A5046080040- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- Angiogenesis and VEGF in Cancer
- RNA Interference and Gene Delivery
- Cancer-related Molecular Pathways
- Nanoplatforms for cancer theranostics
- Lung Cancer Treatments and Mutations
- Cancer, Hypoxia, and Metabolism
- Cancer-related gene regulation
- Cancer Mechanisms and Therapy
- Virus-based gene therapy research
- Epigenetics and DNA Methylation
- FOXO transcription factor regulation
- RNA modifications and cancer
- Photodynamic Therapy Research Studies
- Hepatocellular Carcinoma Treatment and Prognosis
- Metabolism, Diabetes, and Cancer
- Genomics, phytochemicals, and oxidative stress
- Drug Transport and Resistance Mechanisms
- MRI in cancer diagnosis
- Telomeres, Telomerase, and Senescence
- NF-κB Signaling Pathways
- Occupational and environmental lung diseases
- Chemokine receptors and signaling
Dalian Medical University
2025
First Affiliated Hospital of Dalian Medical University
2025
Hebei Medical University
2024
Fourth Hospital of Hebei Medical University
2024
Guangdong Medical College
2012-2023
Kunming University of Science and Technology
2023
First People's Hospital of Yunnan Province
2023
Sun Yat-sen University
2010-2013
Sun Yat-sen University Cancer Center
2010-2013
State Key Laboratory of Oncology in South China
2011
Overexpressed DNA methyltransferase 1 (DNMT1) strongly contributes to tumor suppressor gene silencing in colorectal cancer (CRC). However, the underlying mechanism of DNMT1 overexpression is still unclear. MicroRNAs (miRNA) have been implicated as regulators controlling diverse biological processes, including carcinogenesis. In this study, we investigated whether some miRNA involved regulation and thus play a functional role CRC. Our results showed that miR-342 was downregulated CRC tissues...
The aim of this study was to investigate the effect microRNA-20a on pancreatic carcinoma cell proliferation and invasion find a new effective treatment strategy for carcinoma. MicroRNA-20a expression determined in 10 matched normal tissues by situ hybridization. Quantitative real-time RT-PCR used evaluate two lines (BxPC-3 Panc-1) immortal human duct epithelial line H6C7. Proliferation capacity were analyzed cells with lentivirus-mediated overexpression both vitro vivo. In addition,...
Background Hypoxic tumor cells can reduce the efficacy of radiation. Antiangiogenic therapy may transiently "normalize" vasculature to make it more efficient for oxygen delivery. The aim this study is investigate whether recombinant human endostatin (endostar) create a "vascular normalization window" alleviate hypoxia and enhance inhibitory effects radiation in nasopharyngeal carcinoma (NPC) mice. Methodology/Principal Findings Transient changes morphology hypoxic cell fraction response...
Background: There is mounting evidence that microRNAs play an important role in nasopharyngeal carcinoma, which widely prevalent South China and the most metastatic cancer among head neck cancers. Recently, it has been shown miR-494 involved progression prognosis of carcinoma. However, little known about function mechanism miR-494-3p In present study, we aimed to investigate effects on migration invasion carcinoma further explore underlying mechanisms these processes. Methods: The expression...
Nasopharyngeal carcinoma (NPC), which has the highest incidence in South China, is mainly treated by radiotherapy. However, survival rate remains low. Angiogenesis closely correlated with progress of NPC. Thus, combination anti‐angiogenesis radiation an attractive strategy for NPC treatment. A heterogenic xenografted human nude mice model was established to investigate effect pigment epithelium‐derived factor (PEDF), a potent anti‐angiogenic factor, and combined PEDF radiotherapy on...
Lung cancer is a leading cause of cancer-associated mortality worldwide. The cisplatin (DDP)‑based chemotherapy remains the foundation treatment for majority patients affected by advanced non‑small cell lung (NSCLC). However, DDP‑resistance limits clinical utility this drug in with NSCLC. aim present study was to investigate inhibitory effect niclosamide on human growth and possible underlying mechanism. effects proliferation adenocarcinoma (A549) DDP‑resistant (CR) (A549/DDP) cells were...
Background: Autophagy plays an important role in the development of cancer. However, prognostic value autophagy-related genes (ARGs) cervical cancer (CC) is unclear. The purpose this study to construct a survival model for predicting prognosis CC patients based on ARG signature. Methods: ARGs were obtained from Human Database and Molecular Signatures Database. expression profiles clinical data downloaded TCGA database. Differential analysis tissues normal was performed using R software...
Abstract: Non-small cell lung cancer (NSCLC) is the major cause of deaths among all types worldwide. Most NSCLC diagnosed at an advanced stage and 5-year overall survival rate low. The reason for low patients with mainly due to distant metastasis. Matrine, a traditional Chinese medicine, has been shown significant anti-proliferation anti-invasive effect in tumors. However, little known on mechanism matrine cancer. Therefore, we tried investigate molecular invasive ability cells vitro. Cell...
Background Nonviral vectors are attractively used for gene therapy owing to their distinctive advantages. Our previous study has demonstrated that transfer of human IFNγ into nasopharyngeal carcinoma (NPC) by using a novel nonviral vector, minicircle (mc), under the control cytomegalovirus (CMV) promoter was effective inhibit tumor growth. However, therapies based on CMV cannot express targeted genes in cancer tissues. Previous studies indicated development NPC closely associated with...
Nasopharyngeal carcinoma (NPC) is associated with a high incidence rate in South China and predominantly treated radiotherapy; however, the survival remains low. The therapeutic effects of radiation chemotherapy may be enhanced when combined anti‑sense oligonucleotides targeting human telomerase RNA (hTR ASODN). However, influence hTR ASODN on anti‑tumor NPC remain unknown. present study investigated proliferation radiosensitivity cells, further explored underlying mechanisms. significantly...
Lung cancer is one of the leading causes cancer‑associated mortality, worldwide. The overall survival rate remains low, but progress has been made in improving diagnosis and treatment lung over past decades. Niclosamide, a salicylanilide derivative used for tapeworm infections, safe, well tolerated, inexpensive readily available. Previous studies have identified niclosamide as potential anticancer agent. present study demonstrated that enhanced effect irradiation by inhibiting...
The aim of the present study was to investigate whether niclosamide could sensitize nasopharyngeal carcinoma cells radiation and further explore underlying mechanisms. CCK-8 assay used determine effect on proliferation NPC cells. Colony formation evaluate radiosensitizing Flow cytometry analysis apoptosis induced by niclosamide. Immunofluorescent staining detect γ-H2AX foci localization Ku70/80 proteins in Real-time PCR quantification examine level mRNA. DNA damage repair-related were...
Abstract Oxidative stress refers to the process of reactive oxide species (ROS) increase in human body due various factors, which leads oxidative damage tissues. Current studies have confirmed that sustained is one distinctive features throughout development tumors. Numerous reports shown lncRNAs can regulate through multiple pathways. However, relationship between glioma-associated and not clearly investigated. RNA sequencing data GBM (glioblastoma) LGG (low grade glioma) corresponding...
EHMT2 (euchromatic histone lysine methyltransferase 2), a methyltransferase, has been shown to be involved in multiple human cancers. In this study, we determined mRNA and protein expression of cervical cancer cells normal epithelial cells. was inhibited with short hairpin RNA (shEHMT2) Cell viability, colony proliferation, apoptosis, adhesion, invasion assays Western blot were performed assess the function EHMT2. As result, upregulated compared Suppression impairs cell proliferation induces...
The aim of this study was to establish an ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) method for the detection osimertinib in rat plasma, lung and brain tissues. Forty-eight rats were randomly divided into experimental group (receiving at doses 5, 8, 10 mg/kg) a control group. After continuous intragastric administration 15 days, samples blood, lung, tissue collected. Chromatographic separation achieved using BEH C18 column with gradient elution, employing...