A5062114502- Amyotrophic Lateral Sclerosis Research
- Acupuncture Treatment Research Studies
- Cellular transport and secretion
- Parkinson's Disease Mechanisms and Treatments
- Calcium signaling and nucleotide metabolism
- Natural product bioactivities and synthesis
- Cancer-related molecular mechanisms research
- Pharmacological Effects of Natural Compounds
- Dermatology and Skin Diseases
- Alzheimer's disease research and treatments
- Vitamin C and Antioxidants Research
- Botulinum Toxin and Related Neurological Disorders
- Biochemical Acid Research Studies
- Neurological Disorders and Treatments
- MicroRNA in disease regulation
- Genetic Neurodegenerative Diseases
- Stroke Rehabilitation and Recovery
- Ginger and Zingiberaceae research
- Neurological Disease Mechanisms and Treatments
- Chemokine receptors and signaling
- Advancements in Semiconductor Devices and Circuit Design
- Natural Compounds in Disease Treatment
- Smart Parking Systems Research
- Curcumin's Biomedical Applications
- Environmental and Social Impact Assessments
National Yang Ming Chiao Tung University
2016-2025
Taipei Tzu Chi Hospital
2022-2024
Dalian Medical University
2023-2024
Buddhist Tzu Chi Medical Foundation
2023-2024
Hefei Normal University
2023
Leibniz-Forschungsinstitut für Molekulare Pharmakologie
2022
Guangdong University of Technology
2021-2022
The University of Tokyo
2022
National Taiwan University
2007-2021
National Tsing Hua University
2021
// Guan-Ting Liu 1 , Hsien-Te Chen 2,3 Hsi-Kai Tsou 4,5 Tzu-Wei Tan 6 Yi-Chin Fong Po-Chen 2 Wei-Hung Yang 3,7,8 Shih-Wei Wang 9 Jui-Chieh 10 and Chih-Hsin Tang 1,6,10,11 Ph.D. Program for Aging, China Medical University, Taichung, Taiwan Department of Orthopedic Surgery, University Hospital, 3 School Chinese Medicine, 4 Functional Neurosurgery Division, Neurological Institute, Taichung Veterans General 5 Early Childhood Care Education, Jen-Teh Junior College Nursing Management, Miaoli...
Gastrointestinal (GI) cancers account for more than one-third of cancer-related mortality, and the prognosis late-stage patients remains poor. Immunotherapy has been proven to extend survival at advanced stages; however, challenges persist in patient selection overcoming drug resistance. Tumor-infiltrating lymphocytes (TILs) tertiary lymphoid structures (TLS) tumor microenvironment (TME) have found be associated with anti-tumor immune responses. 'Hot tumors' high levels infiltration tend...
The cellular endosomal sorting complex required for transport (ESCRT) was recently found to mediate important morphogenesis processes at the nuclear envelope (NE). We previously showed that Epstein-Barr virus (EBV) BFRF1 protein recruits ESCRT-associated Alix modulate NE structure and promote EBV egress. Here, we uncover new factors mechanisms involved in this process. BFRF1-induced vesicles are similar those observed following reactivation. is ubiquitinated, elimination of possible...
Chondrosarcoma is the second most frequently occurring type of bone malignancy that characterized by distant metastasis propensity. Vascular endothelial growth factor-C (VEGF-C) major lymphangiogenic factor, and makes crucial contributions to tumor lymphangiogenesis lymphatic metastasis. Chemokine CCL5 has been reported facilitate angiogenesis in chondrosarcoma. However, effect chemokine on VEGF-C regulation chondrosarcoma largely remained a mystery. In this study, we showed clinical...
To ascertain the genetic and clinical characteristics of GGCCTG hexanucleotide repeat expansion in nucleolar protein 56 gene (NOP56) patients with spinocerebellar ataxia (SCA), sporadic ataxia, or amyotrophic lateral sclerosis (ALS) Taiwan.We conducted molecular studies 109 probands molecularly unassigned SCA from 512 pedigrees, 323 healthy controls, 502 syndromes, 144 ALS. Repeat-primed PCR assays PCR-fragment analysis for number short repeats (<40 units) were performed to NOP56 expansion....
Psoriasis is reported to be a common chronic immune-mediated skin disease characterized by abnormal keratinocytes and cell proliferation. Perilla leaves are rich in essential oils, fatty acids, flavonoids, which recognized for their antioxidant anti-inflammatory effects. In this study, the alleviating effect of oil (PO) extracted from frutescens stems on imiquimod (IMQ) -induced psoriasis-like lesions BALB/c mice were investigated. Results showed that PO ameliorated vivo, reduced expression...
Ultra-low quiescent current (<inline-formula> <tex-math notation="LaTeX">$I_{Q}$ </tex-math></inline-formula>) low-dropout regulator is the only solution for compact size Internet of Things (IoT) electronic devices. This paper presents an ultra-low <inline-formula> </tex-math></inline-formula> low dropout regulator, including error amplifier (EA) compensated by adaptive control (ACC), leakage feedback network, comparator, analog transient enhancement (ATE), and digital (DTE). The chip was...
Bipolar disorder (BD) is highly heritable with recurrent manic and depressive episodes. The present study focused on episode in BD patients, to investigate state-specific transcriptome alterations between acute remission, including mRNAs, long non-coding RNAs (lncRNAs), miRNAs using microarray RNA sequencing platforms. patients were enrolled clinical biological samples collected at both remission status following-up for least two-months. Symptom severity was assessed by Young Mania Rating...
Background and Objectives . Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease characterized by loss of motor neurons in the brainstem, cortex, spinal cord. Oxidative stress neuroinflammation have been implicated pathophysiology ALS. Members family damage-associated molecular patterns, including reactive oxygen species, high-mobility group box 1, eosinophil-derived neurotoxin (EDN), may participate pathological conditions. In this study, we aim to discover new...
Article22 March 2022Open Access Source DataTransparent process Endosomal phosphatidylinositol 3-phosphate controls synaptic vesicle cycling and neurotransmission Guan-Ting Liu Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP), Berlin, Germany Contribution: Investigation, Methodology Search for more papers by this author Gaga Kochlamazashvili Data curation, Formal analysis, Dmytro Puchkov orcid.org/0000-0001-8341-4847 Conceptualization, Rainer Müller orcid.org/0000-0003-3464-494X...
Intestinal ischemia-reperfusion (II/R) injury is a common pathological process with high morbidity and mortality. Effective prevention treatment therapies for II/R are clinically necessary. 6-Shogaol (6-SG), the main active ingredient in dried ginger, behaviors multiple biological activities, including anti-inflammation, antioxidation, anti-apoptosis. This study aims to elucidate protective effects mechanism of 6-SG against II/R-induced injury.
Abstract Sepsis causes systemic inflammatory responses and acute lung injury (ALI). Despite modern treatments, sepsis‐related ALI mortality remains high. Aqueous extract of Descuraniae Semen (AEDS) exerts anti‐endoplasmic reticulum (ER) stress, antioxidant anti‐inflammatory effects. AEDS alleviates inflammation oedema in ALI. Sodium‐potassium‐chloride co‐transporter isoform 1 (NKCC1) is essential for regulating alveolar fluid important The NKCC1 activity regulated by upstream with‐no‐lysine...
Stroke leads to tremendous impacts on patients and the healthcare system. It is crucial explore potential management of rehabilitation. Acupuncture traditional Chinese herbal medicine (TCHM) integrated with conventional rehabilitation benefit post-stroke functional recovery. We retrospectively reviewed medical records all included in Integrated Traditional Chinese-Western Medicine care program for stroke (ITCWM-stroke program) 2019 Taipei Tzu Chi Hospital investigate effects acupuncture TCHM...
Fish exhibit different muscle structures and growth characteristics compared with mammals. We used a spatial transcriptomics approach examined myotomal sections from zebrafish. Adult muscles were divided into eight regions according to gene expression characteristics. Slow was located in the wedge-shaped region near lateral line at base of dorsal fin, intermediate ribbon-shaped adjacent slow muscle, fast deep trunk, surrounded by muscle; interior further 6 parts their transcriptomic...
Although a vesicular nucleocytoplasmic transport system is believed to exist in eukaryotic cells, the features of this pathway are mostly unknown. Here, we report that BFRF1 protein Epstein-Barr virus improves nuclear envelope (NE) facilitate translocation and clearance components. expression induces vesicles selectively components cytoplasm. With use aggregation-prone proteins as tools, found aggregated dispersed when these BFRF1-induced formed. BFRF1-containing engulf NE-associated...
Lycium barbarum have received an increasing popularity due to its powerful biological activity and medicinal use. However, the effect of on skin remains largely uncharacterized. The general purpose this paper was characterize phenolic compounds in extract (LBE) using LC-HRMS/QTOF method investigate whether topical administration LBE can repair barrier dysfunction mice. Our data demonstrated that could not only decrease ROS level matrix metalloproteinase expression, but also strengthen...
Background Lipopolysaccharide (LPS)-induced acute lung injury (ALI) induces endoplasmic reticulum stress, unfolded protein response (UPR), apoptosis, and inflammation. Inositol-requiring enzyme 1 (IRE1)-α is important for adaptive apoptotic UPR determination during ER stress. The aqueous extract of Descuraniae Semen (AEDS) reported to be a safe effective herb the treatment pulmonary edema as it shows anti-inflammatory activities. Methods We investigated effects AEDS on LPS-induced ALI in...
LG72 can increase mitochondrial ROSs and oxidative stress has been implicated in the pathophysiology of amyotrophic lateral sclerosis (ALS). The serum level or LG72-related molecules might therefore be associated with ALS. Here, we aim to determine autoantibody against potential as a biomarker for diagnosis ALS.Seventy-eighty patients ALS, 45 AD, 43 PD 88 healthy adults were enrolled.The concentration was more than fourfold lower ALS other control groups (p < 0.001). AUC 0.9627 when cut-off...
IntroductionVascular cognitive impairment (VCI) is the second most frequent form of disorder. It mainly caused by a diseased cerebral vasculature and affects patients' activities daily living (ADL). Previous studies have demonstrated that acupuncture therapy promising complementary treatment significantly improves status ADL in VCI patients. This study aimed to investigate effects different types therapies on patients provide evidence-based clinical recommendations.MethodsWe searched five...