A5101466777- Sperm and Testicular Function
- Spinal Fractures and Fixation Techniques
- Diabetes Management and Research
- Male Reproductive Health Studies
- Urinary Bladder and Prostate Research
- Atrial Fibrillation Management and Outcomes
- Spine and Intervertebral Disc Pathology
- Pelvic and Acetabular Injuries
- Genital Health and Disease
- Urological Disorders and Treatments
- Urologic and reproductive health conditions
- Acute Ischemic Stroke Management
- Diet, Metabolism, and Disease
- CNS Lymphoma Diagnosis and Treatment
- Cardiac electrophysiology and arrhythmias
- Urinary and Genital Oncology Studies
- Evaluation Methods in Various Fields
- Liver Disease Diagnosis and Treatment
- Korean Urban and Social Studies
- Intensive Care Unit Cognitive Disorders
- Testicular diseases and treatments
- Mycotoxins in Agriculture and Food
- CAR-T cell therapy research
- Antiplatelet Therapy and Cardiovascular Diseases
- Selenium in Biological Systems
Xiangya Hospital Central South University
2024
Central South University
2024
Nanjing Medical University
2023-2024
Bureau of Agriculture of Guangzhou Municipality
2023
South China University of Technology
2023
Guangzhou University
2023
Shenzhen University
2022
Hunan Cancer Hospital
2022
Tianjin University
2020
Tianjin Hospital
2020
Abstract Ciprofol (HSK3486) is a newly developed, highly selective γ‐aminobutyric acid‐A (GABA A ) receptor potentiator that recently approved for new indication of sedation patients in the intensive care unit (ICU) China. This analysis aimed to characterize population pharmacokinetics (PopPKs) ciprofol and evaluate relationship exposure with hypotension mechanically ventilated ICU. total 462 subjects 3918 concentration measurements from two clinical trials ICU, four elective surgical...
Anrikefon (HSK21542), a potent and selective peripheral kappa opioid receptor (KOR) agonist developed by Haisco, effectively blocks pain itch signals. To develop population pharmacokinetic (PK) model for anrikefon conduct exposure-response (E-R) analysis safety efficacy in postoperative patients. The Population PK uses NONMEM software with data from six trials. E-R relationships were assessed using three Covariate screening Bayesian post-hoc simulations identified relevant factors compared...
Different from canonical drugs, CAR T-cells are "living drugs", which derived patient's own blood. Studies of the pharmacokinetics could improve our understanding their efficacy, safety, optimal dosage, and other characterizes. We previously reported a phase I study novel fully human BCMA-targeting (CT103A) in 18 patients with relapsed/refractory multiple myeloma. CT103A exhibited extraordinary persistence low anti-drug antibody positivity. To figure out pharmacokinetic characterizes...
Abstract Background Nowadays, there is a lack of effective intraoperative treatment for thoracolumbar fascia injury (TFI) osteoporotic vertebral compression fractures (OVCFs), which may lead to postoperative residual pain. We aimed evaluate the clinical effects cocktail injection on TFI during percutaneous vertebroplasty (PVP) OVCFs. Methods A retrospective study OVCFs with underwent PVP (Cocktail group, 58 cases) or (Routine 64 was conducted. The surgical outcomes, visual analog scale (VAS)...
ZSP1601 is a novel pan-phosphodiesterase inhibitor developed in China specifically for the treatment of nonalcoholic fatty liver disease (NAFLD).
Introduction Leritrelvir (RAY1216) acts as a main protease inhibitor that hinders the cleavage of viral precursor proteins, thereby inhibiting virus replication SARS-CoV-2). This antiviral mechanism has shown significant efficacy against novel coronavirus. Preclinical studies have demonstrated potent activity and favorable safety profile this compound. study aims to develop pharmacokinetic model for leritrelvir, with without ritonavir enhancer evaluate necessity co-administration investigate...
Abstract: The goal of this study was to explore minimally invasive transurethral imaging and surgery for the treatment severe, persistent hematospermia in cases that were refractory conservative treatments. included 43 patients (aged 22–77 years; average, 44.6 years) with long‐lasting, severe hematospermia, accompanied by discomfort or pain lumbosacral perineal region, dysuria, frequent micturition, decreased semen volume, and/or azoospermia. Patient symptoms had persisted 1 10 years...
To date, limited research has been conducted on the functionality of glymphatic system during recovery phase severe traumatic brain injury (sTBI). This study aimed to use a diffusion tensor image analysis along perivascular space (DTI-ALPS) evaluate function in patients recovering from sTBI who underwent unilateral decompressive craniectomy, and examine correlation between ALPS index size cranial defect. We hypothesized that assessments would reveal ongoing impairments among phase.
Application value of rib surface positioning ruler combined with volumetric CT measurement in selection the incision for minimally invasive internal fixation fracture was investigated. A total 80 patients who received fractures Tianjin Hospital Affiliated to University (Tianjin, China) from May 2018 April 2019 were selected. Patients treated method (n=42) or traditional (n=38). The following parameters compared between two groups: Preset accuracy, operation length, time, intraoperative...
Background: The rivaroxaban dose regimen for patients with nonvalvular atrial fibrillation (NVAF) is complex in Asia. Given the high interindividual variability and risk of bleeding caused by Asians, influencing factors relationship between outlier biomarkers events need exploration. Methods: integrated pharmacokinetics (PK)/pharmacodynamics (PD) models were characterized based on rich PK/PD data from 304 healthy volunteers sparse PD [anti-factor Xa activity (anti-Xa) prothrombin (PT)] 223...
Abstract Purpose To evaluate the effects of percutaneous vertebroplasty (PVP) with conventional transpedicle approach (CTA) or basal transverse process-pedicle (BTPA) on treatment thoracolumbar osteoporotic vertebral compression fractures (TL-OVCFs) narrow pedicles. Methods A retrospective study TL-OVCFs pedicles was performed, including 78 cases CTA and 84 BTPA. The surgical outcomes, radiographic parameters [the width height pedicle (PW, PH), inclination angle puncture (PIA)] clinical...
Dorzagliatin is a first-in-class small molecule glucokinase activator (GKA) that improves pancreatic insulin secretion behavior and regulates hepatic glucose conversion in concentration-dependent manner. The primary objective of this study was to develop population pharmacokinetic model dorzagliatin evaluate the influence covariates, such as demographic characteristics liver kidney function, on pharmacokinetics provide basis for medication guidance. data came from six clinical trials. Based...
Background: Some studies have investigated the diagnostic accuracy of cytokeratin-19 fragments (CYFRA 21-1) for bladder cancer, but no study has compared serum and urine CYFRA 21-1 in a head-to-head manner. The aims this were to (I) compare (II) investigate whether can be improved if used together.
Abstract We report the discovery of PSR J1909+0122 by Five-hundred-meter Aperture Spherical Radio Telescope (FAST) as part Commensal Astronomy FAST Survey. has a spin period 1.257 s and dispersion measure 186.2 pc cm −3 . The averaged pulse profile shows two distinct components. performed single-pulse study based on one-hour observation at 1.25 GHz 2021 August 23. used threshold 5 σ ep to nulling fraction (NF) 63% ± 1.5%. longitude-resolved fluctuation spectra fast Fourier transform binary...
Penile reconstruction following cancer resection has long been a challenge due to demand for both aesthetic and functional preservation. Although various methods have attempted achieve goals, none succeeded entirely. In this report, we introduce novel reconstructive technique on 64-year-old patient with squamous cell carcinoma of the glans penis. The consisted two staged procedures. First, dermal substitute, consisting bovine collagen, was sutured onto defect after partial glansectomy three...
In the present study, our clinical experience of high ligation internal spermatic vein in single-port transumbilical laparoscopy was reviewed and summarized. Eleven patients with varicocele on left side received department. All operations succeeded mean operation time 26 min. None suffered from complications hospital days were 4 days. The under is a new approach that can be applied young patients. High has advantages clear visual field, simple procedure, rapid recovery, minimal invasion low...