A5101902186- Genomics and Phylogenetic Studies
- Genetic diversity and population structure
- Molecular Biology Techniques and Applications
- Circular RNAs in diseases
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Cancer, Hypoxia, and Metabolism
- Bioinformatics and Genomic Networks
- Bacteriophages and microbial interactions
- Reproductive System and Pregnancy
- Nitrogen and Sulfur Effects on Brassica
- Gut microbiota and health
- Plant Molecular Biology Research
- Plant Pathogens and Fungal Diseases
- ATP Synthase and ATPases Research
- Plant tissue culture and regeneration
- Gene expression and cancer classification
- Plant and Fungal Species Descriptions
- Inflammatory mediators and NSAID effects
- Microbial infections and disease research
- Plant Gene Expression Analysis
- Identification and Quantification in Food
- Parasites and Host Interactions
- Gynecological conditions and treatments
- Plant Parasitism and Resistance
Huazhong University of Science and Technology
2018-2025
East China University of Science and Technology
2025
Hubei Academy of Agricultural Sciences
2025
Shanghai Jiao Tong University
2021-2024
Kunming Medical University
2024
Chinese University of Hong Kong
2023
Anhui Agricultural University
2020-2023
Chinese University of Hong Kong, Shenzhen
2023
Third Xiangya Hospital
2022-2023
Central South University
2022-2023
MCScan is an algorithm able to scan multiple genomes or subgenomes in order identify putative homologous chromosomal regions, and align these regions using genes as anchors. The MCScanX toolkit implements adjusted for detection of synteny collinearity that extends the original software by incorporating 14 utility programs visualization results additional downstream analyses. Applications several sequenced plant gene families are shown examples. can be used effectively analyze chromosome...
Tea plant is an important economic crop, which used to produce the world's oldest and most widely consumed tea beverages. Here, we present a high-quality reference genome assembly of (Camellia sinensis var. sinensis) consisting 15 pseudo-chromosomes. LTR retrotransposons (LTR-RTs) account for 70.38% genome, evidence that LTR-RTs play critical roles in size expansion transcriptional diversification genes through preferential insertion promoter regions introns. Genes, particularly those coding...
The effective control of tuberculosis (TB) has been thwarted by the need for prolonged, complex and potentially toxic drug regimens, reliance on an inefficient vaccine absence biomarkers clinical status. promise genomics era TB is substantial, but hindered lack a central repository that collects integrates genomic experimental data about this organism in way can be readily accessed analyzed. Tuberculosis Database (TBDB) integrated database providing access to resources, relevant discovery...
The Stanford Microarray Database (SMD; http://smd.stanford.edu/) is a research tool and archive that allows hundreds of researchers worldwide to store, annotate, analyze share data generated by microarray technology. SMD supports most major platforms, MIAME-supportive can export or import MAGE-ML. primary mission be from the point generation publication dissemination, but it also provides unrestricted access analysis tools public 300 publications. In addition supporting ongoing research,...
SUMMARY Camellia plants include more than 200 species of great diversity and immense economic, ornamental, cultural values. We sequenced the transcriptomes 116 from almost all sections genus . constructed a pan‐transcriptome with 89 394 gene families then resolved phylogeny based on 405 high‐quality low‐copy core genes. Most inferred relationships are well supported by multiple nuclear trees morphological traits. provide strong evidence that shared recent whole genome duplication event,...
Hundreds of researchers across the world use Stanford Microarray Database (SMD; http://smd.stanford.edu/) to store, annotate, view, analyze and share microarray data. In addition providing registered users at access their own data, SMD also provides public tools with which those any user anywhere in world. Previously, new data analysis has been limited by available engineering resources, addition, existing suite did not provide a simple way design, execute pipelines, or document such...
Summary The tea plant ( Camellia sinensis ) is a thermophilic cash crop and contains highly duplicated repeat‐rich genome. It still unclear how DNA methylation regulates the evolution of genes chilling stress in plants. We therefore generated single‐base‐resolution map plants under stress. found that, compared with other plants, genome methylated all three sequence contexts, including CG, CHG CHH (where H = A, T, or C), which further proven to be correlated its repeat content size. show that...
The exploration of antibiotic resistance genes (ARGs) in drinking water reservoirs is an emerging field. Using a curated database, we enhanced the ARG detection and conducted comprehensive analysis using 2.2 Tb deep metagenomic sequencing data to determine distribution ARGs across 16 associated environments. Our findings reveal greater diversity sediments than water, underscoring importance extensive background surveys. Crucial carriers—specifically Acinetobacter, Pseudomonas, Mycobacterium...
Populus not only has significant economic and ecological values, but also serves as a model tree that is widely used in the basic research of growth, physiology, genetics. However, high levels morphological variation extensive interspecific hybridization pose an obstacle for taxonomy, to understanding phylogenetic relationships biogeographical history. In this study, total 103 accessions representing almost all wild species were collected whole-genome re-sequenced examine biogeography On...
Chilling stress threatens the yield and distribution pattern of global crops, including tea plant (Camellia sinensis), one most important cash crops around world. Circular RNA (circRNA) plays roles in regulating growth biotic/abiotic responses. Understanding evolutionary characteristics circRNA its feedbacks to chilling will help elucidate vital circRNAs. In current report, we systematically identified 2702 high-confidence circRNAs under plant, interestingly found that generation was...
Abstract Background Cell pyroptosis has been characterized by cell swelling and pro-inflammatory factors release to aggravate inflammatory reaction., such as interlukin-1 beta (IL-1β) interlukin18 (IL-18). However, the function of famotidine, an antagonist histamine H2-receptor antagonists, in remained unknown. Methods Real-time quantitative PCR (qPCR), western blotting (WB), LDH assay enzyme linked immunosorbent (Elisa) combined with inhibitor were performed analyze effect famotidine on...
KCNQ4 is a common genetic cause of nonsyndromic autosomal dominant hearing loss. We have identified the family in China with (c.701A>G; p.His234Arg) missense variation. In this study, survey and analysis were performed to investigate audiological characteristics Chinese family. The medical history members was collected, underwent pure tone audiometry, acoustic immittance, physical examination. proband additionally examined by ABR (auditory brainstem response) DPOAE (distortion product...
Salt stress severely restricts plant growth and productivity. TCP genes, which are plant-specific transcription factors, play a crucial role in the response. However, their functions pea (Pisum sativum) remain poorly understood. Here, we identified 21 PsTCP genes pea, classified into Class I (PCF) II (CYC/TB1 CIN) through phylogenetic analysis. While physicochemical properties varied significantly within family, gene structures conserved motifs were highly among subfamilies. Comparative...
We have developed a new strategy for differential screening of genes that are expressed in two or more tissues, and used it to identify preferentially both testis ovary. In this approach, testis-specific cDNAs were first generated using the suppression subtractive hybridization technique, cloned arrayed microplates. The inserts from subtracted library amplified by PCR spotted on filters. dot blots screened either testis- ovary-specific cDNA mixtures as probes. By about 2000 putative clones...
// Tengyue Zhang 1, 2, * , Kelong Ma 3, Jin Huang Shitang Wang 4, Yabei Liu 2 Gaofei Fan Miao Guangshan Yang Cheng 4 and Pingsheng 1 School of Clinical Medicine, Shan Dong University, Jinan 250100, China The Cancer Hospital Anhui Province, Provincial Medical Hefei 230032, 3 College Integrated Traditional Chinese Western University Department General Surgery, These authors have contributed equally to this work Correspondence to: Fan, email: wangal2014@sohu.com Wang, blackpippy@163.com...
Within the last decade, extensive research has revealed that curcumin can increase sensitivity of tumor cells to high-energy X-ray radiation in vitro and dual-specificity phosphatase (DUSPs) are implicated cancer, obesity, diabetes, inflammation Alzheimer's disease. To date, article about radiosensitizing effect via enhancement DUSP-2 pathway was rarely reported. Here, we discuss effects on suppressing glioma vivo growth. BALB-c nude mice bearing subcutaneous U87 xenografts were treated with...
BACKGROUND:The aim of this study was to investigate the role ubiquitin carboxyl-terminal hydrolase L1 (UCHL1) in reversal effect verapamil (VER) on chemo-resistance Adriamycin (ADM) treatment hepatocellular carcinoma (HCC). MATERIAL AND METHODS:HCC cell lines SMMC-7721 and BEL-7402 were used as model lines. High-throughput transcriptome sequencing based Illumina technology screen whether UCHL1 mediated VER chemo-resistance. Quantitative real-time PCR (qRT-PCR) performed determine expression...