A5078948280- Cancer Immunotherapy and Biomarkers
- CAR-T cell therapy research
- Immunotherapy and Immune Responses
- Immune Cell Function and Interaction
- Nuclear Structure and Function
- Single-cell and spatial transcriptomics
- Circular RNAs in diseases
- Cardiomyopathy and Myosin Studies
- RNA Research and Splicing
- RNA and protein synthesis mechanisms
- COVID-19 Clinical Research Studies
- MicroRNA in disease regulation
- Ear and Head Tumors
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Genomics and Chromatin Dynamics
- Fuel Cells and Related Materials
- Medical Research and Treatments
- SARS-CoV-2 and COVID-19 Research
- Adipokines, Inflammation, and Metabolic Diseases
- Atherosclerosis and Cardiovascular Diseases
- Cardiac Fibrosis and Remodeling
- Salivary Gland Tumors Diagnosis and Treatment
- Head and Neck Cancer Studies
- COVID-19 Impact on Reproduction
Sichuan University
2022-2024
West China Hospital of Sichuan University
2023-2024
China Medical University
2020-2023
Haikou City People's Hospital
2018
Abstract Although mRNA vaccines are known as potent activators of antigen-specific immune responses against infectious diseases, limited understanding how they drive the functional commitment CD8 + T cells in tumor microenvironment (TME) and secondary lymphoid organs hinders their broader application cancer immunotherapy. Here, we systematically evaluated immunological effects a lipid nanoparticle (LNP)-encapsulated vaccine that encodes human papillomavirus E7 protein (HPV mRNA-LNP),...
The survival prognosis of human papillomavirus (HPV)-positive and HPV-negative head neck squamous cell carcinoma (HNSCC) is largely different, little known about the anti-tumor mechanism tumor-infiltrated exhausted CD8 + T cells (Tex) in HNSCC. We performed cell-level multi-omics sequencing on HNSCC samples to decipher multi-dimensional characteristics Tex cells. A proliferative cluster (P-Tex) which was beneficial outcomes patients with HPV-positive identified. Interestingly, P-Tex...
Abstract Background Dilated cardiomyopathy (DCM) is a serious cardiac heterogeneous pathological disease, which may be caused by mutations in the LMNA gene. Lamins interact with not only lamina-associated domains (LADs) but also euchromatin alone or associates polypeptide 2 alpha (LAP2α). Numerous studies have documented that regulates gene expression interacting LADs heterochromatin. However, role of regulating DCM poorly understood. Here, we determine differential binding genes on induced...
Abstract Tumor‐infiltrating CD4 + T cells orchestrate the adaptive immune response through remarkable plasticity, and expression patterns of exhaustion‐related inhibitory receptors in these differ significantly from those CD8 cells. Thus, a better understanding molecular basis cell exhaustion their responses to checkpoint blockade (ICB) is required. Here, we integrated multiomics approaches define phenotypic profiles exhausted oropharyngeal squamous carcinoma (OPSCC). Two distinct...
Cardiac remodelling is widely accepted as a common characteristic for many heart diseases, especially in failure (HF). Ischaemic cardiomyopathy (ICM) and dilated (DCM) are associated with cardiac remodelling. Both mRNA microRNA potential diagnostic markers therapeutic targets of HF. However, the mechanisms microRNA-mRNA joint regulation HF still unclear. In this study, 3 gene expression profiles from patients without were analysed to harvest shared differentially expressed genes (microRNA...
Numerous studies have shown that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can infect host cells through binding to angiotensin I converting enzyme (ACE2) expressing in various tissues and organs. In this study, we deeply analyzed the single-cell expression profiles of ACE2 fetal adult human hearts explore potential mechanism SARS-CoV-2 harming heart. The molecular docking software was used simulate its variant spike protein with ACE2. genes closely related...
Introduction: In the development of atherosclerosis, remodeling blood vessels is a key process involving plaque formation and rupture. So far, most reports mainly believe that macrophages, smooth muscle cells, endothelial cells located at intima media artery play role in this process. Few studies had focused on whether fibroblasts adventitia are involved regulating disease Methods results: study, we conducted in-depth analysis single-cell RNA-seq data total 18 samples from healthy...
Exhausted CD8
To explore the prognostic effects of previous cancer history on patients with major salivary gland (SGC).
Objective To investigate the clinical value of pulsed pulmonary function in diagnosis chronic obstructive disease(COPD). Methods 32 patients with disease admitted to Haiyang People's Hospital from March 2016 2017 were selected as observation group.Another 32 cases without COPD control group.All received test.The relevant indicators oscillation technology and test compared between two groups. Results The resonance frequency, total respiratory impedance, central airway resistance...
Abstract The survival prognosis of human papillomavirus (HPV)-positive and HPV-negative head neck squamous cell carcinoma (HNSCC) is largely different, little known about the anti-tumor mechanism tumor-infiltrated CD8 + exhausted T cells (Tex) in HNSCC. We performed level multi-omics sequencing on HNSCC samples to decipher multi-dimensional characteristics Tex cells. A proliferative cluster (P-Tex) which was beneficial outcomes patients with HPV-positive identified. Interestingly, P-Tex...