A5067749238- Liver Disease Diagnosis and Treatment
- Adipose Tissue and Metabolism
- PI3K/AKT/mTOR signaling in cancer
- Adipokines, Inflammation, and Metabolic Diseases
- Liver physiology and pathology
- Cardiovascular Disease and Adiposity
- Metabolism, Diabetes, and Cancer
- Cancer, Lipids, and Metabolism
- Muscle metabolism and nutrition
- Fatty Acid Research and Health
- Exercise and Physiological Responses
- Hepatitis C virus research
- Lipid metabolism and biosynthesis
- Epigenetics and DNA Methylation
- Hepatocellular Carcinoma Treatment and Prognosis
- Peroxisome Proliferator-Activated Receptors
- Mesenchymal stem cell research
- Growth Hormone and Insulin-like Growth Factors
- Tissue Engineering and Regenerative Medicine
- RNA modifications and cancer
- MicroRNA in disease regulation
- Ferroptosis and cancer prognosis
- Amino Acid Enzymes and Metabolism
- Retinoids in leukemia and cellular processes
- Lipid metabolism and disorders
Institute for Research in Biomedicine
2016-2024
Universitat de Barcelona
2010-2024
Instituto de Salud Carlos III
2016-2024
University of Geneva
2009-2024
Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition
2024
Institut de Biomedicina de la Universitat de Barcelona
2018-2023
Centro de Investigación Biomédica en Red
2016-2023
Hospital Sant Joan de Déu Barcelona
2016-2022
Hospital de Sant Pau
2020
Institut de Recerca Sant Joan de Déu
2017
The thermogenic activity of brown adipose tissue (BAT) and browning white are important components energy expenditure. Here we show that GPR120, a receptor for polyunsaturated fatty acids, promotes fat activation. Using RNA-seq to analyse mouse BAT transcriptome, find the gene encoding GPR120 is induced by We further activation induces in mice, whereas GRP120-null mice impaired cold-induced browning. Omega-3 acids induce beige adipocyte differentiation activation, these effects require...
BACKGROUND AND PURPOSE mTOR inhibitors are currently used as immunosuppressants in transplanted patients and promising anti‐cancer agents. However, new‐onset diabetes is a frequent complication occurring treated with such rapamycin (Sirolimus). Here, we investigated the mechanisms associated diabetogenic effects of chronic Sirolimus administration rats vitro cell cultures. EXPERIMENTAL APPROACH was administered to fed either standard or high‐fat diet for 21 days. Metabolic parameters were...
Multipotent mesenchymal stromal cells (MSC) are currently investigated clinically as cellular therapy for a variety of diseases. Differentiation MSC toward endodermal lineages, including hepatocytes and their therapeutic effect on fibrosis has been described but remains controversial. Recent evidence attributed fibrotic potential to MSC. As differentiation might be dependent donor age, we studied derived from adult pediatric human bone marrow differentiate into or myofibroblasts in vitro...
Hepatocellular carcinoma (HCC) is a deadly malignancy characterized at the epigenetic level by global DNA hypomethylation and focal hypermethylation on promoter of tumor suppressor genes. In most cases it develops background liver steatohepatitis, fibrosis, cirrhosis. Guadecitabine (SGI-110) second-generation hypomethylating agent, which inhibits methyltransferases. formulated as dinucleotide decitabine deoxyguanosine that resistant to cytidine deaminase (CDA) degradation results in...
Abstract: Hepatitis C virus (HCV) perturbs the host's lipid metabolism and often results in hepatic steatosis. In nonalcoholic fatty liver disease, intrahepatic down-regulation of phosphatase tensin homolog deleted on chromosome 10 (PTEN) is a critical mechanism leading to steatosis its progression toward fibrosis hepatocellular carcinoma. However, whether an HCV infection triggers formation large droplets through PTEN-dependent mechanisms unknown. We assessed PTEN expression livers patients...
Background Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide. Prevention and risk reduction are important identification specific biomarkers for early diagnosis HCC represents an active field research. Increasing evidence indicates that fat accumulation in liver, defined as hepatosteatosis, independent strong factor developing HCC. MacroH2A1, a histone protein generally associated with repressed regions chromosomes, involved hepatic lipid metabolism present two...
Peroxisome-proliferator-activated receptors (PPARs) are ligand-activated nuclear that exert in the liver a transcriptional activity regulating whole spectrum of physiological functions, including cholesterol and bile acid homeostasis, lipid/glucose metabolism, inflammatory responses, regenerative mechanisms, cell differentiation/proliferation. Dysregulations expression, or activity, specific PPAR isoforms therefore believed to represent critical mechanisms contributing development hepatic...
Abstract Obesity and type 2 diabetes are becoming a global sociobiomedical burden. Beige adipocytes emerging as key inducible actors putative relevant therapeutic targets for improving metabolic health. However, in vitro models of human beige adipose tissue currently lacking hinder research into this cell biotherapy development. Unlike traditional bottom‐up engineering approaches that aim to generate building blocks, here scalable system is proposed pre‐vascularized functional organoids...
Abstract Brown adipose tissue (BAT) is known to secrete regulatory factors in response thermogenic stimuli. Components of the BAT secretome may exert local effects that contribute recruitment and activation. Here, we found a stimulus leads enhanced secretion kininogen (Kng) by BAT, owing induction 2 ( Kng2 ) gene expression. Noradrenergic, cAMP-mediated signals induce KNG2 expression release brown adipocytes. Conversely, kinin receptors, are activated Kng products bradykinin...
GDF11 is a member of the TGF-β superfamily that was recently implicated as potential "rejuvenating" factor, which can ameliorate metabolic disorders. The main objective presented study to closely characterize role signaling in glucose homeostasis and differentiation white adipose tissue.We performed microscopy imaging, biochemical transcriptomic analyses tissues 9 weeks old ob/ob mice murine human pre-adipocyte cell lines.Our vivo experiments employing treatment showed improved...
Objective Since oncostatin m (OSM) is elevated in adipose tissue conditions of obesity and type 2 diabetes mice humans, the aim this study was to determine whether cytokine plays a crucial role impairment brown (BAT) activity browning capacity that has been observed people with obesity. Methods C57BL/6J rendered obese by high‐fat diet, their lean controls, fed standard diet implanted subcutaneously mini pump through surgical procedure deliver OSM or placebo were used. Preadipocytes fully...
Background & aims: Growth Differentiation Factor 11 (GDF11) is an anti-aging factor, yet its role in liver diseases not established.We evaluated the of GDF11 healthy conditions and transition from non-alcoholic fatty disease (NAFLD) to steatohepatitis (NASH).Results: mRNA levels positively correlated with NAFLD activity score CPT1, SREBP, PPARγ Col1A1 levels, associated portal fibrosis, morbidly obese patients NAFLD/NASH.GDF11treated mice showed mildly exacerbated hepatic collagen...
Depending on its anatomical placement, perivascular adipose tissue (PVAT) has been found to possess features more (e.g., aortic thoracic) or less abdominal) similar brown/beige in mice, whereas PVAT surrounding the mesenteric arteries and caudal part of abdominal aorta is white fat. thought influence vascular function through effects adipose-secreted molecules vessels. Brown was recently shown play differential secretory role via secretion so-called batokines but involvement batokine...
Background: Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide.Prevention and risk reduction are important identification specific biomarkers for early diagnosis HCC represents an active field research.Increasing evidence indicates that fat accumulation in liver, defined as hepatosteatosis, independent strong factor developing HCC.MacroH2A1, a histone protein generally associated with repressed regions chromosomes, involved hepatic lipid metabolism present two...
AIM:To investigate the protein expression of phosphatase and tensin homolog (PTEN) in human liver biopsies patients with alcoholic non-alcoholic disease.