A5068060917- Molecular Junctions and Nanostructures
- Electrochemical Analysis and Applications
- Chromosomal and Genetic Variations
- Genomics and Chromatin Dynamics
- Single-cell and spatial transcriptomics
- Genomics and Phylogenetic Studies
- Advanced Biosensing Techniques and Applications
- Plant Virus Research Studies
- Quantum and electron transport phenomena
- Cell Image Analysis Techniques
- Glioma Diagnosis and Treatment
- Building materials and conservation
- Oral health in cancer treatment
- Neuropeptides and Animal Physiology
- Polymer composites and self-healing
- Advanced battery technologies research
- Radical Photochemical Reactions
- Enhanced Recovery After Surgery
- Immune cells in cancer
- Solid State Laser Technologies
- Supercapacitor Materials and Fabrication
- Microbial infections and disease research
- Plant Molecular Biology Research
- Advanced biosensing and bioanalysis techniques
- Cancer, Stress, Anesthesia, and Immune Response
University of Toronto
2023-2024
Zhejiang Normal University
2022-2024
Zhongnan Hospital of Wuhan University
2021-2023
Wuhan University
2021-2023
Northeast Normal University
2017-2023
Anyang Normal University
2021
Anyang Institute of Technology
2021
UNSW Sydney
2020
Sichuan Agricultural University
2016
The non-random spatial packing of chromosomes in the nucleus plays a critical role orchestrating gene expression and genome function. Here, we present Hi-C analysis chromatin interaction patterns rice (Oryza sativa L.) at hierarchical architectural levels. We confirm that occupy their own territories with certain preferential inter-chromosomal associations. Moderate compartment delimitation extensive TADs (Topologically Associated Domains) were determined to be associated heterogeneous...
Aflatoxin B1 (AFB1) is a potent immunosuppressive agent in endotherms, which can be related to the up-regulated apoptosis of immune organs. In this study, we investigated roles mitochondrial, death receptor, and endoplasmic reticulum pathways induced thymocytes apoptosis. Chickens were fed an aflatoxin containing diet (0.6 mg/kg AFB1) for 3 weeks. Our results showed that (1) AFB1 decrease T-cell subsets, morphological changes, excessive thymus. (2) The involved mitochondrial pathway...
The nature of molecule-electrode interface is critical for the integration atomically precise molecules as functional components into circuits. Herein, we demonstrate that electric field localized metal cations in outer Helmholtz plane can modulate interfacial Au-carboxyl contacts, realizing a reversible single-molecule switch. STM break junction and I-V measurements show electrochemical gating aliphatic aromatic carboxylic acids have conductance ON/OFF behavior electrolyte solution...
Background: Gut microbiota is associated with the progression of brain tumors. However, alterations in gut observed during glioma growth and temozolomide (TMZ) therapy remain poorly understood. Methods: C57BL/6 male mice were implanted GL261 cells. TMZ/sodium carboxymethyl cellulose (SCC) was administered through gavage for five consecutive days (from 8 to 12 after implantation). Fecal samples collected before (T0) on 7 (T1), 14 (T2), 28 (T3) implantation. The analyzed using 16S ribosomal...
Astrocytes are crucially involved in neuroinflammation. Activated astrocytes exhibit at least two phenotypes, A1 (neurotoxic) and A2 (neuroprotective). The phenotype is the major reactive astrocyte aging neurodegenerative diseases. Telmisartan, which an antihypertensive agent, a promising neuroprotective agent. This study aimed to investigate effects of telmisartan on astrocytes. were activated by culturing with conditioned medium derived from lipopolysaccharide-stimulated microglia. induced...
Long-distance insular dispersal is associated with divergence and speciation because of founder effects strong genetic drift. The cotton tribe (Gossypieae) has experienced multiple transoceanic dispersals, generating an aggregate geographic range that encompasses much the tropics subtropics worldwide. Two genera in Gossypieae, Kokia Gossypioides, exhibit a remarkable disjunction, being restricted to Hawaiian Islands Madagascar/East Africa, respectively. We assembled use de novo genome...
Abstract Background Analysis of the relationship between chromosomal structural variation (synteny breaks) and 3D-chromatin architectural changes among closely related species has potential to reveal causes correlates change chromatin remodeling. Of note, contrary extensive studies in animal species, pace pattern following speciation plants remain unexplored; moreover, there is little exploration occurrence synteny breaks context multiple genome topological hierarchies within same model...
The allopolyploid speciation process faces the genomic challenge of stoichiometric disruption caused by merging biparental nuclear genomes with only one (usually maternal) two sets progenitor cytoplasmic genomes. photosynthetic protein 1,5-bisphosphate carboxylase/oxygenase (Rubisco) is composed nuclear-encoded small subunits (SSUs) and plastome-encoded large (LSUs), making it an ideal enzyme to explore evolution cytonuclear accommodation. We investigated variation SSUs their encoding genes...
An effective etching method is developed for the synthesis of hierarchical Ni–Co–Mn hydroxide hollow architectures, which exhibit high performance in electrochemical energy storage.
The electroreductive cleavage of carbon-halogen bonds has attracted increasing attention in both electrosynthesis and pollution remediation. Herein, by employing the situ electrochemical shell-isolated nanoparticle-enhanced Raman spectroscopy (SHINERS) technique, we have successfully investigated dehalogenation process aryl halides with thiol group on a smooth Au electrode aqueous solution at different pH values. obtained potential-dependent spectra directly reveal mixture reduction products...
Probing the adlayer structures on an electrode/electrolyte interface is one of most important tasks in modern electrochemistry for clarifying electrochemical processes. Herein, we have combined cyclic voltammetry and shell-isolated nanoparticle-enhanced Raman spectroscopy techniques to explore potential-dependent Au(111) a room-temperature ionic liquid 1-butyl-3-methylimidazolium hexafluorophosphate (BMIPF6) without or with pyridine (Py). It clearly found that BMI+ cations strongly adsorb...
Mass cytometry (MC) is an emerging and powerful bioanalytical technique for high-dimensional single-cell analysis. While metal-chelating polymers (MCPs) have been the most successful mass tag reagents MC, nanoparticle (NP)-based are of great interest to improve sensitivity MC toward low-abundance biomarkers. Here we present a new structure design potential probes using multifunctionalized mesoporous silica nanoparticles (MSNs), modified with zwitterionic sulfobetaine silanes long-chain...
Mass cytometry is a bioanalytic tool based on atomic mass spectrometry for detecting biomarker expression individual cells. Current reagents employ metal-chelating polymers binding isotopes of hard metal ions. Polymers bearing chelators soft ions offer the promise large increase in multiplexing capabilities, but examples reported so far often have unacceptably high levels nonspecific (NSB). We recently new class with dipicolylamine (DPA) that could bind Re and Pt. They also showed...
Significant variability issues in metal-molecule contacts, such as adsorption geometry, lead to characteristic the electrical responses of individual molecules. Herein, co-assembling 1-ethylimidazole (EIM) on Au(111) has been shown be a feasible and effective strategy for tuning binding configurations pyridine-linked molecular junctions most common aqueous environments atmospheric environments. The single-molecule conductance measurements clearly show transition from multiple peaks single...
The first results of the study on photobleaching and thermally induced recovery in Bi-doped phosphosilicate fiber have been presented. It was revealed that rate bleaching phosphor-related Bi active center (BAC-P) becomes slower with decrease photon energy. quadratic dependence BAC-P laser power is obtained under 532 nm irradiation. effect temperature dynamics also investigated radiation, suggesting a aggravated process upon heating at certain temperatures (≥300∘C). Furthermore, thermal...
Ribulose-1,5-bisphosphate carboxylase/oxygenase (RuBisCo) has long been studied from many perspectives. As a multisubunit (large subunits [LSUs] and small subunits[SSUs]) protein encoded by genes residing in the chloroplast ( rbcL ) nuclear rbcS genomes, RuBisCo also is model for cytonuclear coevolution following allopolyploid speciation plants. Here, we genomic transcriptional coordination of auxiliary chaperonin chaperones that facilitate biogenesis across multiple natural artificially...
Associations between 3D chromatin architectures and epigenetic modifications have been characterized in animals. However, any impact of DNA methylation on architecture plants is understudied, which confined to Arabidopsis thaliana. Because plant species differ genome size, composition, overall packing, it unclear what extent findings from A. thaliana hold other species. Moreover, the incomplete architectural profiles low-resolution high-throughput chromosome conformation capture (Hi-C) data...
Plant long non-coding RNAs (lncRNAs) function in diverse biological processes, and lncRNA expression is under epigenetic regulation, including by cytosine DNA methylation. However, it remains unclear whether 5-methylcytosine (5mC) plays a similar role different sequence contexts (CG, CHG, CHH). In this study, we characterized compared the profiles of genome-wide (including intergenic [lincRNAs] noncoding natural antisense transcripts [lncNATs]) null mutant rice methyltransferase 1, OsMET1-2...
Introduction: Temozolomide (TMZ) induces intestinal mucosa injury that cannot be fully counteracted by supportive treatment.Probiotics regulate gut microbial composition and the host immune system may alleviate this side effect.We aimed to investigate potential mechanism of Lactobacillus rhamnosus GG (LGG) in relieving mucosal induced TMZ.Methods: Glioblastoma mice were divided into four groups: CON (control), LGG (10 9 CFU/mL, treated for 7 days), TMZ (50 mg/ kg•d, 5 LGG+TMZ (LGG days...