraniliprole an anthranilic diamide ryanodine receptor (RyR) agonist with ultrahigh activity, high selectivity, mammalian safety. To continue our studies on insecticide development, here, we designed insecticidal N-phenylpyrazoles by using 3D-QSAR chlorantraniliprole analogues as a guide. Most target...
Background: The lung cancer staging system is insufficient for a comprehensive evaluation of patient prognosis. We constructed novel immunoscore model to predict patients with high risk and poor survival. Method: Immunoscore was developed based on z-score transformed enrichment score 11 immune-related gene sets 109 immune genes. trained in adenocarcinoma cohort from Cancer Genome Atlas (TCGA-LUAD) (n = 400), validated other two independent cohorts Gene Expression Omnibus (GEO), GSE31210 219)...
In animals ranging from fish to mice, the function of DACT2 as a negative regulator TGF-β/Nodal signal pathway is conserved in evolution, indicating that it might play an important role human cancer. this study, we showed tumors with higher protein level were correlated better differentiation and survival rate patients esophageal squamous cell carcinoma. Restored expression significantly inhibited growth, migration, invasion ESCC cells vitro, reduced tumorigenicity vivo. Furthermore, when...
To investigate the effect of Lactobacillus rhamnosus GR-1 on atherosclerotic progression in apolipoprotein-E knockout (ApoE-/-) mice fed with a high-fat diet and underlying mechanisms its action.Eight-week-old ApoE-/- were treated daily for 12 weeks. vehicle group wild type (WT) normal saline. Serum lipid levels, histopathological analysis aorta, oxidative inflammatory indexes activation nuclear factor-kappa B (NF-κB) signaling pathway examined.Compared to group, no changes body weight or...
The dinucleotide alarmone diadenosine tetraphosphate (Ap4A), which is found in cells, has been shown to affect the survival of bacteria under stress.