A5003288226- Renal Transplantation Outcomes and Treatments
- Cardiovascular Function and Risk Factors
- Cardiac Valve Diseases and Treatments
- Dialysis and Renal Disease Management
- Healthcare Systems and Reforms
- Organ Donation and Transplantation
- Organ Transplantation Techniques and Outcomes
- Cardiac Fibrosis and Remodeling
- Chronic Kidney Disease and Diabetes
- Nitric Oxide and Endothelin Effects
- Cytomegalovirus and herpesvirus research
- Renal Diseases and Glomerulopathies
- Cancer Genomics and Diagnostics
- Healthcare Policy and Management
- Colorectal Cancer Surgical Treatments
- Mitochondrial Function and Pathology
- Colorectal and Anal Carcinomas
- Cardiac Ischemia and Reperfusion
- Anorectal Disease Treatments and Outcomes
- Transplantation: Methods and Outcomes
- Organ and Tissue Transplantation Research
- Eicosanoids and Hypertension Pharmacology
- Energy Harvesting in Wireless Networks
- Polyomavirus and related diseases
- S100 Proteins and Annexins
West China Hospital of Sichuan University
2006-2025
Sichuan University
2004-2025
Dalian University of Technology
2025
Haikou City People's Hospital
2025
General Hospital of Shenyang Military Region
2023
Zhejiang University
2018-2022
State Administration of Traditional Chinese Medicine of the People's Republic of China
2020-2022
Zhejiang Center for Disease Control and Prevention
2019-2022
National Clinical Research Center for Digestive Diseases
2020-2022
Shanghai Clinical Research Center
2022
Abstract Aortic valve calcification is a lethal valvular heart disease lacking effective drug therapy. However, whether uric acid involved in the development of aortic unclear. Two‐sample Mendelian randomization (MR) analyses confirmed causal relationship between and disease. Uric levels were assessed tissue from patients with/without calcification. To investigate impact hyperuricemia on calcification, apolipoprotein E knockout (ApoE −/− ) mice fed high‐fat diet (HFD) also given an adenine...
Background. After myocardial infarction, anti-inflammatory macrophages perform key homeostatic functions that facilitate cardiac recovery and remodeling. Several studies have shown lactate may serve as a modifier influences phenotype of macrophage. However, the therapeutic role sodium in infarction (MI) is unclear. Methods. MI was established by permanent ligation left anterior descending coronary artery followed injection saline or lactate. Cardiac function assessed echocardiography. The...
This study was aimed to investigate the associations of serum calcium, phosphate, and vitamin D levels with risk developing aortic stenosis (AS).We included 296 415 participants who were free prior diagnosis any valvular heart disease from UK Biobank. Serum measured. Incidental AS determined by records hospital data. Cox regression used examine association mineral incidental after adjustment for potential confounders. The mean age 56.4 years (SD 8.14) 53.3% women. During an average follow-up...
Abstract Stromal cell‐derived factor‐1 (SDF‐1) is a well‐characterized cytokine that protects heart from ischaemic injury. However, the beneficial effects of native SDF‐1, in terms promoting myocardial repair, are limited by its low concentration myocardium. Annexin V (AnxA5) can precisely detect dead cells vivo. As massive cardiomyocytes die after MI, we hypothesize AnxA5 be used as an anchor to carry SDF‐1 In this study, constructed fusion protein consisting and domains. The receptor...
Abstract Donor‐derived cell‐free DNA (dd‐cfDNA) is a promising biomarker for monitoring allograft status. However, whether dd‐cfDNA can reflect real‐time anti‐rejection treatment effects remains unclear. We prospectively recruited 28 patients with acute renal rejection, including 5 ABMR, 12 type IA or IB and 11 IIA IIB rejection. levels in peripheral blood were measured using human single nucleotide polymorphism (SNP) locus capture hybridization. The percentage of (dd‐cfDNA%) declined...
Abstract Background There are conflicting research results about the survival differences between hemodialysis(HD) and peritoneal dialysis (PD). The present study estimated relative mortality hazard for incident HD PD patients with end stage renal disease (ESRD) in eastern China. Methods This examined a cohort of ESRD who initiated therapy Zhejiang province Jan 2010 Dec 2014, followed up until 2015. were matched 1:1 fashion patients, Kaplan–Meier analysis was used to explore them. Cox...
The clinical efficiency and adverse reactions of anlotinib in metastatic colorectal cancer (mCRC) as a third-line treatment compared with chemotherapy regorafenib or fruquintinib was explored this study. Clinical data from 105 mCRC patients who failed at least two lines were collected. divided into three groups based on their therapeutic regimen: only (group A); B); C). result showed that the ORR DCR group B (14.29%, 85.71%) higher than those A (0%, 40.00%). ORRs C 14.29% 20.00%,...
Abstract ABO‐incompatible living kidney transplantation is nowadays a routine procedure to expand donor pool. The past decades have seen the evolution of desensitization protocol and immunosuppression regimen. Despite increased bleeding events, infectious complications, rejection episodes reported in some studies, favorable graft patient survival rate are now achieved, regardless various protocols among transplant centers. Several issues such as usage rituximab standardization blood group...
This study aimed to analyze changes the drug spectrum and clinicopathological features of drug-induced acute kidney injury (AKI) with recent medication habits changes.A retrospective analysis characteristics patients diagnosed AKI from January 2012 October 2016 period at First Affiliated Hospital Medical College Zhejiang University was conducted.Between 2016, 909 were AKI. Of these, 228 drug-related engaged in this study, including 51 who underwent renal biopsies, 74 treated antibacterial...
MARCH5 is a critical regulator of mitochondrial dynamics, apoptosis and mitophagy. However, its role in cardiovascular system remains poorly understood. This study aimed to investigate the endothelial cell (ECs) injury involvement Akt/eNOS signalling pathway this process. Rat models myocardial infarction (MI) human cardiac microvascular cells (HCMECs) exposed hypoxia (1% O2 ) were used study. expression was significantly reduced ECs MI hearts hypoxia. Hypoxia inhibited proliferation,...
Lipid overload is intimately connected with the change of endothelial epigenetic status which impacts cellular signaling activities and function. Activating transcription factor 4 (ATF4) involved in regulation lipid metabolism meanwhile an modifier. However, role ATF4 angiogenesis under not well understood. Here, to induce status, we employed high-fat diet (HFD)-induced obese mouse model vivo palmitic acid (PA) stimulate cells vitro. Compared mice fed normal chow (NCD), HFD-induced showed...
Objectives: In China, there are two major medical insurance models: the Urban Basic Medical Insurance (UBMI) and New Cooperative Scheme (NCMS). The aim of present study was to evaluate association type patients undergoing hemodialysis (HD) with their survival.Methods: We retrospectively analyzed end-stage renal disease adult initiating HD between January 2010 December 2014 in Zhejiang province, followed up through 31 2015. Patients who had received for over 3 months were separated into...
Objectives . We aimed to assess the procedural and clinical results of transcatheter aortic valve replacement (TAVR) for nonraphe bicuspid stenosis (AS) with coronary vs mixed cusp fusion. Background It remains unclear whether fusion morphology affects TAVR outcomes in patients AS. Methods This retrospective study enrolled consecutive severe symptomatic AS type-0 valve, who underwent at our institution between 2012 2017. were defined based on Valve Academic Research Consortium-2...
Background: Chronic refractory dialysis hypotension (CRDH) is a serious issue in patients waiting for transplants. It leads to fatal clinical outcomes and disqualification from kidney transplantation. Kidney transplantation pediatric donor adult patient with lower blood pressure (BP) may be an option. No related study has been reported we conducted this first evaluate the effect of CRDH recipients. Methods: Ten single-kidney transplantations small donors after cardiac death our center...
Objective: To investigate the surgical efficacy of neurosurgery robot deep brain stimulation(DBS) in treatment elderly Parkinson's disease(PD). Methods: The clinical data patients (≥75 years) with PD who underwent neurosurgical robot-assisted DBS surgery Department Neurosurgery General Hospital Northern Theater Command from September 2016 to 2022 were collected retrospectively. Operation time, electrode implantation duration, postoperative pneumocephalus volume, accuracy, Tao's scale,...
Recent studies have confirmed the role of plasma donor-derived cell-free DNA (ddcfDNA) as a reliable non-invasive biomarker for allograft injury after kidney transplantation. Whereas variability ddcfDNA levels among recipients has limited their clinical use. This study aimed to explore intrinsic factors associated with elevation by investigating impact Banff lesions and inflammatory infiltrates on in transplant recipients. From March 2017 September 2019, total 106 matched biopsies were...