High expression of cell division cycle 20 homolog (CDC20), a key component the spindle assembly checkpoint (SAC), has been reported in various malignancies and plays vital role tumorigenesis progression. The goal this study was to evaluate utility CDC20 immunostaining wide range malignant tumors. immunohistochemistry evaluated normal tissues compared most frequently occurring tumors these (bladder, breast, cervical, colonic, endometrial, gastric, head neck, liver, lung, ovarian, pancreatic,...

The Hippo (Hpo) pathway is highly conserved in humans and was originally uncovered Drosophila as a potent regulator of inhibiting cell growth promoting apoptosis. consists tumor suppressor kinase cascade that negatively regulates results inactivation transcriptional co-activator, Yorkie (yki). human ortholog Yki, the yes-associated protein (YAP), has 31% sequence identity similar biologic activity. potential role YAP tumorigenesis also reported murine genetic screen which identified genomic...

c-MET plays an important role in tumor proliferation, invasion and metastasis. In this study we examined the expression of colorectal adenomas, primary adenocarcinomas their corresponding lymph node, peritoneal liver metastases. We correlated our findings with clinicopathological features.Twenty three cases adenoma 102 carcinoma metastases (44 nodes, 21 deposits 16 metastases) were studied to evaluate by immunohistochemistry. For comparison, 12 sections adjacent healthy mucosa...

Chemerin was reported to regulate adipogenesis, metabolism, and immunity. But, its relation cancer remains controversial. In breast cancer, chemerin expression has only been studied in serum, however, tissue, our knowledge, not studied. The aim of this study investigate tissue comparison the adjacent normal assess relationship disease prognosis.We examined with immunohistochemistry analyzed association patients' clinical pathological characteristics determine role as a predictor detected...

Sepsis is one of the most common causes death among hospitalized patients. Activity xanthine oxidase (XO), a reactive oxygen species-producing enzyme, known to be elevated in septic Our aim was investigate possible protective role XO inhibitor, febuxostat (FEB), rat model sepsis-induced liver and kidney injures. Adult male albino rats were divided into four groups ( n = 12 each): sham control, + FEB, cecal ligation puncture (CLP), CLP FEB groups. (10 mg/kg per os (p.o.)) given once daily for...

Abstract Lung cancer is considered the major cause of cancer-related deaths worldwide. Unfortunately, all chemotherapy regimens used in lung treatment showed nearly same efficacy. Finding a new therapeutic target that can be as an alternative after failure or association with to improve prognosis urgent demand. Up date, it Known thyroid hormones (THs) and Thyroid hormone receptors (THRs) control progression several types tumours. Nevertheless, their role non-small cell (NSCLC) unknown. This...

Although it has been reported that NUSAP1 and GTSE1 are highly expressed in different types of tumors associated with malignant progression poor clinical prognosis, their significances clinicopathological data correlations patients' survival ccRCC still poorly understood. Therefore, our study we attempted to evaluate the link between correlate immunoexpression clinico-pathological parameters identify significance as potential therapeutic targets, indicators for tumor progression, prognosis.

Stress disturbs homeostasis and may induce various disorders. Immobilization stress (IS) induced due to reduced area provided for mobility results in the imbalance of oxidant antioxidant status. leads male reproductive dysfunction many species, including rodents humans. Induction heme oxygenase-1 (HO-1), rate limiting enzyme degradation, increases host defenses. We elucidated protective role induction HO-1 by hemin on testicular damage acute IS.Male albino rats were immobilized a period 6 h....

Paraphenylene-diamine (PPD) is a widely used chemical in almost all hair dye formulations. The main purpose of using PPD as ingredients to fasten the process dyeing compared traditional henna. Since mammalian contact with these via scalp for cosmetic applications such dyes current study was designed investigate potency induce toxic effects upon liver, kidney, heart and pancreas after 30 days continuous daily dermal application three different dosages 1, 2, 3 mg/kg adult male Albino rats, 10...

The aim of this study was to investigate the expression SOX2, a key transcription factor and livin, an apoptotic inhibitor in bladder transitional cell carcinoma (TCC) squamous (SCC). Moreover, their prognostic significance assessed.The expressions SOX2 livin 82 TCC 35 SCC cases were detected by immunohistochemistry.SOX2 over-expressed tumor tissues as compared corresponding adjacent non-neoplastic tissues. significantly associated with high grade (P = 0.002 P 0.007, respectively) stage...

Endometrial carcinoma (EC) is the second most frequent malignant tumor of female reproductive system in Egypt. In recent years, incidence and deaths EC have been increased. SLCO4C1 found to a role various tumors such as head neck, renal, ovarian prostate cancer. EC, it controls endometrial cancer cells' migration, apoptosis, proliferation, other traits. This study's objective was investigate expression prognostic lesions. The immunohistochemical examined 20 cases atypical...

Background: Colorectal Cancer (CRC) accounts for a widely occurring malignant neoplasm originating from the colon or rectum. It is considered second most common contributor to cancer-related death. PDL1 plays an important function in immune response, serving as vital component bolstering body's system against tumor cells. The utilization of medications inhibiting PD1/PDL1 pathway strengthens and induce lysis cells, therefore presenting novel avenue treatment cancer. Aim work: This study was...

Introduction: Globally, renal cell carcinoma (RCC) is among the most prevalent malignancies. A mixture of genetic mutations and environmental influences are main causes. NUSAP1 an anti-apoptotic marker which enhances cellular invasion migration via a variety pathways, including PI3K/AKT/mTOR pathway. has been shown to be significantly expressed in tumours, but little known about its implications ccRCC. Aim work: assess IHC expressions investigate relationship between expression various...

Liver fibrosis affects progression of fatty liver. Epidemiological data about in overweight/obese Egyptian patients undergoing bariatric surgery are limited. We aimed to assess hepatic steatosis and with metabolic associated liver disease (MAFLD) before via noninvasive tools biopsy. A cross-sectional study MAFLD the Hepatogastroenterology Hospital was performed. For all recruited cases, history taken clinical examination, laboratory testing, intra-operative laparoscopic biopsies...

ENWEndNote BIBJabRef, Mendeley RISPapers, Reference Manager, RefWorks, Zotero AMA Gayyed M, Soliman El-Hussieny M. Clinical utility of MCM2 and CD44 expression in clear cell renal carcinoma. Polish Journal Pathology. 2020;71(4):339-346. doi:10.5114/pjp.2020.103714. APA Gayyed, M., Soliman, & El-Hussieny, (2020). Pathology, 71(4), 339-346. https://doi.org/10.5114/pjp.2020.103714 Chicago Mariana F., Medhat Maram El-Hussieny. 2020. "Clinical carcinoma". Pathology 71 (4): Harvard pp.339-346. MLA...

ENWEndNote BIBJabRef, Mendeley RISPapers, Reference Manager, RefWorks, Zotero AMA F. Gayyed M, Monir Soliman Fouad Ahmed Mohamed Hassanin T, Munir Al Jehani R, Zahraa Ammar Activation of the P38-MSK1 axis in colorectal adenocarcinoma determines a good prognostic outcome. Polish Journal Pathology. 2021;72(1):39-47. doi:10.5114/pjp.2021.106442. APA Gayyed, M., Soliman, Ahmed, Hassanin, T., Jehani, R., & Mohamed, (2021). Pathology, 72(1), 39-47. https://doi.org/10.5114/pjp.2021.106442 Chicago...

Sarcomas are a heterogeneous group of malignant tumors that arise from mesenchymal cells and can anywhere in the body, whether it is soft tissue or bone. Epidermal growth factor receptor (EGFR) expression pediatric sarcomas explored current study. A key feature EGFRs their general involvement signal transduction oncogenesis, making them one most studied protein-tyrosine kinase families. The study included 104 archived formalin-fixed paraffin-embedded blocks assessed using immunohistochemical...

Background: Breast carcinoma is the most common cancer in Egyptian women.Developing metastasis leading cause of death patients with invasive ductal breast.The epithelial-mesenchymal transition (EMT) plays an important role breast metastasis.Snail 1 a key regulator EMT tumor cells.Aim: To study immunohistochemical expression Snail NOS and their association different clinicopathological features IDC.Material methods: This comprised 70 cases IDC-NOS breast.Formalin fixed paraffin-embedded...