A5065136372- Receptor Mechanisms and Signaling
- Neurotransmitter Receptor Influence on Behavior
- Neuroscience and Neuropharmacology Research
- Phosphodiesterase function and regulation
- Bipolar Disorder and Treatment
- Traditional Chinese Medicine Analysis
- Traditional Chinese Medicine Studies
- Neurogenesis and neuroplasticity mechanisms
- Health, Environment, Cognitive Aging
- Adipose Tissue and Metabolism
- Memory and Neural Mechanisms
- Genetics and Neurodevelopmental Disorders
- Pain Mechanisms and Treatments
- Plant and animal studies
- Neurobiology and Insect Physiology Research
- Creativity in Education and Neuroscience
- Cognitive Science and Mapping
- Congenital heart defects research
- Phytochemistry and Biological Activities
- Metabolomics and Mass Spectrometry Studies
- Neuroendocrine regulation and behavior
- Acupuncture Treatment Research Studies
- Insect and Arachnid Ecology and Behavior
- Medical Research and Treatments
- Pancreatic function and diabetes
Nagoya University Hospital
2019-2025
University of California, San Diego
2025
University of California, Riverside
2024
Nagoya University
2022
Guangdong Pharmaceutical University
2017-2018
Honey-processed Astragalus is a dosage form of Radix mixed with honey by traditional Chinese medicine processing method which strengthens the tonic effect. polysaccharide (APS), perform its immunomodulatory effects relying on effect Astragalus, therefore, improved pharmacological activity honey-processed (HAPS) might be due to structural changes during processing. The molecular weights HAPS and APS were 1,695,788 Da, 2,047,756 respectively, as determined high performance gel filtration...
Abstract The 22q11.2 deletion syndrome (22q11.2DS) is associated with an increased risk for psychiatric disorders. Although most of the 22q11.2DS patients have a 3.0-Mb deletion, existing mouse models only mimic minor mutation 22q11.2DS, 1.5-Mb deletion. role genes outside in symptoms unclear. In this study, we generated model that reproduced ( Del(3.0 Mb)/ + ) using CRISPR/Cas9 system. Ethological and physiological phenotypes adult male mutants were comprehensively evaluated by...
Abstract Background Rho-kinase is a serine/threonine kinase and regulates actin dynamics. There are two subtypes: 1 2. Recently, we found that Rho-kinase1/2 inhibitor, fasudil, ameliorated schizophrenia-like behaviors in MK-801-treated mice (Takase et al., 2022). However, fasudil has been shown side effects, such as hypotension, which may hinder its clinical application for schizophrenia. Since 2 predominantly expressed brain, hypothesized selective inhibition of might exhibit...
In placebo analgesia, prior experience and expectations lead to pain suppression by the administration of an inert substance, but causal evidence for its neural basis is lacking. To identify underlying circuits, we reverse-translated a conditioned protocol from humans mice. Surprisingly, effect suppresses both nociception unconditioned emotional-motivational pain-related behavior. Descending modulatory neurons in periaqueductal gray (PAG) are critical morphine antinociception. The depends on...
Schizophrenia (SCZ) is a severe psychiatric disorder characterized by positive symptoms, negative and cognitive deficits. Current antipsychotic treatment in SCZ improves symptoms but has major side effects little impact on impairment. The pathoetiology of remains unclear, known to involve small GTPase signaling. Rho kinase, an effector Rho, highly expressed the brain plays role neurite elongation neuronal architecture. This study used touchscreen-based visual discrimination (VD) task...
ABSTRACT Celestial orientation and navigation are performed by many organisms in contexts as diverse migration, nest finding straight-line orientation. The vinegar fly, Drosophila melanogaster, performs menotaxis response to celestial cues during tethered flight can disperse more than 10 km under field conditions. However, we still do not understand how spectral components of pauses impact heading direction flies. To assess individual heading, began testing flies a rotating tether arena...
Abstract Honey‐processed Astragalus , a widely used Qi‐tonifying and immunomodulating herb in traditional Chinese medicine, has strengthened the tonic effects achieved fewer side compared with astragali radix clinical application. Here, we focus on biomarkers pathways of honey‐processed using urine metabolomics that provide basis for building linkage between metabolites rat its symptoms. The spleen Qi deficiency model group, normal group were implemented to evaluate effects. Twelve potential...
Copy-number variations in the ARHGAP10 gene encoding Rho GTPase-activating protein 10 are associated with schizophrenia. Model mice (Arhgap10 S490P/NHEJ mice) that carry "double-hit" mutations Arhgap10 mimic schizophrenia a Japanese patient, exhibiting altered spine density, methamphetamine-induced cognitive dysfunction, and activation of RhoA/Rho-kinase signaling. However, it remains unclear whether signaling due to schizophrenia-associated causes phenotypes these model mice. Here, we...
To identify biomarkers for spleen Qi deficiency by analyzing small molecule metabolites in urine, order to expound the relationship between and metabolic pathways. The model was established through dietary restriction overstrain. All of rats received D-xylose absorption experiment blood routine test. Urine samples were collected next day. urine analyzed using UPLC-Q-TOF-MS obtain dataset group. Principal component analysis (PCA), orthogonal partialleast squares-discriminant (OPLS-DA) other...
Copy number variations in the ARHGAP10 gene encoding Rho GTPase–activating protein 10 are significantly associated with schizophrenia. negatively regulates RhoA/Rho-kinase (ROCK) signaling. We previously demonstrated that fasudil, a non-selective ROCK inhibitor, exhibited antipsychotic-like effects several mouse models of has two subtypes, ROCK1 and ROCK2. is mainly expressed thymus blood, while ROCK2 predominantly brain. Therefore, it expected like selective inhibitors will exhibit effects,...
Schizophrenia (SCZ) is a severe psychiatric disorder characterized by positive symptoms, negative and cognitive deficits. Although its pathoetiology remains unclear, it known to involve small GTPase signaling. Rho kinase, an effector of Rho, highly expressed in the brain plays major role neurite elongation neuronal architecture. This study used touchscreen-based visual discrimination (VD) task investigate effects kinase inhibitors on impairment methamphetamine (METH)–treated mouse model SCZ....
ARHGAP10, a member of Rho GTPase-activating protein (RhoGAP) superfamily which contributes to neuronal development, polarization and function. We developed mouse model schizophrenia with both deletion-type copy-number variation (CNV) single-nucleotide (SNV) in the RhoGAP domain ARHGAP10 gene (ARHGAP10 mutant mice). Methamphetamine (METH) is one kind highly addictive drug induces cognitive deficit human rodents. In this study, we investigated effect METH on performance mice wild-type...
Touchscreen-based cognitive tasks have been developed for rodents to provide a better translational approach across species further understanding of the impairment observed in various neuropsychiatric disorders. Reelin protein (RELN), an extracellular matrix protein, plays important role embryonic neuronal migration and development laminar structure cerebral cortex. In present study, we aimed explore performance RELN-deletion (include exons 52 58) mice, using touchscreen-based visual...
Reelin protein, an extracellular matrix plays important role in embryonic neuronal migration and layer formation cerebral cortex. In the adult brain, reelin is produced by GABA-ergic interneurons affect synaptic plasticity, dendritic morphology cognitive function. We have recently found a schizophrenia patient carrying novel exonic deletion RELN gene CNVanalysis on mainly Japanese population. Meanwhile touchscreen-based operant tasks been developed for rodents to provide better translational...