A5003660971- Vestibular and auditory disorders
- Hearing, Cochlea, Tinnitus, Genetics
- Glaucoma and retinal disorders
- Quantum Chromodynamics and Particle Interactions
- Particle physics theoretical and experimental studies
- Ear Surgery and Otitis Media
- High-Energy Particle Collisions Research
- Ophthalmology and Eye Disorders
- Ear and Head Tumors
- Inflammasome and immune disorders
- Pneumonia and Respiratory Infections
- Atomic and Subatomic Physics Research
- melanin and skin pigmentation
- Advanced Malware Detection Techniques
- Neurological Disorders and Treatments
- Network Security and Intrusion Detection
- Cardiovascular Health and Disease Prevention
- Obstructive Sleep Apnea Research
- Cerebral Venous Sinus Thrombosis
- Cancer Research and Treatments
- Advanced Measurement and Detection Methods
- Security and Verification in Computing
- Ocular Surface and Contact Lens
- Polyamine Metabolism and Applications
- Cancer-related gene regulation
Guangzhou University of Chinese Medicine
2025
Nankai University
2023-2024
Harbin Engineering University
2024
Shandong University
2016-2024
Shandong Provincial Hospital
2016-2024
Shandong First Medical University
2023-2024
Shanxi University
2024
China Three Gorges University
2022
Shandong Institute of Metrology
2022
ABSTRACT Background Mycoplasma pneumoniae (MP) is a major cause of community‐acquired pneumonia (CAP), posing diagnostic challenges. This study evaluates novel inflammatory biomarkers, including neutrophil‐to‐lymphocyte ratio (NLR), monocyte‐to‐lymphocyte (MLR), platelet‐to‐lymphocyte (PLR), systemic immune‐inflammation index (SII) and system inflammation response (SIRI) for MP diagnosis in children. Methods Complete blood count (CBC) results 424 children with infection 150 health were...
Ménière's disease, a multifactorial disorder of the inner ear, is characterized by severe vertigo episodes and hearing loss. Although role immune responses in disease has been proposed, precise mechanisms remain undefined. Here, we show that downregulation serum/glucocorticoid-inducible kinase 1 associated with activation NLRP3 inflammasome vestibular-resident macrophage-like cells from patients. Serum/glucocorticoid-inducible depletion markedly enhances IL-1β production which leads to...
Abstract Meniere’s disease (MD) is a disorder of the inner ear characterized by episodes spontaneous vertigo, fluctuating hearing loss, and tinnitus. Recent studies have demonstrated that IgE may play role in pathogenesis MD. Patients with MD (n = 103), acoustic neuroma 5), healthy subjects 72) were recruited into study. Serum from participants was analyzed for type 2–related cytokines. CD23 expression levels vestibular end organs patients, C57BL/6 mice, or mouse HEI-OC1 cells analyzed....
ABSTRACT The inner ear is a critical sensory organ regulated by the immune system to maintain balance and respond external stimuli. Immune cells like macrophages, lymphocytes, neutrophils, natural killer play important roles in immunity. Inflammatory mediators, such as cytokines chemokines, along with signaling pathways NF‐κB, MAPK, PI3K/AKT, regulate responses ear. Complement activation inflammatory vesicles further affect immune‐related pathology, causing damage epithelium, neurons, blood...
Objectives The study goals were to compare the long‐term efficacy of semicircular canal plugging (SCP) with labyrinthectomy in treatment advanced Meniere's disease (MD). Study Design A retrospective study. Setting Single tertiary medical center. Methods total 116 MD patients (TSCP group 90; 26) complete documents Shandong Provincial ENT Hospital, from March 2017 2019 retrospectively analyzed, including a battery auditory and vestibular function tests, recovery time imbalance level scores...
Abstract Ménière’s disease (MD) is a complex inner ear disorder characterized by range of symptoms, with its pathogenesis linked to immune-related mechanisms. Our previous research demonstrated that IL-1β maturation and release can trigger cell pyroptosis, exacerbating the severity endolymphatic hydrops in mouse model; however, specific mechanism through which influences MD symptoms remains unclear. This study conducted on patients examined changes protein signatures vestibular end organs...
Objective We investigated correlations among clinical features, degree of inner ear endolymphatic hydrops (EH), and hippocampal volume (HV) in different stages Meniere's disease (MD). Methods From February 2021 to April 2022, data were collected from 99 patients (39 males, 60 females, mean age: 50.4 ± 10.0 [range: 26–69] years) with unilateral MD admitted the Department Vertigo Disease Shandong ENT Hospital. The left right ears affected 64 35 patients, respectively. There 50 49 cases early...
Background: TSCP has shown its efficacy in vertigo control for intractable Meniere’s disease. However, hearing impairment remains a problem and hampered the application of surgery.Aims/objectives: To investigate effect dexamethasone on disease patients after to determine whether inflammation is involved this processMaterial methods: who received surgeries were treated with or without postoperatively. All patients’ function evaluated during follow up 2 years surgery compared between two...
There is currently no satisfactory treatment for otolith dysfunctions. Here, we propose a novel surgical method, vestibule plugging (VP), and the results confirm its effectiveness safety in of dysfunction. Laryngoscope, 133:1734–1736, 2023
Objective: To evaluate the feasibility of combining simultaneous triple semicircular canal plugging (TSCP) and cochlear implantation (CI) to treat vertigo hearing loss in advanced Meniere's disease(MD) patients, so as provide an alternative surgical procedure for treating this disorder. Methods: Data from seven who were referred our hospital diagnosed with unilateral MD strictly meeting criteria issued by Chinese Academy Otolaryngology-Head Neck Surgery Committee (2006), Jan. 2015 2016,...
Objective: To investigate the prognostic factors relevant to acute low-tone sensorineural hearing loss (ALHL). Methods: 196 adult ALHL patients, including 82 males and 114 females with mean age of (43.1±14.3)years old were included. All patients received same therapy evaluated curative effect. evaluate impact on prognosis hearing, inclusive age, gender, time delay before first visit, degree deafness, vestibular function, electrocochleogram, serum levels thyroxines by SPSS 18.0 software....
Migraine plays an important role in some subgroups of children with recurrent vertigo. Moreover, the migraine component varies from definite to possibly absent as defined this spectrum three disorders-vestibular childhood (VMC), probable VMC (pVMC), and vertigo (RVC). However, studies on sensory organization balance control these disorders are rare.To explore RVC, VMC, pVMC, when systems challenged.A retrospective analysis was performed 125 (18 female 15 male; aged 11.64 ± 2.74), pVMC (10...
Ménière's disease (MD), a common in the inner ear, is characterized by an increase endolymph cochlear duct and vestibular labyrinth. The pathophysiology of condition appears to be immune response. Studies have shown that basal levels IL-1β increased some MD patients. Here, we used murine model endolymphatic hydrops (EH) study effect anakinra on auditory function. Mice were intraperitoneal injected with or saline before LPS postauricular injection. Weight severity measured, histologic changes...
To retrospectively analyze clinical features in adolescent Menière's disease (MD).
Therapeutic options are limited for patients with intractable Meniere's disease who present recurrent episodes of vertigo and drop attacks.
Machine learning systems are vulnerable to backdoor attacks, where attackers manipulate model behavior through data tampering or architectural modifications. Traditional attacks involve injecting malicious samples with specific triggers into the training data, causing produce targeted incorrect outputs in presence of corresponding triggers. More sophisticated modify model's architecture directly, embedding backdoors that harder detect as they evade traditional data-based detection methods....
Objective: To investigate the effects of SI-4650, a novel small molecule inhibitor spermine oxidase (SMO), on proliferation and epithelial mesenchymal transformation (EMT) human ovarian cancer SKVO-3 cells as well its underlying molecular mechanisms. Methods: treated with 0 μmol/L SI-4650 were used control group, 30, 60 experimental group. The activity SMO, polyamine contents cellular reactive oxygen species (ROS) detected. Cell proliferation, cell cycle mitochondrial membrane potential...
Objective: To investigate the frequency characteristics and pathological of horizontal crista ampullaris in patients with Meniere's disease,and to analyse its structural basis. Methods: Between March, 2019 November, 2019, seventy-two diagnosed as disease (27 males 45 females, aged from 13 74 years, a course ranging 4 months 32 years)in Shandong Provincial ENT Hospital were included.Caloric test, sinusoidal harmonic acceleration test (SHA), video-head impulse (v-HIT), Gadolinium-enhanced...
Objective: To analyze the characteristics of pulse-step-sine (PSS) test in healthy people different ages and to discuss its clinical value. Methods: From July 10, 2018 December 9, 2020, a total 78 volunteers, including 40 males 38 females, were enrolled divided into youth group, middle age group old group. The I Portal NOTC rotational-chair system (NKI) was applied for PSS detection gain, phase, asymmetry, slope step sinusoidal components. Statistical analysis performed using SPSS17.0...