A5023542504- Neuroscience and Neuropharmacology Research
- Adipose Tissue and Metabolism
- Receptor Mechanisms and Signaling
- Lipid Membrane Structure and Behavior
- Photoreceptor and optogenetics research
- Sirtuins and Resveratrol in Medicine
- Adipokines, Inflammation, and Metabolic Diseases
- Lipid metabolism and biosynthesis
University Hospital Bonn
2024
University of Bonn
2024
University of Würzburg
2020-2023
University of Khartoum
2020
Abstract Brown adipose tissue (BAT) is a central thermogenic organ that enhances energy expenditure and cardiometabolic health. However, regulators specifically increase the number of adipocytes are still an unmet need. Here, we show cAMP-binding protein EPAC1 regulator adaptive BAT growth. In vivo, selective pharmacological activation increases mass browning white fat, leading to higher reduced diet-induced obesity. Mechanistically, coordinates network for proliferation in adipocytes, but...
Super-resolution imaging reveals close association between mGluR4, Ca V 2.1, and Munc-18-1 at cerebellar active zones.
Abstract The γ-aminobutyric acid type B (GABA ) receptor is a prototypical family C G protein-coupled (GPCR) that plays key role in the regulation of synaptic transmission. Although growing evidence suggests GPCR signaling neurons might be highly organized time and space, limited information available about mechanisms controlling nanoscale organization GABA receptors other GPCRs on neuronal plasma membrane. Using combination biochemical assays vitro, single-particle tracking,...