A5033521771- Genetics and Plant Breeding
- Plant Disease Resistance and Genetics
- Asthma and respiratory diseases
- MicroRNA in disease regulation
- Plant Stress Responses and Tolerance
- Genetic Mapping and Diversity in Plants and Animals
- Wheat and Barley Genetics and Pathology
- Plant Pathogens and Fungal Diseases
- IL-33, ST2, and ILC Pathways
- Pancreatitis Pathology and Treatment
- Crop Yield and Soil Fertility
- Plant Pathogens and Resistance
- Rice Cultivation and Yield Improvement
- Neonatal Respiratory Health Research
- Agriculture, Plant Science, Crop Management
- Plant Molecular Biology Research
- Plant Disease Management Techniques
- Photosynthetic Processes and Mechanisms
- Cancer-related molecular mechanisms research
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Plant Gene Expression Analysis
- Mycotoxins in Agriculture and Food
- Agricultural Science and Fertilization
- Seed and Plant Biochemistry
- Food and Agricultural Sciences
Brigham and Women's Hospital
2022-2025
Harvard University
2022-2025
Indian Veterinary Research Institute
2022-2024
Harvard University Press
2024
Indian Agricultural Research Institute
1990-2023
Shiv Nadar University
2018-2021
Government of Uttar Pradesh
2019
Dr. Yashwant Singh Parmar University of Horticulture and Forestry
1987
NAC proteins are plant-specific transcription factors (TFs). Although they play a pivotal role in regulating distinct biological processes, TFs maize yet to be investigated comprehensively. Within the genome, we identified 152 putative domain-encoding genes (ZmNACs), including eight membrane-bound members, by systematic sequence analysis and physically mapped them onto ten chromosomes of maize. In silico ZmNACs comparison with similar other plants such as Arabidopsis, rice, soybean, revealed...
Earlier studies were focused on the genetics of temperate and tropical maize under drought. We identified genetic loci their association with functional mechanisms in 240 accessions subtropical using a high-density marker set water stress.Out 61 significant SNPs (11 false-discovery-rate-corrected associations), across agronomic traits, models, locations by subjecting to stress at flowering stage, 48% associated drought-tolerant genes. Maize gene models revealed that mapped for traits fact...
Waterlogging causes extensive damage to maize crops in tropical and subtropical regions. The identification of tolerance genes their interactions at the molecular level will be helpful engineer tolerant genotypes. A whole-genome transcriptome assay revealed specific role response waterlogging stress susceptible Genes involved synthesis ethylene auxin, cell wall metabolism, activation G-proteins formation aerenchyma adventitious roots, were upregulated genotype. Many transcription factors,...
A robust phenotypic plasticity to ward off adverse environmental conditions determines performance and productivity in crop plants. Flax (linseed), is an important cash produced for natural textile fiber (linen) or oilseed with many health promoting products. This prone drought stress yield losses parts of the world. Despite recent advances research a number crops, related progress flax very limited. Since, response this plant has not been addressed at molecular level; we conducted...
Abstract In India the area of land given to maize ranks fifth after rice, wheat, sorghum and pearl millet. grain production holds fourth position over Of 61 diseases recorded so far, 15 one nematode problem, are considered constitute major constraints limiting production. The are: four foliar diseases, two pre‐flowering three post‐flowering stalk rots, downy mildews sheath diseases. Information on ear, cob kernel smut virus is presented. An account post‐harvest microbial problems given. Four...
A genomewide transcriptome assay of two subtropical genotypes maize was used to observe the expression genes at seedling stage drought stress. The number expressed differentially greater in HKI1532 (a tolerant genotype) than PC3 sensitive genotype), indicating primary differences transcriptional level stress tolerance. global coexpression networks differed significantly with respect modules and pattern within modules. total 174 drought-responsive were selected from HKI1532, their network...
Globally, one-third of the population is affected by iron (Fe) and zinc (Zn) deficiency, which severe in developing underdeveloped countries where cereal-based diets predominate. The genetic biofortification approach most sustainable one cost-effective ways to address Fe Zn malnutrition. Maize a major source nutrition sub-Saharan Africa, South Asia Latin America. Understanding systems’ biology identification genes involved homeostasis facilitate development Fe- Zn-enriched maize. We...
Abstract Introduction Uncontrolled or severe asthma results in symptomatic usage of short‐acting ß2‐agonist (SABA) usage. MicroRNAs (miRNAs) are posttranslational regulators that can influence biology. This study aims to identify miRNAs associated with increased SABA Methods Small RNA sequenced from blood serum 1,132 children aged 6 14 years the Genetics Asthma Costa Rica Study was used for this analysis. Logistic regression identified patients who required These miRNA were validated...
MicroRNAs (miRNAs) are crucial post-transcriptional regulators involved in inflammatory diseases, such as asthma. Poor lung function and airflow issues childhood linked to the development of chronic obstructive pulmonary disease (COPD) adulthood. We analyzed small RNA-Seq data from 365 peripheral whole blood samples Genetics Asthma Costa Rica Study (GACRS) for association with levels measured by FEV1/FVC. Differentially expressed (DE) miRNAs were identified using DESeq2 R, adjusting...
Rationale: Pediatric asthma is heterogeneous, with varied clinical presentations and treatment responses. Metabolomic profiling may uncover shared unique biological mechanisms across traits that characterize pediatric asthma. Objectives: To the presentation of by examining metabolome's relationship 22 traits, categorized into 5 phenotypic domains: airway hyperresponsiveness (AHR), atopy, lung function (LF), blood eosinophil (B-EOS), neutrophil (B-NEU). Methods: was conducted on plasma...
Intrauterine smoke (IUS) exposure during early childhood has been associated with a number of negative health consequences, including reduced lung function and asthma susceptibility. The biological mechanisms underlying these associations have not established. MicroRNAs regulate the expression numerous genes involved in development. Thus, investigation impact IUS on miRNA human development may elucidate post-natal respiratory outcomes. We sought to investigate effect hypothesized that...
Climate changes and environmental stresses have a consequential association with crop plant growth yield, meaning it is necessary to cultivate crops that tolerance toward the changing climate disturbances such as water stress, temperature fluctuation, salt toxicity. Recent studies shown trans-acting regulatory elements, including microRNAs (miRNAs) transcription factors (TFs), are emerging promising tools for engineering naive improved varieties multiple enhanced quality well yield. However,...
Maize is an increasingly important food crop in southeast Asia. The elucidation of its genetic architecture, accomplished by exploring quantitative trait loci and useful alleles various lines across numerous breeding programs, therefore great interest. present study aimed to characterize subtropical maize using high-quality SNPs distributed throughout the genome. We genotyped a panel 240 elite inbred carried out linkage disequilibrium, diversity, population structure, principal component...
Bronchodilator response (BDR) is a measure of improvement in airway smooth muscle tone, inhibition liquid accumulation and mucus section into the lumen to short-acting beta-2 agonists that varies among asthmatic patients. MicroRNAs (miRNAs) are well-known post-translational regulators. Identifying miRNAs associated with BDR could lead better understanding underlying complex pathophysiology. The purpose this study identify circulating bronchodilator asthma decipher possible mechanism...
The mechanisms underlying severe allergic asthma are complex and unknown, meaning it is a challenge to provide the most appropriate treatment. This study aimed identify novel biomarkers for stratifying asthmatic patients according severity, uncover biological that lead development of uncontrolled phenotype. By using miRNA PCR panels, we analyzed expression 752 miRNAs in serum samples from control subjects (
MicroRNAs (miRNAs) have been linked to allergic diseases but their effects on sensitisation allergens in individuals with asthma are unknown. We aimed identify miRNAs associated house dust mite (HDM) childhood asthma.