A5101788146- Systemic Lupus Erythematosus Research
- Sulfur Compounds in Biology
- Atherosclerosis and Cardiovascular Diseases
- Antimicrobial Peptides and Activities
- Cytokine Signaling Pathways and Interactions
- Cancer Treatment and Pharmacology
- Cerebrovascular and Carotid Artery Diseases
- Molecular Sensors and Ion Detection
- Pregnancy and preeclampsia studies
- Prenatal Screening and Diagnostics
- Folate and B Vitamins Research
- Genetic and Kidney Cyst Diseases
- Ectopic Pregnancy Diagnosis and Management
- Amino Acid Enzymes and Metabolism
- Neuroscience of respiration and sleep
- Liver Disease Diagnosis and Treatment
- Fetal and Pediatric Neurological Disorders
- Cancer-related molecular mechanisms research
- Ureteral procedures and complications
- Gastric Cancer Management and Outcomes
- Phytochemistry Medicinal Plant Applications
- Restraint-Related Deaths
- Infectious Aortic and Vascular Conditions
- Electronic Health Records Systems
- Chemotherapy-induced cardiotoxicity and mitigation
Qihe People's Hospital
2020-2025
Albert Einstein College of Medicine
2024
Montefiore Medical Center
2024
Shanxi Medical University
2024
Mayo Clinic in Arizona
2024
Affiliated Hospital of Jining Medical University
2017-2024
Shaanxi Provincial People's Hospital
2024
Changchun University of Chinese Medicine
2024
Shandong University of Traditional Chinese Medicine
2024
Southern Medical University
2014-2023
H2S produced in small amounts by mammalian cells has been identified mediating biological signaling functions. However, the situ trapping of endogenous generation is still handicapped a lack straightforward methods with high selectivity and fast response. Here, we encapsulate semi-cyanine-BODIPY hybrid dye (BODInD-Cl) its complementary energy donor (BODIPY1) into hydrophobic interior an amphiphilic copolymer (mPEG-DSPE), especially for building up ratiometric fluorescent nanoprobe...
Ulcerative colitis (UC) is a relapsing disorder characterized by chronic inflammation of the intestinal tract. However, home care UC based on remote monitoring, due to operational complexity and time-consuming procedure, restrain its widespread applications. Here we constructed an optotheranostic nanosystem for self-diagnosis long-acting mitigations at home. The system included two major modules: (i) A disease prescreening module mediated smartphone optical sensing. (ii) Disease real-time...
Depression is a common mental illness. Ferroptosis form of cell death that may be responsible for neurological disease, but the role ferroptosis in depression remains unclear. tRNA-derived small RNA (tsRNA) an emerging non-coding RNA, making it important medium studying diseases. Chronic unpredictable mild stress (CUMS) was used to construct model mice, which treated with ferrostatin-1 (Fer-1). Classical behavioral test, immunofluorescence and sequencing were detect depression-like...
Abstract Mechanoluminescence (ML) is characterized by photon emission under mechanical action, which promising for biomedical applications, such as stress sensing and artificial skin. However, the use of ML in deep tissues has encountered a bottleneck due to need contact excitation. In this paper, magneto‐luminescence microdevice (MLMD) devised realize optical through non‐contact excitation rotating magnetic field. The MLMD composed materials (lanthanide‐doped CaZnOS crystals) magnet bar,...
Background Migraine imposes a substantial global burden, impacting patients and society. Pharmacotherapy, as primary treatment, entails specific adverse reactions. Emphasizing these reactions is pivotal for improving treatment strategies enhancing patients’ well-being. Thus, we conducted comprehensive bibliometric visual analysis of relevant literature. Methodology We search on the Science Citation Index Expanded within Web Science, restricting literature based criteria such document type,...
ABSTRACT Background Penicillin allergy significantly restricts therapeutic options for Helicobacter pylori eradication. This multicenter randomized controlled study was designed to evaluate the efficacy and safety of a novel cefuroxime–tetracycline‐containing bismuth quadruple therapy (Cef‐Tet BQT) as first‐line treatment in this population. Materials Methods Penicillin‐allergic treatment‐naïve patients with confirmed H. infection ( N = 248) were two 14‐day regimens: one received Cef‐Tet BQT...
Introduction Nephrolithiasis is a painful and costly healthcare complication. The most common kidney stones are composed of calcium oxalate thus renal handling an important facet understanding the pathogenesis nephrolithiasis. Recently, Drosophila melanogaster Malpighian tubule (MT) has emerged as robust model trans-epithelial ion transport nephrolithiasis MTs readily form luminal calcium-oxalate crystals in presence oxalate. Prestin (dPrestin, Slc26a6) transports across apical surface MT...
Abstract Intrauterine growth retardation (IUGR) is a serious reproductive problem in humans. The objective of this study was to investigate the effects daily maternal curcumin supplementation during pregnancy on placental function and fetal mouse model IUGR fed low-protein (LP) diet. Pregnant mice were divided into four groups: (1) normal protein (19% protein) diet (NP); (2) LP (8% diet; (3) + 100 mg/kg (LPL); (4) +400 (LPH). results showed that group decreased weight, efficiency, serum...
The purpose of this study is to explore the effects homocysteine (HCY) metabolism and related factors on early spontaneous abortion. We conducted a hospital-based case-control included total 500 cases 1,000 controls in Shaanxi China. Pregnant women waiting for delivery hospital were interviewed report their characteristics other relevant information during pregnancy. unconditional Logisitic regression model was applied assess association between abortion HCY factors. multiplicative...
Abstract The first organocatalytic enantioselective aza‐Michael addition of purine bases to α,β‐unsaturated ketones has been developed, affording Michael adducts in moderate high yields (up 96% yield) and excellent enantioselectivities >99% ee ). A wide range including aliphatic aromatic enones are tolerated this process, generally demonstrating good reactivity, regioselectivity enantioselectivity. showing quite low reactivity the reported catalytic systems, were successfully employed as...
We developed a cysteine specific probe by utilizing the remarkable difference in reactivity toward discriminating from homocysteine and glutathione. This was also successfully used for detection of Cys living cells monitoring cystathionine γ-lyase activity<italic>in vitro</italic>.
Abstract Objectives This study aims to elucidate the transcriptomic signatures and dysregulated pathways in patients with Systemic Lupus Erythematosus (SLE), a particular focus on those persisting during disease remission. Methods We conducted bulk RNA-sequencing of peripheral blood mononuclear cells (PBMCs) from well-defined cohort comprising 26 remission meeting Low Disease Activity State (LLDAS) criteria, 76 experiencing flares, 15 healthy controls. To immune signature changes associated...
Background: The aim of this study was to assess the feasibility, safety and efficacy computed tomography (CT)-guided percutaneous microwave ablation with artificial ascites for problematic hepatocellular tumors.Methods: Forty-eight patients 61 carcinomas who underwent CT-guided were reviewed retrospectively. Lesions less than 5 mm away from gastrointestinal system, diaphragm, pericardium or kidney defined as tumors potential risk thermal damage. Microwave performed after established between...
Analgesic-antitumor peptide (AGAP), one of the scorpion toxin polypeptides, has been shown to have an antitumor activity. Recombinant AGAP (rAGAP) was affect migration and invasion HepG2 cells via a voltage-gated sodium channel (VGSC) β1 subunit. The VGSC subunit validated as cell adhesion molecule (CAM) in human hepatocellular carcinoma (HCC) lines. rAGAP suppresses but no significant effect liver HL7702 without expression. inhibits when is overexpressed cells. To explain these findings,...
Background: Acute kidney injury (AKI) is a common pathological process which occurs in hemorrhage, intoxication, etc. It has been shown that the lymphatic circulation plays an important regulatory role pathogenesis of hemorrhage shock, and exogenous normal lymph (ENL) beneficial effect on multiple organ injuries. In present study, we investigated ENL lipopolysaccharide (LPS)-induced AKI rats. Methods: The was induced by jugular vein injection LPS (iv, 15 mg/kg). After min injection, saline...
Objective The antiphospholipid syndrome (APS) is an important cause of acquired thromboembolic complications and pregnancy morbidity. pathogenic mechanisms that damage the fetal–maternal unit abnormal placental development are incompletely understood in APS patients. Liquid Chromatography/Mass Spectrometry (LC/MS) based metabolomics applied for mechanism disease further supporting research diagnosis management recent years. aim this was to investigate difference serum metabolic profiles...
Ganoderma lucidum spore powder is a traditional Chinese medicine with variety of health benefits. Sporoderm-removed spores (RGLS) can be more effectively absorbed and utilized by the body. Due to extensive clinical application lack long-term (>30 days) safety evaluation RGLS, it necessary evaluate its repeated dose toxicity during longer administration period. Here, we conducted 26-week test RGLS in Sprague‒Dawley (SD) rats. The male female rats were orally administered at doses 0, 0.4, 1.2,...
Background Solitary fibrous tumor (SFT) is a rare soft tissue originating from mesenchymal cells. Thus far, there have been no reported cases of SFT closely related to the iliac vessels. Case presentation An elderly woman was found had lower abdominal mass for more than 20 years. The enhanced computerized tomography (CT) showed progressively hypervascular mass. external blood vessels were mass, which misdiagnosed as an ovarian tumor. During laparotomy, vein seen penetrate tumor, and artery...
Fludarabine is a chemotherapeutic agent with lymphodepleting effects that increasingly used as part of conditioning regimen prior to allogeneic stem cell transplantation. generally considered relatively safe medication only rare cases cardiotoxic side effects.
The organic compound 5-hydroxymethylfurfural (HMF) can be formed from sugars under Maillard reaction and caramelization. In order to study the formation regular of HMF in sugary liquid condiment, vinegar soy sauce were selected. High-performance chromatography (HPLC) was used determine concentrations various brands vinegar. result showed that a range 0.42 115.43 mg/kg for samples 0.43 5.85 samples. concentrates expressed zero-order kinetics model at 100°C before maximum generation all tested...