A5100320102- Extracellular vesicles in disease
- Mesenchymal stem cell research
- Tissue Engineering and Regenerative Medicine
- MicroRNA in disease regulation
- Renal and related cancers
- Single-cell and spatial transcriptomics
- Lanthanide and Transition Metal Complexes
- Electrospun Nanofibers in Biomedical Applications
- RNA Interference and Gene Delivery
- Neonatal Respiratory Health Research
- Magnetism in coordination complexes
- Electrochemical Analysis and Applications
- Cancer-related gene regulation
- Perovskite Materials and Applications
- Inflammasome and immune disorders
- Skin Protection and Aging
- Analytical chemistry methods development
- Telomeres, Telomerase, and Senescence
- Circular RNAs in diseases
- Graphene and Nanomaterials Applications
- Nanoplatforms for cancer theranostics
- Acute Kidney Injury Research
- Pulmonary Hypertension Research and Treatments
- Image and Object Detection Techniques
- Supramolecular Self-Assembly in Materials
Sichuan University
2025
Nagoya University Hospital
2022-2025
Ningxia Medical University
2024
Nankai University
2009-2024
Harbin Medical University
2024
First Affiliated Hospital of Harbin Medical University
2024
Changhai Hospital
2024
Second Military Medical University
2024
Naval University of Engineering
2024
Nanchang University
2023
Background: Mesenchymal stem cell (MSC)-based therapies hold great promise for the treatment of inflammatory bowel disease (IBD). In order to optimize and maximize therapeutic benefits MSCs, we investigated whether cotransplantation a chitosan (CS)-based injectable hydrogel with immobilized IGF-1 C domain peptide (CS-IGF-1C) human placenta-derived MSCs (hP-MSCs) could ameliorate colitis in mice. Methods: IGF-1C was generated by immobilizing CS hydrogel. Colitis induced 2,4,6-trinitrobenzene...
Mesenchymal stem cell (MSC)-derived extracellular vesicles (EVs) have been shown to therapeutic potential for ischemic diseases and are considered an alternative therapy. However, the low retention poor stability of EVs post-transplantation in vivo remain obstacle prior clinical application EVs.This study was designed investigate whether collagen matrix could increase further improve effects murine acute kidney injury (AKI) model. were isolated from human placental MSCs (hP-MSC-EVs)...
Abstract Background The senescence of dermal fibroblasts (DFLs) leads to an imbalance in the synthesis and degradation extracellular matrix (ECM) proteins, presenting so-called senescence-associated secretory phenotype (SASP), which ultimately skin aging. Recently, mesenchymal stem cell (MSC)-derived vesicles (EVs) have been recognized as a promising cell-free therapy for degenerative diseases, opens new avenue aging treatment. Methods In this study, we utilized chitosan (CS) hydrogel...
Abstract Endothelial cell injury plays a critical part in ischemic acute kidney (AKI) and participates the progression of AKI. Targeting renal endothelial therapy may ameliorate vascular further improve prognosis Here, P‐selectin as biomarker AKI cells is identified binding peptide (PBP)‐engineered extracellular vesicles (PBP‐EVs) with imaging therapeutic functions are developed. The results show that PBP‐EVs exhibit selective targeting tendency to injured kidneys, while providing...
Abstract L ‐cysteine functionalized multi‐walled carbon nanotubes (MWCNTs‐cysteine) are synthesized and characterized by XPS, FT‐IR, XRD, TEM. The capability of MWCNTs‐cysteine for selective separation preconcentration heavy metal ions statically dynamically evaluated with Cd 2+ as a model ion. Unlike MWCNTs, the sorption onto is not influenced ionic strength in wide range. demonstrated to be good column packings on‐line microcolumn . Effective on packed achieved pH range 5.5 8.0. retained...
Two novel two-dimensional 3d–4f networks based on planar Co4Ln2 clusters supported by rigid 4′-(4-carboxyphenyl)-2,2′:6′,2″-terpyridine afford the first examples of high-dimensional with behaving as single-molecule magnets.
Abstract Background Mesenchymal stem cells (MSCs) have demonstrated remarkable therapeutic promise for acute lung injury (ALI) and its severe form, respiratory distress syndrome (ARDS). MSC secretomes contain various immunoregulatory mediators that modulate both innate adaptive immune responses. Priming MSCs has been widely considered to boost their efficacy a variety of diseases. Prostaglandin E2 (PGE2) plays vital role in physiological processes mediate the regeneration injured organs....
Aging is a degenerative process that leads to tissue dysfunction and death. Embryonic stem cells (ESCs) have great therapeutic potential for age-related diseases due their capacity self-renewal plasticity. However, the use of ESCs in clinical treatment limited by immune rejection, tumourigenicity ethical issues. ESC-derived extracellular vesicles (EVs) may provide effects are comparable those while avoiding unwanted effects. Here, we fully evaluate role ESC-EVs rejuvenation vitro vivo. Using...
Abstract Background Intravenous administration of mesenchymal stromal cells (MSCs) has an acknowledged competence cardiac repair, despite a lack systematic description the underlying biological mechanisms. The lung, but not heart, is main trapped site for intravenously transplanted MSCs, which leaves spatial gap between MSCs and injured myocardium. How lung-trapped after intravenous transplantation rejuvenate myocardium remains unknown. Methods were isolated from human placenta tissue,...
Abstract Background Rho-kinase is a serine/threonine kinase and regulates actin dynamics. There are two subtypes: 1 2. Recently, we found that Rho-kinase1/2 inhibitor, fasudil, ameliorated schizophrenia-like behaviors in MK-801-treated mice (Takase et al., 2022). However, fasudil has been shown side effects, such as hypotension, which may hinder its clinical application for schizophrenia. Since 2 predominantly expressed brain, hypothesized selective inhibition of might exhibit...
Self‐sustained actuators powered by natural, low‐energy sources based on liquid crystal elastomers (LCEs) are attractive as they offer high safety, abundant energy availability, and practicality in applications. However, achieving stable self‐sustaining motion with requires actuation strain rates within a narrow temperature range near ambient conditions—a great challenge LCEs low nematic‐to‐isotropic transition temperatures (Tni) generally exhibit reduced rates. To address this, we...
By providing a stem cell microenvironment with particular bioactive constituents in vivo, synthetic biomaterials have been progressively successful cell-based tissue regeneration by enhancing the engraftment and survival of transplanted cells. Designs motifs to influence behavior D-form amino acids modulate scaffold stability may be critical for development optimization self-assembling biomimetic hydrogel scaffolds therapy.In this study, we linked naphthalene (Nap) covalently short peptide...
Abstract Background Embryonic stem cell-derived extracellular vesicles (ESC-EVs) possess therapeutic potential for a variety of diseases and are considered as an alternative ES cells. Acute kidney injury (AKI) is common acute severe disease in clinical practice, which seriously threatens human life health. However, the roles mechanisms ESC-EVs on AKI remain unclear. Methods In this study, we evaluated effects physiological repair pathological using murine ischemia-reperfusion injury-induced...
Prostaglandin E2 (PGE2) has recently been recognized to play a role in immune regulation and tissue regeneration. However, the short half-life of PGE2 limits its clinical application. Improving delivery specifically target organ with prolonged release method is highly desirable. Taking advantage adequate space proximity renal parenchyma, subcapsular allows minimally invasive effective entire kidney. Here, we report that by covalently cross-linking it collagen matrix, exhibits an long-term...
Nitric oxide (NO), as a gaseous therapeutic agent, shows great potential for the treatment of many kinds diseases. Although various NO delivery systems have emerged, immunogenicity and long-term toxicity artificial carriers hinder clinical translation these gas therapeutics. Mesenchymal stem cells (MSCs), with capacities self-renewal, differentiation, low immunogenicity, been used living carriers. However, MSCs signaling molecule (GSM) not reported. In this study, human were genetically...
Uncovering mechanisms of endogenous regeneration and repair through resident stem cell activation will allow us to develop specific therapies for injuries diseases by targeting lineages. Sox9
Abstract Necroptosis and ferroptosis are two distinct forms of necrotic-like cell death in terms their morphological features regulatory mechanisms. These types can coexist disease contribute to pathological processes. Inhibition both necroptosis has been shown enhance therapeutic effects treating complex necrosis-related diseases. However, targeting by a single compound be challenging, as these involve molecular pathways. In this study, we discovered that KW-2449, previously described...
Liver fibrosis poses a significant global health burden, in which hepatic stellate cells (HSCs) play crucial role. Targeted nanomedicine delivery systems directed at HSCs have shown immense potential the treatment of liver fibrosis. Herein, bioinspired material, engineered therapeutic miR-181a-5p (a miRNA known to inhibit fibrotic signaling pathways) and targeted moiety hyaluronic acid (HA) co-functionalized extracellular vesicles (EVs) are developed. HA is incorporated onto surface EVs...
Three series of NiII-LnIII complexes were synthesized with the general formulae [(μ3-CO3)2{Ni(HL)(CH3-CH2OH)Ln(CH3COO)}2]·2CH3CH2OH (1-6) (Ln = Tb (1), Dy (2), Ho (3), Er (4), Tm (5), Yb (6); H3L N,N'-bis(3-methoxysalicylidene)-1,3-diamino-2-prop-anol), [Ni(HL)Ln(dbm)3]·CH3OH2·2CH2Cl2 (7-10) (7), Eu (8), Gd (9), (10); Hdbm 1,3-diphenyl-1,3-propanedione) and [Ni(HL)(H2O)(tfa)Ln(hfac)2] (11-15) (11), (12), (13), (14), (15); Hhfac 1,1,1,5,5,5-hexafluoropentane-2,4-dione, tfa- trifluoroacetate)...
Background: In recent years, a mass of studies have shown that pyroptosis plays an important role in the proliferation vascular smooth muscle cells (VSMCs). We investigated whether angiotensin II (Ang II) induces rat aortic VSMCs and NOD-like receptor family pyrin domain containing 3 (NLRP3) this process. Additionally, we explored effect related mechanism recombinant tissue factor pathway inhibitor (rTFPI) Ang II-induced VSMC pyroptosis. Methods: Cultured were divided into five groups:...