A5101751627- Medical Imaging and Analysis
- Orthopedic Surgery and Rehabilitation
- Spine and Intervertebral Disc Pathology
- Gastrointestinal motility and disorders
- Genomics and Chromatin Dynamics
- Diet and metabolism studies
- Mitochondrial Function and Pathology
- Biomarkers in Disease Mechanisms
- Gut microbiota and health
- Innovation and Knowledge Management
- Advanced X-ray and CT Imaging
- Bone and Dental Protein Studies
- Body Composition Measurement Techniques
- Advanced Glycation End Products research
- High Altitude and Hypoxia
- Cell death mechanisms and regulation
- Bone and Joint Diseases
- Sphingolipid Metabolism and Signaling
- Foot and Ankle Surgery
- Osteoarthritis Treatment and Mechanisms
- Radiomics and Machine Learning in Medical Imaging
- Knee injuries and reconstruction techniques
- Shoulder and Clavicle Injuries
- COVID-19 diagnosis using AI
- Epigenetics and DNA Methylation
Tianjin University
2020-2025
Tianjin Hospital
2008-2025
First Affiliated Hospital of Xi'an Jiaotong University
2023
Third Xiangya Hospital
2019-2022
Central South University
2014-2022
Tianjin University of Traditional Chinese Medicine
2021-2022
Zhejiang University
2004-2021
First Hospital of Jilin University
2021
Jilin University
2021
Third Affiliated Hospital of Guangzhou Medical University
2019
Alkaliptosis, a type of regulated cell death driven by intracellular alkalization, was first described in pancreatic ductal adenocarcinoma (PDAC) cells after treatment with the opioid analgesic drug JTC801. Here, we used mass-spectrometry-based target identification, cellular thermal shift assay, and point mutation technologies to reveal ATP6V0D1 as direct JTC801 that drives alkaliptosis human PDAC cells. Functionally, protein stability ATP6V0D1, when mediated JTC801, increases interaction...
Study Design. Retrospective single-institution study. Objective. To develop and validate an automated convolutional neural network (CNN) to measure the Cobb angle, T1 tilt coronal balance, clavicular height of shoulders, T5–T12 sagittal balance for accurate scoliosis diagnosis. Summary Background Data. Scoliosis, characterized by a angle >10°, requires reliable measurements guide treatment. Traditional manual are time-consuming have low inter- intra-observer reliability. While some tools...
The transcription factor ZBP-89 has been implicated in the induction of growth arrest and apoptosis. In this article, we demonstrate that was able to restrain senescence NCI-H460 human lung cancer cells, through epigenetically regulating p(16INK4a) expression. Specifically, our results indicate knockdown by RNA interference stimulated cellular as judged senescence-associated beta-galactosidase activity assay heterochromatin foci assay, process could be reversed interference-mediated...
Inflammasome activation can trigger an inflammatory and innate immune response through the release of cytokines induction pyroptosis. A dysfunctional inflammasome has been implicated in development human pathologies, including sepsis septic shock. Here, we show that advanced glycosylation end-product specific receptor (AGER/RAGE) is required for caspase-11 macrophages. nuclear damage-associated molecular pattern (nDAMP) complex, high-mobility group box 1, histone, DNA, promote...
Destructions in the intestinal ecosystem are implicated with changes slow transit constipation (STC), which is a kind of intractable characterized by colonic motility disorder. In order to deepen understanding structure STC gut microbiota and relationship between fecal metabolites, we first used 16S rRNA amplicon sequencing evaluate 30 patients healthy subjects. The α-diversity group was changed certain degree, β-diversity significantly different, indicated that composition inconsistent...
Abstract Background Type 2 diabetes mellitus (T2DM) induced diabetes-associated cognitive dysfunction (DACD) that seriously affects the self-management of T2DM patients, is currently one most severe T2DM-associated complications, but mechanistic basis remains unclear. Mitochondria are highly dynamic organelles, whose function refers to a broad spectrum features such as mitochondrial dynamics, mitophagy and so on. Mitochondrial abnormalities have emerged key determinants for function,...
To investigate the correlation of miR-125a/b expression with acute exacerbations chronic obstructive pulmonary disease (AECOPD) patients and inflammatory cytokines. Eighty-seven AECOPD patients, 93 stable (COPD) 100 health volunteers (HCs) were recruited. Plasma samples collected from at day 1, 7, 14, 28 admission COPD as well HCs. Total RNA was extracted plasma, relative expressions determined by quantitative real time-polymerase chain reaction. MiR-125b had a great capacity for...
To investigate the expression of high-mobility group box 1 (HMGB1) in human dental pulp tissues and effects HMGB1 on proliferation odontoblastic differentiation cells (hDPCs).Immunohistochemical assay, immunofluorescence staining flow cytometric analysis were used to detect hDPCs, respectively. The hDPCs was examined by CCK-8 after culturing primary presence with different doses. Odontoblastic determined using alkaline phosphatase (ALPase) activity assay mineralized nodule formation....
To investigate the value of expression annexin A2, microvessel density (MVD) and CD105 in pancreatic ductal adenocarcinoma (PDAC) tissues adjacent normal tissues, immunohistochemical staining was used. The positive rate Annexin A2 MVD higher than that (p<0.005). Expression correlated with histological grade (p<0.05). cancers TNM stage IIb stageI~IIa (p<0.026). Cancerous 3+ had lower other Patients high worse prognosis. However, our study did not confirm an independent risk factor for...
Abstract Background Lumbago is a global disease that affects more than 500 million people worldwide. Bone marrow oedema one of the main causes condition and clinical diagnosis mainly made by radiologists manually reviewing MRI images to determine whether present. However, number patients with has risen dramatically in recent years, which brought huge workload radiologists. In order improve efficiency diagnosis, this paper devoted developing evaluating neural network for detecting bone edema...
Modic changes (MCs) are the most prevalent classification system for describing intravertebral MRI signal intensity changes. However, interpreting these intricate images is a complex and time-consuming process. This study investigates performance of single shot multibox detector (SSD) ResNet18 network-based automatic detection MCs. Additionally, it compares inter-observer agreement observer-classifier in MCs diagnosis to validate feasibility deep learning network-assisted classified
Application value of rib surface positioning ruler combined with volumetric CT measurement in selection the incision for minimally invasive internal fixation fracture was investigated. A total 80 patients who received fractures Tianjin Hospital Affiliated to University (Tianjin, China) from May 2018 April 2019 were selected. Patients treated method (n=42) or traditional (n=38). The following parameters compared between two groups: Preset accuracy, operation length, time, intraoperative...
To develop a comprehensive differential expression profile for osteoporosis based on two independent data sources.Using hindlimb unloading (HLU) rat model to mimic syndrome in humans (animal experiments), the significant differentially expressed mRNAs were analyzed using RNA-seq. The enriched GO terms as well KEGG signaling pathways also deeply investigated. Using clinical specimens verify functions of potential hub genes (biomarkers) (clinical 128 suspected cases from January 2019 December...
ABSTRACT Objective Modic changes (MCs) classification system is the most widely used method in magnetic resonance imaging (MRI) for characterizing subchondral vertebral marrow changes. However, it shows a high degree of sensitivity to variations MRI because its semiquantitative nature. In 2021, authors this further proposed quantitative and reliable MC grading method. automated tools grade MCs are lacking. This study developed investigated performance convolutional neural network (CNN)...
Objective To siscuss the clinical significance of early diagnosis knee varus and osteoarthritis with combination negative position non‐negative radiography. Methods One hundred eighty patients whose femorotibial angles <182° (genu positive) measured by X‐ray at weight‐bearing ≥182° negative) non‐weight‐bearing were selected as sample group from those who received joint Magnetic resonance imaging (MRI) examination July 2015 to 2017. both control group. Femorotibial groups respectively...
The early diagnosis and treatment of spinal fractures paraplegia by CT scan is investigated in depth its clinical value discussed this paper. In paper, a novel circulatory generation adversarial network, Spine-GAN, proposed for the various diseases. algorithmic model can fully automate segmentation classification multiple structures, such as intervertebral discs, vertebrae, neuroforamina, simultaneously to intelligently generate complete diagnosis. innovation method that Spine-GAN not only...
To investigate the accuracy of X-ray and magnetic resonance imaging (MRI) measurements in evaluating displacement humeral lateral condyle fracture (HLCF) different positions forearm based on human cadaveric HLCF models.Three elbow models were successfully established. The wrist joint was fixed, rotated forward along mid-axis. maximum distance between two segments gap defined as LFS (lateral space) distance, at anterior posterior margins model PFS (posterior space). distances measured during...