A5070743401- Adipose Tissue and Metabolism
- Anesthesia and Neurotoxicity Research
- Healthcare Systems and Reforms
- Dialysis and Renal Disease Management
- Acute Kidney Injury Research
- Cancer, Hypoxia, and Metabolism
- Pancreatic function and diabetes
- Lipid metabolism and biosynthesis
- Chronic Kidney Disease and Diabetes
- Cardiac Ischemia and Reperfusion
- Machine Learning in Healthcare
- Adipokines, Inflammation, and Metabolic Diseases
- Healthcare Policy and Management
- Intensive Care Unit Cognitive Disorders
- Anesthesia and Sedative Agents
- Artificial Intelligence in Healthcare
- Reproductive Biology and Fertility
- Chemotherapy-induced organ toxicity mitigation
- International Development and Aid
- Mesenchymal stem cell research
- Discourse Analysis and Cultural Communication
- Neurological Complications and Syndromes
- Pluripotent Stem Cells Research
- Cytomegalovirus and herpesvirus research
- Esophageal Cancer Research and Treatment
First Affiliated Hospital Zhejiang University
2020-2024
Model Animal Research Center
2024
Nanjing University
2024
Peking University First Hospital
2015-2024
Peking University
2014-2024
University Hospital Bonn
2024
University of Bonn
2024
Inserm
2016-2023
Université Côte d'Azur
2016-2023
Centre National de la Recherche Scientifique
2016-2023
Intestinal ischemia-reperfusion (I/R) injury is a devastating complication in the perioperative period. Dexmedetomidine commonly applied The authors aimed to determine effects of different doses dexmedetomidine (given before or after intestinal ischemia) on I/R and explore underlying mechanisms.Intestinal was produced rat by clamping superior mesenteric artery for 1 h followed 2 reperfusion. Intravenous infusion performed at 2.5, 5, 10 μg · kg(-1) h(-1) ischemic insult. In addition,...
Remote ischemic preconditioning (RIPC) may confer the cytoprotection in critical organs. The authors hypothesized that limb RIPC would reduce intestinal and pulmonary injury patients undergoing open infrarenal abdominal aortic aneurysm repair.In this single-center, prospective, double-blinded, randomized, parallel-controlled trial, 62 elective repair were randomly assigned a 1:1 ratio by computerized block randomization to receive or conventional (control). Three cycles of 5-min...
Abstract Brown adipose tissue (BAT) is a central thermogenic organ that enhances energy expenditure and cardiometabolic health. However, regulators specifically increase the number of adipocytes are still an unmet need. Here, we show cAMP-binding protein EPAC1 regulator adaptive BAT growth. In vivo, selective pharmacological activation increases mass browning white fat, leading to higher reduced diet-induced obesity. Mechanistically, coordinates network for proliferation in adipocytes, but...
Background: Cisplatin is a widely used anti-tumor agent but its use frequently limited by nephrotoxicity.Transient receptor potential melastatin 2 (TRPM2) non-selective cation channel which generally viewed as sensor of oxidative stress, and increasing evidence supports link with autophagy, critical process for organelle homeostasis.Methods: Cisplatin-induced cell injury mitochondrial damage were both assessed in WT Trpm2-knockout mice primary cells.RNA sequencing, immunofluorescence...
Abstract Human induced pluripotent stem cells (hiPSCs) show great promise for obesity treatment as they represent an unlimited source of brown/brite adipose progenitors (BAPs). However, hiPSC-BAPs display a low adipogenic capacity compared to adult-BAPs when maintained in traditional cocktail. The reasons this feature are unknown and hamper their use both cell-based therapy basic research. Here we that with TGFβ pathway inhibitor SB431542 together ascorbic acid EGF were required promote...
Genome-wide association studies have reported that DNA polymorphisms at the CDKN2A locus modulate fasting glucose in human and contribute to type 2 diabetes (T2D) risk. Yet causal relationship between this gene defective energy homeostasis remains elusive. Here we sought understand contribution of Cdkn2a metabolic homeostasis. We first analyzed from Cdkn2a-deficient mice subjected normal or high fat diets. Subsequently primary adipose cells human-induced pluripotent stem differentiated into...
Abstract Obesity and type 2 diabetes are becoming a global sociobiomedical burden. Beige adipocytes emerging as key inducible actors putative relevant therapeutic targets for improving metabolic health. However, in vitro models of human beige adipose tissue currently lacking hinder research into this cell biotherapy development. Unlike traditional bottom‐up engineering approaches that aim to generate building blocks, here scalable system is proposed pre‐vascularized functional organoids...
Abstract Background Cancer cells cooperate with that compose their environment to promote tumor growth and invasion. Among them, adipocytes provide lipids used as a source of energy by cancer adipokines contribute expansion. Mechanisms supporting the dynamic interactions between stromal adipocytes, however, remain unclear. Methods We set-up co-culture model breast grown in 3D mammospheres human accurately recapitulate intrinsic features tumors, such hypoxia cell–adipocytes interactions....
Beginning in 2010, China has endeavoured to expand health coverage and provide residents with fair access primary care the intention of improving equity. This study aims measure changes income-related inequity between 2010 2014. Data were extracted from nationally representative annual survey Family Panel Studies 2014 a first wave 31,743 respondents second 32,006 over age 15. In both years, subjects stratified into following five categories income: poorest 20%, lower medium higher 20%...
Abstract Background Numerous studies have addressed lymphovascular invasion (LVI) in patients with thoracic oesophageal squamous cell carcinoma (ESCC); however, little is known about the individual roles of lymphatic (LI) and vascular (VI). We aimed to analyse prognostic significance LI VI ESCC from a single centre. Methods This retrospective study included 396 who underwent oesophagectomy lymphadenectomy our hospital. The relationship between LI, other clinical features was analysed,...
Autologous fat grafting is a gold standard therapy for soft tissue defects, but hampered by unpredictable postoperative outcomes. Fat graft enrichment with adipose-derived stromal cell (ASCs) was recently reported to enhance survival. Platelet-rich plasma (PRP) has also emerged as biologic scaffold that promotes viability. Combined ASC/PRP thus promising new regenerative medicine approach. The effects of PRP on ASC proliferation are well documented, the impact differentiation yet be...
Abstract Background There are conflicting research results about the survival differences between hemodialysis(HD) and peritoneal dialysis (PD). The present study estimated relative mortality hazard for incident HD PD patients with end stage renal disease (ESRD) in eastern China. Methods This examined a cohort of ESRD who initiated therapy Zhejiang province Jan 2010 Dec 2014, followed up until 2015. were matched 1:1 fashion patients, Kaplan–Meier analysis was used to explore them. Cox...
Demethylase Tet2 plays a vital role in the immune response. Acute kidney injury (AKI) initiation and maintenance phases are marked by inflammatory responses leukocyte recruitment endothelial tubular cell processes. However, of AKI is poorly defined. Our study determined degree renal tissue damage associated with gene expression levels cisplatin-induced mice model. Tet2-knockout (KO) cisplatin treatment experienced severe necrosis dilatation, inflammation, markers' than wild-type mice. In...