A5080533897- GDF15 and Related Biomarkers
- Adipose Tissue and Metabolism
- Nutrition and Health in Aging
- Fibroblast Growth Factor Research
- Connective Tissue Growth Factor Research
- Lipid metabolism and biosynthesis
- Parathyroid Disorders and Treatments
- Adipokines, Inflammation, and Metabolic Diseases
- Macrophage Migration Inhibitory Factor
- Pancreatic function and diabetes
- Pancreatitis Pathology and Treatment
- Muscle Physiology and Disorders
- Kruppel-like factors research
- S100 Proteins and Annexins
- Cytokine Signaling Pathways and Interactions
- Advanced Numerical Analysis Techniques
- Mitochondrial Function and Pathology
- Ion Transport and Channel Regulation
- Retinoids in leukemia and cellular processes
- Vitamin D Research Studies
- Neurobiology and Insect Physiology Research
- HIV-related health complications and treatments
- Metabolism, Diabetes, and Cancer
- Neonatal Respiratory Health Research
- Fatty Acid Research and Health
Universitat de Barcelona
2016-2023
Sant Joan de Déu Research Foundation
2019-2023
Centro de Investigación Biomédica en Red
2016-2022
Institut de Biomedicina de la Universitat de Barcelona
2016-2019
Institute for Research in Biomedicine
2019
Instituto de Salud Carlos III
2019
Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition
2016-2019
Background We previously described increased levels of growth and differentiation factor 15 (GDF-15) in skeletal muscle serum patients with mitochondrial diseases. Here we evaluated GDF-15 as a biomarker for diseases affecting children compared it to fibroblast-growth 21 (FGF-21). To investigate the mechanism induction these pathologies measured its expression secretion response dysfunction. Methods analysed 59 samples from 48 disease, 19 other neuromuscular 33 aged-matched healthy children....
Transcriptomic analysis of gene expression in brown adipose tissue (BAT) from mice response to cold revealed strong induction growth and differentiation factor 15 (GDF15). This study aimed characterize GDF15 as a adipokine released thermogenic activation determine its target functions.GDF15 was measured tissues physiological pharmacological modulators thermogenesis. Brown beige cell cultures were used dissect the mechanisms regulating expression. adipocyte cellular models fibroblast 21...
Abstract Brown adipose tissue (BAT) is known to secrete regulatory factors in response thermogenic stimuli. Components of the BAT secretome may exert local effects that contribute recruitment and activation. Here, we found a stimulus leads enhanced secretion kininogen (Kng) by BAT, owing induction 2 ( Kng2 ) gene expression. Noradrenergic, cAMP-mediated signals induce KNG2 expression release brown adipocytes. Conversely, kinin receptors, are activated Kng products bradykinin...
Background. Recreational marathon runners face strong physiological challenges. Assessment of potential biomarkers for the biological responses will help to discriminate individual race responsiveness and their consequences. This study sought analyze changes in plasma levels GDF15 FGF21, novel endocrine factors related metabolic stress, following strenuous exercise a race. Methods. Blood samples were obtained from eighteen male (mean + SD, age: 41.7 5.0 years, BMI: 23.6 1.8) 48h before,...
Fibroblast growth factor-21 (FGF21) is a hormonal regulator of metabolism; it promotes glucose oxidation and the thermogenic capacity adipose tissues. The levels β-klotho (KLB), co-receptor required for FGF21 action, are decreased in brown (BAT) white (WAT) tissues during obesity, diabetes, lipodystrophy. Reduced have been proposed to account resistance these conditions. In this study, we explored whether downregulation affects metabolic regulation responsiveness using mice with total...
Oncostatin M (OSM) plays a key role in inflammation, but its regulation and function during obesity is not fully understood.The aim of this study was to evaluate the relationship OSM with inflammatory state that leads impaired glucose homeostasis obesity. We also assessed whether immunoneutralization could revert metabolic disturbances caused by high-fat diet (HFD) mice.28 patients severe were included stratified into two groups: (1) levels <100 mg/dL (2) >100 mg/dL. White adipose tissue...
Adaptive induction of thermogenesis in brown adipose tissue (BAT) is essential for the survival mammals after birth. We show here that G protein-coupled receptor protein 120 (GPR120) expression dramatically induced birth mouse BAT. GPR120 neonatal BAT highest among GPR120-expressing tissues at any developmental stage tested. The caused by postnatal thermal stress rather than initiation suckling. GPR120-null neonates were found to be relatively intolerant cold: close one-third did not survive...
Objective: People living with HIV (PLWH) have an increased cardiovascular risk (CVR) owing to dyslipidemia, insulin resistance, metabolic syndrome, and HIV/combination antiretroviral therapy (cART)-associated lipodystrophy (HALS). Atherosclerosis inflammation are related growth differentiation factor-15 (GDF15). The relationship between disturbances, HALS, CVR GDF15 in PLWH is not known. Research design methods: Circulating levels 152 (with HALS = 60, without 43, cART-naïve 49) 34 healthy...
S100A4 has been recently identified as an adipokine associated with insulin resistance (IR) in adult subjects obesity. However, no data about its levels children obesity and only a few approaches regarding potential mechanism of action have reported. To obtain deeper understanding the role obesity, (a) were measured prepubertal without studied relationship IR (b) effects cultured human adipocytes vascular smooth muscle cells (VSMCs) determined.