A5049917918- MicroRNA in disease regulation
- Asthma and respiratory diseases
- Computational Drug Discovery Methods
- IL-33, ST2, and ILC Pathways
- Neonatal Respiratory Health Research
- Circular RNAs in diseases
- Cancer-related molecular mechanisms research
- Systemic Lupus Erythematosus Research
- Biomarkers in Disease Mechanisms
- Diverse Scientific Research Studies
- Monoclonal and Polyclonal Antibodies Research
- RNA and protein synthesis mechanisms
- Retinal Diseases and Treatments
- Metabolomics and Mass Spectrometry Studies
- Pediatric health and respiratory diseases
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Bioinformatics and Genomic Networks
- Inhalation and Respiratory Drug Delivery
- Glycosylation and Glycoproteins Research
- Environmental Toxicology and Ecotoxicology
- Psychosomatic Disorders and Their Treatments
- Medicinal Plants and Neuroprotection
- Allergic Rhinitis and Sensitization
- Adipose Tissue and Metabolism
- Vector-borne infectious diseases
Brigham and Women's Hospital
2020-2025
Harvard University
2019-2025
Vanderbilt University
2023-2025
Indian Institute of Toxicology Research
2010-2024
Academy of Scientific and Innovative Research
2024
King George's Medical University
2010-2024
Massachusetts General Hospital
2023
Shanghai Jiao Tong University
2020-2022
Ithaca College
2022
Woman's Hospital
2021
Obesity, a growing threat to the modern society, represents an imbalance of metabolic queues that normally signal arcuate hypothalamic nucleus, critical brain region sensing and regulating energy homeostasis. This is achieved by various neurons many which developmentally originate from proopiomelanocortin (POMC)-expressing lineage. Within mature originating this lineage, we aimed identify non-coding genes in control function adulthood. In work, used microRNA mimic delivery POMCCre-dependent...
MicroRNAs (miRNAs) are crucial post-transcriptional regulators involved in inflammatory diseases, such as asthma. Poor lung function and airflow issues childhood linked to the development of chronic obstructive pulmonary disease (COPD) adulthood. We analyzed small RNA-Seq data from 365 peripheral whole blood samples Genetics Asthma Costa Rica Study (GACRS) for association with levels measured by FEV1/FVC. Differentially expressed (DE) miRNAs were identified using DESeq2 R, adjusting...
Drug development is a long and costly process, repurposing existing drugs for use toward different disease or condition may serve as cost-effective alternative. As drug targets with genetic support have doubled success rate, genetics-informed holds promise in translating findings into therapeutics. In this study, we developed Genetics Informed Network-based Repurposing via silico Perturbation (GIN-DRIP) framework applied the to repurpose type-2 diabetes (T2D). GIN-DRIP T2D, it integrates...
Abstract The present study examines the role of advanced glycation end products (AGEs) as biomolecular biomarkers for proliferative diabetic retinopathy (PDR). A cross-sectional with a total 80 consecutive cases type 2 diabetes mellitus (DM) was divided into no (NoDR) ( n = 20), non-proliferative (NPDR) PDR and controls 20). AGEs were assessed by assay N-carboxymethyl-lysine (Nε-CML). Nε- CML evaluated using receiver operating characteristic curve (ROC) analysis, area under (AUC) determined....
Many microRNAs (miRNAs) have been associated with asthma and chronic obstructive pulmonary disease (COPD). Longitudinal lung function growth trajectories of children asthma-normal growth, reduced (RG), early decline (ED), RG an ED (RGED)-have observed, RGED adverse outcomes, including COPD.Our aim was to determine whether circulating miRNAs from age in would be prognostic patterns over the next 16 years.We performed small RNA sequencing on sera 492 aged 5 12 years mild-to-moderate CAMP...
Background: Inorganic biomaterials are biologically active and used as implants drug delivery system. They have therapeutically elements present in their framework that released the physiological milieu. Release of these dopants above supraphysiological limit may produce adverse effects physicochemical interactions with loaded drugs. Therefore, this necessitates evaluating vivo release kinetics, biodistribution, excretion profiles from barium-doped bioglass (BaBG) has potential...
Bronchodilator response (BDR) is a measure of improvement in airway smooth muscle tone, inhibition liquid accumulation and mucus section into the lumen to short-acting beta-2 agonists that varies among asthmatic patients. MicroRNAs (miRNAs) are well-known post-translational regulators. Identifying miRNAs associated with BDR could lead better understanding underlying complex pathophysiology. The purpose this study identify circulating bronchodilator asthma decipher possible mechanism...
MicroRNAs (miRs) are small non-coding RNA molecules of around 18-22 nucleotides that key regulators many biologic processes, particularly inflammation. The purpose this study was to determine the association circulating miRs from asthmatic children with seasonal variation in allergic inflammation and asthma symptoms.We used available sequencing on blood serum 398 mild-to-moderate Childhood Asthma Management Program. We symptom data at baseline allergen affection status skin prick tests as...
MicroRNAs have been independently associated with asthma and COPD; however, it is unclear if microRNA associations will overlap when evaluating retrospective acute exacerbations. Objective: We hypothesized that peripheral blood microRNAs would be exacerbations in a pediatric cohort such may also relevant to COPD Methods: conducted small-RNA sequencing on 374 whole-blood samples from children ages 6-14 years who participated the Genetics of Asthma Costa Rica Study (GACRS) 450 current former...
Vitamin D may help to alleviate asthma exacerbation because of its anti-inflammation effect, but the evidence is inconsistent in childhood asthma. MiRNAs are important mediators pathogenesis and also excellent non-invasive biomarkers. We hypothesized that circulating miRNAs associated with modified by vitamin levels. sequenced baseline serum from 461 participants Childhood Asthma Management Program (CAMP). Logistic regression was used associate miRNA expression through interaction analysis...
MicroRNAs (miRNAs) have been linked to allergic diseases but their effects on sensitisation allergens in individuals with asthma are unknown. We aimed identify miRNAs associated house dust mite (HDM) childhood asthma.
Of children with recurrent wheezing in early childhood, approximately half go on to develop asthma. MicroRNAs have been described as excellent non-invasive biomarkers due their prognostic utility. We hypothesized that circulating microRNAs can predict incident asthma and prediction might be modified by vitamin D. selected 75 participants at 3 years old from the Vitamin D Antenatal Asthma Reduction Trial (VDAART). Plasma samples were collected age sequenced for small RNA-Seq. The read counts...
Retinal S-antigen and interphotoreceptor retinoid-binding protein-3 play a significant role in the etiopathogenesis of Eales' disease. Protein 3D structures are functionally very important progression disease, hence these better target for further drug designing relative studies. We developed model structure retinol-binding retinal protein human involved Functional site prediction is related step; hence, current course analysis, we predicted putative functional residues proteins. Molecular...
The optimization of machining parameters is critical to the quality machined products and production rate.This paper aims optimize surface roughness aluminium-2014 alloy by adjusting computer numerical control (CNC) turning, including, cutting speed, depth cut feed rate.According L9 orthogonal array, a total nine experiments were conducted according Taguchi method with different parameter settings.The was measured tester, evaluated signal-to-noise ratio (SNR).The analysis variance (ANOVA)...
Eales' disease is an idiopathic retinal vasculitis of the eye. The predominantly characterized by recurrent vitreous hemorrhage. Interphotoreceptor retinol-binding protein 3 plays a significant role in etiopathogenesis this condition. It transports retinoids between pigment epithelium and photoreceptors; hence, potential target for docking studies. In silico data reveal that herbal molecules interact with regulatory domains interphotoreceptor (IRBP-3), resulting into score also forms H-bond...
Asthma patient response to inhaled corticosteroids (ICS) is variable and difficult quantify. We aimed define a measure of steroid suitable for pharmacogenetic research in longitudinal cross-sectional cohorts. Using data from the Childhood Management Program (CAMP) asthma cohort, we defined Cross-sectional STEroid Response (CASTER) data. then applied this slices four independent cohorts: The Improving Control Trial (IMPACT), Salmeterol or Corticosteroids Study (SOCS), Pediatric Controller...
Diabetic retinopathy (DR) is the most common diabetic eye disease and a leading cause of blindness. The role angiopoietin-2 tyrosine kinase receptor well-reported in angiogenesis during onset disease. purpose this study to screen out more potential herbal molecules which can evidently be used as better, natural safe drug against