A5090693366- MicroRNA in disease regulation
- Circular RNAs in diseases
- Cancer-related molecular mechanisms research
- Spinal Cord Injury Research
- Nerve injury and regeneration
- RNA modifications and cancer
- Inflammasome and immune disorders
- Adenosine and Purinergic Signaling
- Diet, Metabolism, and Disease
- Cancer, Stress, Anesthesia, and Immune Response
- Nitric Oxide and Endothelin Effects
- Phytochemicals and Antioxidant Activities
- Polyamine Metabolism and Applications
- Extracellular vesicles in disease
- Urinary Bladder and Prostate Research
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Postharvest Quality and Shelf Life Management
- Natural product bioactivities and synthesis
- Epigenetics and DNA Methylation
- RNA and protein synthesis mechanisms
- Immune cells in cancer
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Neurogenesis and neuroplasticity mechanisms
- ATP Synthase and ATPases Research
- Neuroscience and Neuropharmacology Research
Chongqing Medical University
2017-2025
Second Affiliated Hospital of Jilin University
2025
Hezhou University
2022-2024
Henan Provincial People's Hospital
2024
Institute of Food Science and Technology
2024
Yale University
2023
Bengbu Medical College
2023
Women's Aid Organisation
2019
Thermo Fisher Scientific (Japan)
2019
West China Hospital of Sichuan University
2014-2017
The ketogenic diet (KD) has been widely used in clinical studies and shown to hace an anti-diabetic effect, but the underlying mechanisms have not fully elaborated. Our aim was investigate effects underling of KD on cardiac function db/db mice. In present study, mice were subjected a normal (ND) or KD. Fasting blood glucose, morphology, mitochondrial dynamics, oxidative stress, apoptosis measured 8 weeks post treatment. Compared with ND, improved glycemic control protected against diabetic...
Abstract Background The association between lipid and bone metabolism, particularly the role of high-density lipoprotein cholesterol (HDL-C) in regulating mineral density (BMD), is significant interest. Despite numerous studies, findings on this relationship remain inconclusive, especially since evidence from large, sexually diverse Chinese populations sparse. This study, therefore, investigates correlation HDL-C lumbar BMD people different genders using extensive population-based data...
ATP, released from urothelial cells, modulates afferent nerve firing the urinary bladder. Here, we have characterized ATP release rat bladder mucosa in response to acid, capsaicin, electrical field stimulation (EFS) and stretch, using agonists antagonists at transient receptor potential vanilloid 1 (TRPV1) acid-sensing ion channels (ASICs).Rat mucosal strips (containing urothelium lamina propria) Perspex microbaths were superfused with Krebs solution. was measured after exposure of matched...
Daucosterol, a natural saponin from Eleocharis dulcis peel, exhibited anti-hyperglycemic properties. This study investigated daucosterol's effects on glycemic control, insulin resistance, and gut microbiota in type 2 diabetic mice. The results demonstrated that daucosterol treatment reduced fasting glucose, improved glucose intolerance pancreatic islet damage. It decreased HOMA-IR increased ISI, indicating enhanced sensitivity. Daucosterol supplementation enriched diversity, including...
Microglia M1 polarization plays important role in the development of ischemic stroke (IS). This study explored transcription factor 7 like 2 (TCF7L2) regulating microglia during IS. TTC staining was used to determine cerebral infarction, and Nissl applied examine neuronal injury. The secretion levels cytokines were measured using ELISA. interaction between Zinc finger E-Box binding homeobox (ZEB2) TCF7L2 analyzed by Co-IP, H3K27ac enrichment promoter detected ChIP assay. knockdown reduced...
This study investigated the role of integrin-linked kinase (ILK) in neuronal apoptosis induced by cerebral ischemia‒reperfusion injury (CIRI) and its interaction with a circRNA (0000964) miR-758-3p. Using vivo vitro rat models, we clarified how ILK regulates during CIRI. Our findings revealed that expression is upregulated response to CIRI modulated (0000964)/miR-758-3p axis. provides new insights into molecular mechanisms suggests potential therapeutic targets reduce apoptosis. A model was...
Abstract Neuroregeneration and apoptosis are two important pathophysiologic changes after spinal cord injury (SCI), but their underlying mechanisms remain unclear. MicroRNAs (miRNAs) play a crucial role in the regulation of neuroregeneration neuronal apoptosis, research areas that have been greatly expanded recent years. Here, using miRNA arrays to profile transcriptomes, we demonstrated miR-127-3p was significantly down-regulated transection (SCT). Then, bioinformatics analyses experimental...
Background: Sterile inflammation contributes to the pathogenesis of cardiac dysfunction caused by various conditions including pressure overload in hypertension.Mitochondrial DNA (mtDNA) released from damaged mitochondria has been implicated inflammation.However, upstream mechanisms governing mtDNA release and how activates sterile pressure-overloaded hearts remain largely unknown.Here, we investigated role inducible NO synthase (iNOS) on overload-induced cytosolic accumulation whether...
Progesterone exerts antihypertensive actions partially by modulating endothelial nitric oxide synthase (eNOS) activity. Here, we aimed to investigate the effects and mechanisms of progesterone on eNOS expression. First, human umbilical vein cells (HUVECs) were exposed then transcription factor specificity protein-1 (SP-1) receptor (PRA/B) expression assessed Western blotting qRT-PCR. The interaction between SP-1 PRA/B was next determined through coimmunoprecipitation assay. chromatin...
Pulmonary arterial hypertension (PAH) is an incurable disease with high mortality. Chemerin has been found to be associated pulmonary (PH). However, the specific role of chemerin in mediating PH development remains unclear. This study aimed elucidate regulatory effects and underlying mechanism on investigate expression levels protein plasma PAH patients.
Abstract Patients with tumors that metastasize to bone frequently suffer from debilitating pain, and effective therapies for treating cancer are lacking. This study employed a novel strategy in which herpes simplex virus (HSV) carrying small interfering RNA (siRNA) targeting platelet-derived growth factor (PDGF) was used alleviate pain. HSV PDGF siRNA established intrathecally injected into the cavum subarachnoidale of animals suffering pain negative group. Sensory function assessed by...
Circular RNAs (circRNAs) are generated by head-to-tail splicing and ubiquitously expressed in all multicellular organisms. Their important biological functions increasingly recognized. Cerebral ischemia reperfusion injury-induced brain microvascular endothelial cell dysfunction is an initial stage of blood-brain barrier disruption. The expression profile potential function circRNAs cells unknown. Rat were extracted cultured glucose-free medium for 4 hours with 5% CO2 95% N2, the was then...
Myocardial fibrosis (MF) is a pathological process that accelerates cardiac remodeling in myocardial infarction (MI), and miR-29 has become one of the foci research into MF. As an alkaloid extracted from Herba leonuri, leonurine (LE) been found to be effective natural active ingredient for inhibiting many preclinical experiments. However, whether LE protects against MF after MI through modifying remains unclear. The present study aimed investigate therapeutic effects on MF, elucidate...
The tsRNAs (tRNA-derived small RNAs) are new types of noncoding RNAs derived from tRNAs. Gliomas well-known malignant brain tumors. study focused on tsRNA characterizations within gliomas. Datasets processing, bioinformatics analyses, and visualizations were performed with the packages Python R. Cell proliferations demonstrated via CCK8 assays colony formation assays, in vivo xenograft experiments. Dual-luciferase reporter assay was to confirm binding its targets. Via using approaches,...
Spinal cord injury (SCI) often results in motor disability concomitant with limit neuroplasticity; the underlying mechanism, however, is still unclear. This study established spinal transection rats model (T10), then performed cDNA microarray analysis and found that vimentin located astrocytes was increased significantly scar tissues after transection. To understand role of it's mechanism regulation, RNA interference luciferase assay were used. Vimentin knockdown showed a significant...