A5112909179- Reproductive Biology and Fertility
- Sperm and Testicular Function
- interferon and immune responses
- Systemic Lupus Erythematosus Research
- Renal and related cancers
- RNA regulation and disease
- Genetic and Kidney Cyst Diseases
- Ginkgo biloba and Cashew Applications
- Animal Genetics and Reproduction
- Neuroinflammation and Neurodegeneration Mechanisms
- Endoplasmic Reticulum Stress and Disease
- Viral Infections and Immunology Research
- Phagocytosis and Immune Regulation
- Retinal Diseases and Treatments
- Ion Transport and Channel Regulation
- Sphingolipid Metabolism and Signaling
- Calcium signaling and nucleotide metabolism
- Immune Response and Inflammation
- Inflammasome and immune disorders
- Intracerebral and Subarachnoid Hemorrhage Research
- Cytokine Signaling Pathways and Interactions
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Neurological Disease Mechanisms and Treatments
University of Pittsburgh
2019-2025
Magee-Womens Research Institute
2023
Wenzhou Hospital of Traditional Chinese Medicine
2021
Nanjing Medical University
2013
Harbin Medical University
2008
Ultraviolet (UV) radiation and reactive oxygen species (ROS) impair the physiological functions of retinal pigment epithelium (RPE) cells by inducing cell apoptosis, which is main cause age-related macular degeneration (AMD). The mechanism UV/ROS induces RPE death not fully addressed. Here, we observed activation a ceramide-endoplasmic reticulum (ER) stress-AMP activated protein kinase (AMPK) signaling axis in UV hydrogen peroxide (H2O2)-treated cells. H2O2 induced an early ceramide...
Abstract Normal embryo development is a complex process that requires normal sperm to fertilize oocytes. Abnormal embryogenesis can be caused by either abnormal oocytes or sperm. However, the impact of sperm‐associated factors often underappreciated. Association between defects in chromatin and poor has been consistently reported. In cells, most histones are replaced protamines remodel cell chromatin. mechanism nuclear protein replacement largely unknown. Meiosis expressed gene 1 (MEIG1)...
Inflammasome activation can trigger an inflammatory and innate immune response through the release of cytokines induction pyroptosis. A dysfunctional inflammasome has been implicated in development human pathologies, including sepsis septic shock. Here, we show that advanced glycosylation end-product specific receptor (AGER/RAGE) is required for caspase-11 macrophages. nuclear damage-associated molecular pattern (nDAMP) complex, high-mobility group box 1, histone, DNA, promote...
The manchette is a transient and unique structure present in elongating spermatids required for proper differentiation of the germ cells during spermatogenesis. Previous work indicated that MEIG1/PACRG complex locates involved transport cargos, such as SPAG16L, to build sperm flagellum. Here, using co-immunoprecipitation pull-down approaches various cell systems, we established DNALI1, an axonemal component originally cloned from Chlamydomonas reinhardtii , recruits stabilizes PACRG confirm...
Ginkgolide B (GB) is widely used in the treatment of neurological diseases and exerts anti‑inflammatory neuroprotective effects. Microglia serve an important role central nervous inflammation. The present study investigated effect GB on inflammation <em>in vivo</em> vitro</em>. BV2 cells were activated with lipopolysaccharide (LPS) to establish a cellular model neuroinflammation. Cell viability was determined using Counting Kit‑8 assay secreted levels TNF‑α, IL‑1 IL‑6 measured ELISAs. nitric...
Abstract Background Aicardi-Goutières syndrome (AGS) is a severe infant or juvenile-onset autoimmune disease characterized by inflammatory encephalopathy with an elevated Type 1 interferon-stimulated gene (ISG) expression signature in the brain. Mutations seven different protein-coding genes, all linked to DNA/RNA metabolism sensing, have been identified AGS patients, but none of them has demonstrated activate IFN pathway brain animal. The molecular mechanism not well defined. Adenosine...
Abstract Background:Aicardi-Goutières syndrome (AGS) is a severe autoimmune disease characterized by inflammatory encephalopathy with an elevated Type 1 interferon-stimulated gene (ISG) expression signature in the brain. It featured early-onset and progressive loss of intellectual abilities motor control. Gene mutations 7 protein-coding genes were found to be associated AGS. However, causative role these neuropathogenesis has not been demonstrated animal models, mechanism neurodegeneration...
Abstract Objective: To determine whether and how a gene mutation found in Aicardi-Goutières syndrome (AGS), severe autoimmune encephalopathy, is sufficient to activate the interferon signaling pathway brain. Background: Genetic mutations six coding genes were associated with AGS patients, however, none of them was demonstrated able cause IFN activation brain tissue, most critical pathogenetic change AGS. How an AGS-associated activates that leads injury remains be revealed. Methods: A...