A5100687832- Synthesis and biological activity
- Cancer therapeutics and mechanisms
- Quinazolinone synthesis and applications
- Cancer Immunotherapy and Biomarkers
- Click Chemistry and Applications
- Renal Transplantation Outcomes and Treatments
- Synthesis and Characterization of Heterocyclic Compounds
- CAR-T cell therapy research
- Organ Transplantation Techniques and Outcomes
- Renal and Vascular Pathologies
- Nanocluster Synthesis and Applications
- Metal complexes synthesis and properties
- Mesenchymal stem cell research
- Histone Deacetylase Inhibitors Research
- Radiomics and Machine Learning in Medical Imaging
- Molecular Sensors and Ion Detection
- Hematopoietic Stem Cell Transplantation
- Protein Degradation and Inhibitors
- Organic Light-Emitting Diodes Research
- X-ray Diffraction in Crystallography
- Thyroid and Parathyroid Surgery
- Synthesis and Biological Evaluation
- Cell death mechanisms and regulation
- Alzheimer's disease research and treatments
- Crystallization and Solubility Studies
Huaqiao University
2016-2025
People’s Hospital of Linqing
2016-2025
Xian Yang Central Hospital
2025
Renji Hospital
2022
Shanghai Jiao Tong University
2022
Second Affiliated Hospital of Guangzhou Medical University
2019-2021
Guangzhou Medical University
2019-2021
Yuhuangding Hospital
2019-2020
Qingdao University
2013-2020
Quanzhou Normal University
2019-2020
Herein, we firstly reported a series of biphenyl compounds bearing hydroxamic acid moiety as PD-L1/class I HDACs dual inhibitors. Among them, compound 14 displayed the strongest inhibitory activity in vitro against HDAC2 and HDAC3 with IC50 values 27.98 nM 14.47 nM, had an value 88.10 for PD-1/PD-L1 interaction. Importantly, could upregulate expression PD-L1 CXCL10 low-expression cancer cell line (MCF-7), highlighting potential to enhance efficacy by recruiting T-cell infiltration into TME...
A dual-emissive tris-heteroleptic ruthenium complex is designed, synthesized and applied for the ratiometric photoluminescent detection of amyloid-β (Aβ) aggregation in both steady transient states. The Aβ supported by transmission electron microscopy confocal laser scanning analysis. In addition, molecular docking calculations have been performed to gain insights into interaction mode between fibrils.
Small-molecule inhibitors targeting programmed cell death-1/programmed death-ligand 1 (PD-1/PD-L1) interactions can compensate for the shortcomings of antibody-based and have attracted considerable attention, some which already entered clinical trials. Herein, based on our previous study small-molecule PD-L1 inhibitors, we reported a series 8-(o-tolyl)quinazoline derivatives by skeleton merging strategy. Homogenous time-resolved fluorescence (HTRF) assay against PD-1/PD-L1 interaction...
A novel series of benzothiazole derivatives bearing the ortho ‐hydroxy‐ N ‐acylhydrazone moiety were designed, synthesized, and evaluated for their procaspase‐3 kinase activation activities antiproliferative against five cancer cell lines (NCI‐H226, SK‐N‐SH, HT29, MKN‐45, MDA‐MB‐231). Most target compounds showed moderate to excellent cytotoxic activity all tested lines. The most promising compound 18e (procaspase‐3 EC 50 = 0.31 µM) with IC values ranging from 0.24 0.92µM was 4.24–12.2 times...
Human mesenchymal stromal cells (MSCs) harbor immunomodulatory properties to induce the generation of suppressive T cells. MSCs have been successfully used in treating graft-versus-host disease (GVHD) accompanied by abundant inflammatory cytokines such as IL-27. This study investigated effects IL-27 on human placenta-derived (hPMSCs) CD4+IL-10+IFN-γ+ vitro and humanized xenogenic GVHD NOD/SCID model. The results showed that percentages were significantly increased activated PBMC from both...
Objective: This study aimed to investigate the application of nanocarbon in surgical endoscopy patients with thyroid cancer for clinical tracing level VI sentinel lymph nodes (SLNs) and parathyroid gland protection. Materials Methods: Ninety-three papillary carcinoma (PTC) who underwent an endoscopic operation were included. We randomly divided these into a control group (n = 42) 51). For group, after exposure, was injected gland, SLNs resected subjected frozen sectioning routine...
Three tris-heteroleptic mononuclear Ru(II) complexes with dual fluorescence and phosphorescence-[Ru(dpma)(bpy)(phen)]2+ (12+), [Ru(dpma)(bpy)(dppz)]2+ (22+), [Ru(dpma)(phen)(dppz)]2+ (32+)-have been designed used as ratiometric light-response probes for DNA, where dpma is di(pyrid-2-yl)(methyl)-amine, bpy 2,2'-bipyridine, phen 1,10-phenanthroline, dppz dipyridophenazine, respectively. Single crystals of complex 2(PF6)2 have obtained studied by X-ray analysis. The interactions these different...
Abstract We observed an unusual case of Lipofibroadenoma (LFA) in the anterior mediastinum with a 21-year-old man, who was detected mass on chest X-ray scan for one month. Thymothymectomy then performed and excised completely, which tumor histologically composed epithelial cells, lymphocytes, mature adipose fibrous tissue. Within tumor, fat cells distributed singly or multifocally under ground fibro tissue hyaline degeneration, were arranged as crack structure lymphocytes infiltrated...
A series of benzothiazole derivatives bearing a pyridine-semicarbazone moiety were identified as apoptosis inducers <italic>via</italic> activation procaspase-3 to caspase-3.
Eight nonplanar terdentate cyclometalated Pt(II) complexes (Pt1–Pt8) have been designed and synthesized with the general formula [Pt(N∧C∧N)Cl], where N∧C∧N represents 1,3-bis(N-methyl-N′-(pyridin-2-yl)amino)benzene (H-L) derivatives various substituents (−CH3, −OCH3, −Cl, −CF3). These were fully characterized via a wide array of spectroscopic X-ray single-crystal diffraction techniques. The electrochemical, photophysical electroluminescence properties these compounds investigated. As...
Compound 13 was identified as a VEGFR-2/HDAC dual inhibitor by integrating the pharmacophores of fruquintinib and HDAC inhibitor.
Two unprecedented hexacyclic dimeric diterpenoids from <italic>Jatropha curcas</italic> and <bold>2</bold> showed significant NO inhibitory activity with IC<sub>50</sub> values of 5.65 μM.